-
1
-
-
84920837701
-
Cancer statistics, 2015
-
1 Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2015. CA Cancer J Clin 65 (2015), 5–29.
-
(2015)
CA Cancer J Clin
, vol.65
, pp. 5-29
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
2
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
2 Scagliotti, G.V., Parikh, P., von Pawel, J., et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26 (2008), 3543–3551.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
von Pawel, J.3
-
3
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
3 The Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511 (2014), 543–550.
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
4
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
4 The Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489 (2012), 519–525.
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
5
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
5 Rosell, R., Carcereny, E., Gervais, R., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13 (2012), 239–246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
6
-
-
84921892043
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials
-
6 Yang, J.C., Wu, Y.L., Schuler, M., et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol 16 (2015), 141–151.
-
(2015)
Lancet Oncol
, vol.16
, pp. 141-151
-
-
Yang, J.C.1
Wu, Y.L.2
Schuler, M.3
-
7
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
7 Mok, T.S., Wu, Y.L., Thongprasert, S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361 (2009), 947–957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
8
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
8 Solomon, B.J., Mok, T., Kim, D.W., et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371 (2014), 2167–2177.
-
(2014)
N Engl J Med
, vol.371
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
9
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
9 Soda, M., Choi, Y.L., Enomoto, M., et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448 (2007), 561–566.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
10
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
10 Choi, Y.L., Takeuchi, K., Soda, M., et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 68 (2008), 4971–4976.
-
(2008)
Cancer Res
, vol.68
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
-
11
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
11 Koivunen, J.P., Mermel, C., Zejnullahu, K., et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 14 (2008), 4275–4283.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
12
-
-
84869462031
-
Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology
-
12 Ou, S.H., Bartlett, C.H., Mino-Kenudson, M., Cui, J., Iafrate, A.J., Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist 17 (2012), 1351–1375.
-
(2012)
Oncologist
, vol.17
, pp. 1351-1375
-
-
Ou, S.H.1
Bartlett, C.H.2
Mino-Kenudson, M.3
Cui, J.4
Iafrate, A.J.5
-
13
-
-
63949086127
-
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
-
13 Takeuchi, K., Choi, Y.L., Togashi, Y., et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res 15 (2009), 3143–3149.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3143-3149
-
-
Takeuchi, K.1
Choi, Y.L.2
Togashi, Y.3
-
14
-
-
84941013285
-
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer
-
14 Hrustanovic, G., Olivas, V., Pazarentzos, E., et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med 21 (2015), 1038–1047.
-
(2015)
Nat Med
, vol.21
, pp. 1038-1047
-
-
Hrustanovic, G.1
Olivas, V.2
Pazarentzos, E.3
-
15
-
-
84959421317
-
K-RAS mutations indicating primary resistance to crizotinib in ALK-rearranged adenocarcinomas of the lung: report of two cases and review of the literature
-
15 Mengoli, M.C., Barbieri, F., Bertolini, F., Tiseo, M., Rossi, G., K-RAS mutations indicating primary resistance to crizotinib in ALK-rearranged adenocarcinomas of the lung: report of two cases and review of the literature. Lung Cancer 93 (2016), 55–58.
-
(2016)
Lung Cancer
, vol.93
, pp. 55-58
-
-
Mengoli, M.C.1
Barbieri, F.2
Bertolini, F.3
Tiseo, M.4
Rossi, G.5
-
16
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
16 Shaw, A.T., Yeap, B.Y., Mino-Kenudson, M., et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27 (2009), 4247–4253.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
17
-
-
69349083935
-
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
-
17 Rodig, S.J., Mino-Kenudson, M., Dacic, S., et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 15 (2009), 5216–5223.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5216-5223
-
-
Rodig, S.J.1
Mino-Kenudson, M.2
Dacic, S.3
-
18
-
-
78349237453
-
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment
-
18 Camidge, D.R., Kono, S.A., Flacco, A., et al. Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res 16 (2010), 5581–5590.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5581-5590
-
-
Camidge, D.R.1
Kono, S.A.2
Flacco, A.3
-
19
-
-
84871986190
-
Immunohistochemistry is a reliable screening tool for identification of ALK rearrangement in non-small-cell lung carcinoma and is antibody dependent
-
19 Conklin, C.M., Craddock, K.J., Have, C., Laskin, J., Couture, C., Ionescu, D.N., Immunohistochemistry is a reliable screening tool for identification of ALK rearrangement in non-small-cell lung carcinoma and is antibody dependent. J Thorac Oncol 8 (2013), 45–51.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 45-51
-
-
Conklin, C.M.1
Craddock, K.J.2
Have, C.3
Laskin, J.4
Couture, C.5
Ionescu, D.N.6
-
20
-
-
85029252296
-
Diagnosis of EML4-ALK translocation with FISH, immunohistochemistry, and real-time polymerase chain reaction in patients with non-small cell lung cancer: the Latin American experience
-
20 Cruz-Rico, G., Morales-Oyarvide, V., Aviles-Salas, A., et al. Diagnosis of EML4-ALK translocation with FISH, immunohistochemistry, and real-time polymerase chain reaction in patients with non-small cell lung cancer: the Latin American experience. Ann Oncol 25:suppl (2014), iv426–iv470.
-
(2014)
Ann Oncol
, vol.25
, pp. iv426-iv470
-
-
Cruz-Rico, G.1
Morales-Oyarvide, V.2
Aviles-Salas, A.3
-
21
-
-
84960099751
-
Prospective and clinical validation of ALK immunohistochemistry: results from the phase I/II study of alectinib for ALK-positive lung cancer (AF-001JP study)
-
21 Takeuchi, K., Togashi, Y., Kamihara, Y., et al. Prospective and clinical validation of ALK immunohistochemistry: results from the phase I/II study of alectinib for ALK-positive lung cancer (AF-001JP study). Ann Oncol 27 (2016), 185–192.
-
(2016)
Ann Oncol
, vol.27
, pp. 185-192
-
-
Takeuchi, K.1
Togashi, Y.2
Kamihara, Y.3
-
22
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
22 Takeuchi, K., Choi, Y.L., Soda, M., et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res 14 (2008), 6618–6624.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
-
23
-
-
84925411861
-
Fluorescence in situ hybridization, immunohistochemistry, and next-generation sequencing for detection of EML4-ALK rearrangement in lung cancer
-
23 Pekar-Zlotin, M., Hirsch, F.R., Soussan-Gutman, L., et al. Fluorescence in situ hybridization, immunohistochemistry, and next-generation sequencing for detection of EML4-ALK rearrangement in lung cancer. Oncologist 20 (2015), 316–322.
-
(2015)
Oncologist
, vol.20
, pp. 316-322
-
-
Pekar-Zlotin, M.1
Hirsch, F.R.2
Soussan-Gutman, L.3
-
24
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
24 Christensen, J.G., Zou, H.Y., Arango, M.E., et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 6 (2007), 3314–3322.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
-
25
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
-
25 Camidge, D.R., Bang, Y.J., Kwak, E.L., et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 13 (2012), 1011–1019.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
26
-
-
84865431278
-
Updated results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
abstract 7533
-
26 Kim, D., Ahn, M., Shi, Y., et al. Updated results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol, 30(suppl), 2012 abstract 7533.
-
(2012)
J Clin Oncol
, vol.30
-
-
Kim, D.1
Ahn, M.2
Shi, Y.3
-
27
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
27 Shaw, A.T., Kim, D.W., Nakagawa, K., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368 (2013), 2385–2394.
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
28
-
-
84906936412
-
Ceritinib in advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC): results of the ASCEND-1 trial
-
abstract 8003
-
28 Kim, D., Mehra, R., Tan, D., et al. Ceritinib in advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC): results of the ASCEND-1 trial. J Clin Oncol, 32(suppl), 2014, 5s abstract 8003.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Kim, D.1
Mehra, R.2
Tan, D.3
-
29
-
-
84941674243
-
ASCEND-2: a single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ)
-
abstract 8059
-
29 Mok, T., Dpigel, D., Felip, E., et al. ASCEND-2: a single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ). J Clin Oncol, 33(suppl), 2015 abstract 8059.
-
(2015)
J Clin Oncol
, vol.33
-
-
Mok, T.1
Dpigel, D.2
Felip, E.3
-
30
-
-
84941630750
-
ASCEND-3: a single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naïve adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC)
-
abstract 8060
-
30 Felip, E., Orlov, S., Park, K., et al. ASCEND-3: a single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naïve adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC). J Clin Oncol, 33(suppl), 2015 abstract 8060.
-
(2015)
J Clin Oncol
, vol.33
-
-
Felip, E.1
Orlov, S.2
Park, K.3
-
31
-
-
84941674245
-
A phase I/II study with a CNS-penetrant, selective ALK inhibitor alectinib in ALK-rearranged non-small cell lung cancer (ALK+ NSCLC) patients (pts): updates on progression free survival (PFS) and safety results from AF-001JP
-
abstract 8061
-
31 Ohe, Y., Nishio, M., Kiura, K., et al. A phase I/II study with a CNS-penetrant, selective ALK inhibitor alectinib in ALK-rearranged non-small cell lung cancer (ALK+ NSCLC) patients (pts): updates on progression free survival (PFS) and safety results from AF-001JP. J Clin Oncol, 33(suppl), 2015 abstract 8061.
-
(2015)
J Clin Oncol
, vol.33
-
-
Ohe, Y.1
Nishio, M.2
Kiura, K.3
-
32
-
-
84964343904
-
Alectinib in crizotinib-refractory ALK-rearranged non-small-cell lung cancer: a phase II global study
-
32 Ou, S.I., Ahn, J.S., De Petris, L., et al. Alectinib in crizotinib-refractory ALK-rearranged non-small-cell lung cancer: a phase II global study. J Clin Oncol 34 (2016), 661–668.
-
(2016)
J Clin Oncol
, vol.34
, pp. 661-668
-
-
Ou, S.I.1
Ahn, J.S.2
De Petris, L.3
-
33
-
-
84959324643
-
Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial
-
33 Shaw, A.T., Gandhi, L., Gadgeel, S., et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol 17 (2016), 234–242.
-
(2016)
Lancet Oncol
, vol.17
, pp. 234-242
-
-
Shaw, A.T.1
Gandhi, L.2
Gadgeel, S.3
-
34
-
-
84941618755
-
Safety and efficacy of brigatinib (AP26113) in advanced malignancies, including ALK+ non–small cell lung cancer (NSCLC)
-
abstract 8062
-
34 Camidge, R., Bazhenova, L., Salgia, R., et al. Safety and efficacy of brigatinib (AP26113) in advanced malignancies, including ALK+ non–small cell lung cancer (NSCLC). J Clin Oncol, 33(suppl), 2015 abstract 8062.
-
(2015)
J Clin Oncol
, vol.33
-
-
Camidge, R.1
Bazhenova, L.2
Salgia, R.3
-
35
-
-
84951827380
-
Clinical activity and safety of PF-06463922 from a dose escalation study in patients with advanced ALK+ or ROS1+ NSCLC
-
abstract 8018
-
35 Shaw, A., Bauer, T., Felip, E., et al. Clinical activity and safety of PF-06463922 from a dose escalation study in patients with advanced ALK+ or ROS1+ NSCLC. J Clin Oncol, 33(suppl), 2015 abstract 8018.
-
(2015)
J Clin Oncol
, vol.33
-
-
Shaw, A.1
Bauer, T.2
Felip, E.3
-
36
-
-
84888637339
-
Pharmacokinetics and safety of an oral ALK inhibitor, ASP3026, observed in a phase I dose escalation trial
-
abstract 2602
-
36 Patnaik, A., LoRussa, P., Ball, H., et al. Pharmacokinetics and safety of an oral ALK inhibitor, ASP3026, observed in a phase I dose escalation trial. J Clin Oncol, 31(suppl), 2013 abstract 2602.
-
(2013)
J Clin Oncol
, vol.31
-
-
Patnaik, A.1
LoRussa, P.2
Ball, H.3
-
37
-
-
84905160569
-
A phase I trial of X-396, a novel ALK inhibitor, in patients with advanced solid tumors
-
abstract 8030
-
37 Horn, L., Infante, J., Blumenschein, G., et al. A phase I trial of X-396, a novel ALK inhibitor, in patients with advanced solid tumors. J Clin Oncol, 32(suppl), 2014, 5s abstract 8030.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Horn, L.1
Infante, J.2
Blumenschein, G.3
-
38
-
-
84919714767
-
Phase (Ph) 1/2 study of TSR-011, a potent inhibitor of ALK and TRK, including crizotinib-resistant ALK mutations
-
abstract e19005
-
38 Weiss, G., Sachdev, J., Infante, J., et al. Phase (Ph) 1/2 study of TSR-011, a potent inhibitor of ALK and TRK, including crizotinib-resistant ALK mutations. J Clin Oncol, 32(suppl), 2014 abstract e19005.
-
(2014)
J Clin Oncol
, vol.32
-
-
Weiss, G.1
Sachdev, J.2
Infante, J.3
-
39
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
39 Choi, Y.L., Soda, M., Yamashita, Y., et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 363 (2010), 1734–1739.
-
(2010)
N Engl J Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
40
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
40 Katayama, R., Shaw, A.T., Khan, T.M., et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med, 4, 2012, 120ra117.
-
(2012)
Sci Transl Med
, vol.4
, pp. 120ra117
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
41
-
-
84917678260
-
Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
-
41 Katayama, R., Friboulet, L., Koike, S., et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res 20 (2014), 5686–5696.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5686-5696
-
-
Katayama, R.1
Friboulet, L.2
Koike, S.3
-
42
-
-
80052793410
-
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
-
42 Sasaki, T., Koivunen, J., Ogino, A., et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res 71 (2011), 6051–6060.
-
(2011)
Cancer Res
, vol.71
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
-
43
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
43 Doebele, R.C., Pilling, A.B., Aisner, D.L., et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 18 (2012), 1472–1482.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
44
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
44 Katayama, R., Khan, T.M., Benes, C., et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 108 (2011), 7535–7540.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
-
45
-
-
84876412641
-
MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma: molecular analysis of 25 ALK-positive cases
-
45 Boland, J.M., Jang, J.S., Li, J., et al. MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma: molecular analysis of 25 ALK-positive cases. J Thorac Oncol 8 (2013), 574–581.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 574-581
-
-
Boland, J.M.1
Jang, J.S.2
Li, J.3
-
46
-
-
84888145792
-
Concomitant occurrence of EGFR (epidermal growth factor receptor) and KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations in an ALK (anaplastic lymphoma kinase)-positive lung adenocarcinoma patient with acquired resistance to crizotinib: a case report
-
46 Rossing, H.H., Grauslund, M., Urbanska, E.M., et al. Concomitant occurrence of EGFR (epidermal growth factor receptor) and KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations in an ALK (anaplastic lymphoma kinase)-positive lung adenocarcinoma patient with acquired resistance to crizotinib: a case report. BMC Res Notes, 6, 2013, 489.
-
(2013)
BMC Res Notes
, vol.6
, pp. 489
-
-
Rossing, H.H.1
Grauslund, M.2
Urbanska, E.M.3
-
47
-
-
84899887245
-
Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer
-
47 Ji, C., Zhang, L., Cheng, Y., et al. Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer. Cancer Biol Ther 15 (2014), 570–577.
-
(2014)
Cancer Biol Ther
, vol.15
, pp. 570-577
-
-
Ji, C.1
Zhang, L.2
Cheng, Y.3
-
48
-
-
84961595143
-
Transformation to small-cell lung cancer as a mechanism of acquired resistance to crizotinib and alectinib
-
48 Miyamoto, S., Ikushima, S., Ono, R., et al. Transformation to small-cell lung cancer as a mechanism of acquired resistance to crizotinib and alectinib. Jpn J Clin Oncol 46 (2016), 170–173.
-
(2016)
Jpn J Clin Oncol
, vol.46
, pp. 170-173
-
-
Miyamoto, S.1
Ikushima, S.2
Ono, R.3
-
49
-
-
84903466222
-
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
-
49 Friboulet, L., Li, N., Katayama, R., et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 4 (2014), 662–673.
-
(2014)
Cancer Discov
, vol.4
, pp. 662-673
-
-
Friboulet, L.1
Li, N.2
Katayama, R.3
-
50
-
-
84937521317
-
PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to first and second generation ALK inhibitors in preclinical models
-
50 Zou, H.Y., Friboulet, L., Kodack, D.P., et al. PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to first and second generation ALK inhibitors in preclinical models. Cancer Cell 28 (2015), 70–81.
-
(2015)
Cancer Cell
, vol.28
, pp. 70-81
-
-
Zou, H.Y.1
Friboulet, L.2
Kodack, D.P.3
-
51
-
-
84925307919
-
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
-
51 Zou, H.Y., Li, Q., Engstrom, L.D., et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc Natl Acad Sci U S A 112 (2015), 3493–3498.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 3493-3498
-
-
Zou, H.Y.1
Li, Q.2
Engstrom, L.D.3
-
52
-
-
84954050562
-
Resensitization to crizotinib by the lorlatinib ALK resistance mutation L1198F
-
52 Shaw, A.T., Friboulet, L., Leshchiner, I., et al. Resensitization to crizotinib by the lorlatinib ALK resistance mutation L1198F. N Engl J Med 374 (2016), 54–61.
-
(2016)
N Engl J Med
, vol.374
, pp. 54-61
-
-
Shaw, A.T.1
Friboulet, L.2
Leshchiner, I.3
-
53
-
-
84946795025
-
Alka-372-001: first-in-human, phase I study of entrectinib—an oral pan-TRK, ROS1, and ALK inhibitor—in patients with advanced solid tumors with relevant molecular alterations
-
abstract 2517
-
53 De Braud, F., Niger, M., Damian, S., et al. Alka-372-001: first-in-human, phase I study of entrectinib—an oral pan-TRK, ROS1, and ALK inhibitor—in patients with advanced solid tumors with relevant molecular alterations. J Clin Oncol, 33(suppl), 2015 abstract 2517.
-
(2015)
J Clin Oncol
, vol.33
-
-
De Braud, F.1
Niger, M.2
Damian, S.3
-
54
-
-
84859400151
-
CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers
-
54 Cheng, M., Quail, M.R., Gingrich, D.E., et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther 11 (2012), 670–679.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 670-679
-
-
Cheng, M.1
Quail, M.R.2
Gingrich, D.E.3
-
55
-
-
0024271627
-
Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis
-
55 Sorensen, J.B., Hansen, H.H., Hansen, M., Dombernowsky, P., Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis. J Clin Oncol 6 (1988), 1474–1480.
-
(1988)
J Clin Oncol
, vol.6
, pp. 1474-1480
-
-
Sorensen, J.B.1
Hansen, H.H.2
Hansen, M.3
Dombernowsky, P.4
-
56
-
-
84863020427
-
Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
-
56 Sperduto, P.W., Kased, N., Roberge, D., et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 30 (2012), 419–425.
-
(2012)
J Clin Oncol
, vol.30
, pp. 419-425
-
-
Sperduto, P.W.1
Kased, N.2
Roberge, D.3
-
57
-
-
84924579040
-
Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers
-
57 Rangachari, D., Yamaguchi, N., VanderLaan, P.A., et al. Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers. Lung Cancer 88 (2015), 108–111.
-
(2015)
Lung Cancer
, vol.88
, pp. 108-111
-
-
Rangachari, D.1
Yamaguchi, N.2
VanderLaan, P.A.3
-
58
-
-
79957487193
-
CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
-
58 Costa, D.B., Kobayashi, S., Pandya, S.S., et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol 29 (2011), e443–e445.
-
(2011)
J Clin Oncol
, vol.29
, pp. e443-e445
-
-
Costa, D.B.1
Kobayashi, S.2
Pandya, S.S.3
-
59
-
-
84954318418
-
Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis
-
59 Johung, K.L., Yeh, N., Desai, N.B., et al. Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis. J Clin Oncol 34 (2016), 123–129.
-
(2016)
J Clin Oncol
, vol.34
, pp. 123-129
-
-
Johung, K.L.1
Yeh, N.2
Desai, N.B.3
-
60
-
-
84929508050
-
Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases
-
60 Costa, D.B., Shaw, A.T., Ou, S.H., et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases. J Clin Oncol 33 (2015), 1881–1888.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1881-1888
-
-
Costa, D.B.1
Shaw, A.T.2
Ou, S.H.3
-
61
-
-
84930005738
-
Overall and intracranial (IC) efficacy results and time to symptom deterioration in PROFILE 1014: 1st-line crizotinib vs pemetrexed-platinum chemotherapy (PPC) in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC)
-
61 Solomon, B., Felip, E., Blackhall, F., et al. Overall and intracranial (IC) efficacy results and time to symptom deterioration in PROFILE 1014: 1st-line crizotinib vs pemetrexed-platinum chemotherapy (PPC) in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC). Ann Oncol 25 (2014), iv426–iv470.
-
(2014)
Ann Oncol
, vol.25
, pp. iv426-iv470
-
-
Solomon, B.1
Felip, E.2
Blackhall, F.3
-
62
-
-
84919779490
-
Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases
-
62 Kodama, T., Hasegawa, M., Takanashi, K., Sakurai, Y., Kondoh, O., Sakamoto, H., Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol 74 (2014), 1023–1028.
-
(2014)
Cancer Chemother Pharmacol
, vol.74
, pp. 1023-1028
-
-
Kodama, T.1
Hasegawa, M.2
Takanashi, K.3
Sakurai, Y.4
Kondoh, O.5
Sakamoto, H.6
-
63
-
-
84958956983
-
Alectinib dose escalation reinduces central nervous system responses in patients with anaplastic lymphoma kinase-positive non-small cell lung cancer relapsing on standard dose alectinib
-
63 Gainor, J.F., Chi, A.S., Logan, J., et al. Alectinib dose escalation reinduces central nervous system responses in patients with anaplastic lymphoma kinase-positive non-small cell lung cancer relapsing on standard dose alectinib. J Thorac Oncol 11 (2016), 256–260.
-
(2016)
J Thorac Oncol
, vol.11
, pp. 256-260
-
-
Gainor, J.F.1
Chi, A.S.2
Logan, J.3
-
64
-
-
84876354373
-
Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement
-
64 Takeda, M., Okamoto, I., Nakagawa, K., Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement. J Thorac Oncol 8 (2013), 654–657.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 654-657
-
-
Takeda, M.1
Okamoto, I.2
Nakagawa, K.3
-
65
-
-
84870317390
-
Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
-
65 Weickhardt, A.J., Scheier, B., Burke, J.M., et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol 7 (2012), 1807–1814.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1807-1814
-
-
Weickhardt, A.J.1
Scheier, B.2
Burke, J.M.3
-
66
-
-
84983373947
-
NCCN Clinical Practice Guidelines in Oncology. Non-Small Cell Lung Cancer version 4
-
Available at: Accessed: January 18, 2016
-
66 National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Non-Small Cell Lung Cancer version 4. 2016 Available at: http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf Accessed: January 18, 2016.
-
(2016)
-
-
-
67
-
-
84893399587
-
Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
-
67 Ou, S.H., Janne, P.A., Bartlett, C.H., et al. Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC. Ann Oncol 25 (2014), 415–422.
-
(2014)
Ann Oncol
, vol.25
, pp. 415-422
-
-
Ou, S.H.1
Janne, P.A.2
Bartlett, C.H.3
-
68
-
-
84955293624
-
Clinical impact of sequential treatment with ALK-TKIs in patients with advanced ALK-positive non-small cell lung cancer: results of a multicenter analysis
-
68 Chiari, R., Metro, G., Iacono, D., et al. Clinical impact of sequential treatment with ALK-TKIs in patients with advanced ALK-positive non-small cell lung cancer: results of a multicenter analysis. Lung Cancer 90 (2015), 255–260.
-
(2015)
Lung Cancer
, vol.90
, pp. 255-260
-
-
Chiari, R.1
Metro, G.2
Iacono, D.3
-
69
-
-
84857507055
-
Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial
-
69 Paz-Ares, L., de Marinis, F., Dediu, M., et al. Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial. Lancet Oncol 13 (2012), 247–255.
-
(2012)
Lancet Oncol
, vol.13
, pp. 247-255
-
-
Paz-Ares, L.1
de Marinis, F.2
Dediu, M.3
-
70
-
-
84876507123
-
Pemetrexed-based chemotherapy in patients with advanced, ALK-positive non-small cell lung cancer
-
70 Shaw, A.T., Varghese, A.M., Solomon, B.J., et al. Pemetrexed-based chemotherapy in patients with advanced, ALK-positive non-small cell lung cancer. Ann Oncol 24 (2013), 59–66.
-
(2013)
Ann Oncol
, vol.24
, pp. 59-66
-
-
Shaw, A.T.1
Varghese, A.M.2
Solomon, B.J.3
-
71
-
-
84941413820
-
Survival benefit of pemetrexed in lung adenocarcinoma patients with anaplastic lymphoma kinase gene rearrangements
-
71 Park, S., Park, T.S., Choi, C.M., et al. Survival benefit of pemetrexed in lung adenocarcinoma patients with anaplastic lymphoma kinase gene rearrangements. Clin Lung Cancer 16 (2015), e83–e89.
-
(2015)
Clin Lung Cancer
, vol.16
, pp. e83-e89
-
-
Park, S.1
Park, T.S.2
Choi, C.M.3
-
72
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
72 Whitesell, L., Lindquist, S.L., HSP90 and the chaperoning of cancer. Nat Rev Cancer 5 (2005), 761–772.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
73
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
73 Trepel, J., Mollapour, M., Giaccone, G., Neckers, L., Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 10 (2010), 537–549.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
74
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
74 Neckers, L., Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8 (2002), S55–S61.
-
(2002)
Trends Mol Med
, vol.8
, pp. S55-S61
-
-
Neckers, L.1
-
75
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
-
75 Chen, Z., Sasaki, T., Tan, X., et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res 70 (2010), 9827–9836.
-
(2010)
Cancer Res
, vol.70
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
-
76
-
-
79957896979
-
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models
-
76 Normant, E., Paez, G., West, K.A., et al. The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models. Oncogene 30 (2011), 2581–2586.
-
(2011)
Oncogene
, vol.30
, pp. 2581-2586
-
-
Normant, E.1
Paez, G.2
West, K.A.3
-
77
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
77 Sequist, L.V., Gettinger, S., Senzer, N.N., et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 28 (2010), 4953–4960.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
-
78
-
-
84877679409
-
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
-
78 Sang, J., Acquaviva, J., Friedland, J.C., et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov 3 (2013), 430–443.
-
(2013)
Cancer Discov
, vol.3
, pp. 430-443
-
-
Sang, J.1
Acquaviva, J.2
Friedland, J.C.3
-
79
-
-
84878971581
-
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
-
79 Socinski, M.A., Goldman, J., El-Hariry, I., et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res 19 (2013), 3068–3077.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3068-3077
-
-
Socinski, M.A.1
Goldman, J.2
El-Hariry, I.3
-
80
-
-
84866382273
-
Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC)
-
abstract 7543
-
80 Garon, E., Moran, T., Barlesi, F., et al. Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC). J Clin Oncol, 30(suppl), 2012 abstract 7543.
-
(2012)
J Clin Oncol
, vol.30
-
-
Garon, E.1
Moran, T.2
Barlesi, F.3
-
81
-
-
84868109046
-
ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma
-
81 Ilie, M., Long, E., Butori, C., et al. ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma. Ann Oncol 23 (2012), 2907–2913.
-
(2012)
Ann Oncol
, vol.23
, pp. 2907-2913
-
-
Ilie, M.1
Long, E.2
Butori, C.3
-
82
-
-
84883027282
-
Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer
-
82 Pailler, E., Adam, J., Barthelemy, A., et al. Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer. J Clin Oncol 31 (2013), 2273–2281.
-
(2013)
J Clin Oncol
, vol.31
, pp. 2273-2281
-
-
Pailler, E.1
Adam, J.2
Barthelemy, A.3
-
83
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
83 Newman, A.M., Bratman, S.V., To, J., et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med 20 (2014), 548–554.
-
(2014)
Nat Med
, vol.20
, pp. 548-554
-
-
Newman, A.M.1
Bratman, S.V.2
To, J.3
-
84
-
-
84995573375
-
Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer
-
84 Nilsson, R.J., Karachaliou, N., Berenguer, J., et al. Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer. Oncotarget 7 (2016), 1066–1075.
-
(2016)
Oncotarget
, vol.7
, pp. 1066-1075
-
-
Nilsson, R.J.1
Karachaliou, N.2
Berenguer, J.3
-
85
-
-
84921445453
-
The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population
-
85 Skov, B.G., Hogdall, E., Clementsen, P., et al. The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population. APMIS 123 (2015), 108–115.
-
(2015)
APMIS
, vol.123
, pp. 108-115
-
-
Skov, B.G.1
Hogdall, E.2
Clementsen, P.3
-
86
-
-
84994488352
-
-
Efficacy of pembrolizumab in key subgroups of patients with advanced NSCLC. Presented at the 16th World Conference on Lung Cancer, 2015; abstract 3057.
-
86 Hellmann M, Garon E, Gandhi L, et al. Efficacy of pembrolizumab in key subgroups of patients with advanced NSCLC. Presented at the 16th World Conference on Lung Cancer, 2015; abstract 3057.
-
-
-
Hellmann, M.1
Garon, E.2
Gandhi, L.3
-
87
-
-
84901191153
-
Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer
-
87 Djalalov, S., Beca, J., Hoch, J.S., et al. Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer. J Clin Oncol 32 (2014), 1012–1019.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1012-1019
-
-
Djalalov, S.1
Beca, J.2
Hoch, J.S.3
|