Transplacental and lactational transfer of firemaster® 550 components in dosed wistar rats

Toxicological Sciences

Volumn 153, Issue 2, 2016, Pages 246-257

  Phillips, Allison L ^a   Chen, Albert ^a   Rock, Kylie D ^b   Horman, Brian ^b   Patisaul, Heather B ^b   Stapleton, Heather M ^a  

^a DUKE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Firemaster 550; Gestational transfer; Lactational transfer; Metabolites; Rodent

Indexed keywords

BROMINE; ENDOCRINE DISRUPTOR; FLAME RETARDANT; ORGANOPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; DEVELOPMENTAL TOXICITY; FEMALE; GESTATIONAL AGE; GROWTH; LACTATION; NONHUMAN; PLACENTAL TRANSFER; PRENATAL EXPOSURE; RAT; TISSUE HOMOGENATE; TISSUE LEVEL; URINE LEVEL; URINE SAMPLING; WISTAR RAT; ANIMAL; DOSE RESPONSE; FETOMATERNAL TRANSFUSION; MALE; METABOLISM; PLACENTA; PREGNANCY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAME RETARDANTS; LACTATION; MALE; MATERNAL-FETAL EXCHANGE; PLACENTA; PREGNANCY; RATS; RATS, WISTAR;

EID: 84994500694     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw122     Document Type: Article

References (75)

1. Agatonovic-Kustrin, S., et al. (2002). Molecular descriptors that influence the amount of drugs transfer into human breast milk. J. Pharm. Biomed. Anal. 29, 103-119.
2. Ali, N., et al. (2011). "Novel" brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.
3. Ali, N., et al. (2012). Occurrence of alternative flame retardants in indoor dust from New Zealand: Indoor sources and human exposure assessment. Chemosphere 88, 1276-1282.
4. Al-Omran, L. S., and Harrad, S. (2015). Polybrominated diphenyl ethers and "novel" brominated flame retardants in floor and elevated surface house dust from Iraq: Implications for human exposure assessment. Emerg. Contam. 2, 7-13.
5. Antweiler, R. C., and Taylor, H. E. (2008). Evaluation of statistical treatments of left-censored environmental data using coincident uncensored data sets: I. Summary statistics. Environ. Sci. Technol. 42, 3732-3738.
6. Bain, L. J., and LeBlanc, G. A. (1996). Interaction of structurally diverse pesticides with thehuman MDR1 gene product P-glycoprotein. Toxicology and Applied Pharmacology. 141(1), 288-298.
7. Balakrishnan, B., et al. (2010). Transfer of bisphenol A across the human placenta. Am. J. Obstet. Gynecol. 202, 393.e1-e7.
8. Bearr, J. S., et al. (2010). Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, Firemaster 550 and Firemaster BZ-54. Environ. Toxicol. Chem. 29, 722-729.
9. Becker, M. M., and Gamble,W. (1982). Determination of the binding of 2,4,5,2',4',5'-hexachlorobiphenyl by low density lipoprotein and bovine serum albumin. J. Toxicol. Environ. Health 9, 225-234.
10. Behl, M., et al. (2015). Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol. Teratol. 52, 181-193.
11. Boeniger, M. F., Lowry, L. K., and Rosenberg, J. (1993). Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review. American Industrial Hygiene Association Journal. 54, 615-627.
12. Butt, C. M., et al. (2014). Metabolites of organophosphate flame retardants and 2-ethylhexyl tetrabromobenzoate in urine from paired mothers and toddlers. Environ. Sci. Technol. 48, 10432-10438.
13. Butt, C. M., et al. (2016). Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum. Anal. Bioanal. Chem. 408, 2449-2459.
14. Cao, J., et al. (2015). Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring. Reprod. Toxicol. 58, 282-294.
15. Clewell, R. a., and Gearhart, J. M. (2002). Pharmacokinetics of toxic chemicals in breast milk: Use of PBPK models to predict infant exposure. Environ. Health Perspect. 110, 333-337.
16. Cooper, E. M., et al. (2011). Analysis of the flame retardant metabolites bis (1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 401, 2123-2132.
17. Dodson, R. E., et al. (2014). Urinary biomonitoring of phosphate flame retardants: Levels in california adults and recommendations for future studies. Environ. Sci. Technol. 48, 13625-13633.
18. Fang, M., et al. (2015). Characterizing the peroxisome proliferator-activated receptor (PPARc) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environ. Health Perspect. 123, 166-172.
19. Fang, M., and Stapleton, H. M. (2014). Evaluating the bioaccessibility of flame retardants in house dust using an in vitro tenax bead-assisted sorptive physiologically based method. Environ. Sci. Technol. 48, 13323-13330.
20. Gallenberg, L. A., and Vodicnik, M. J. (1987). Potential mechanisms for redistribution of polychlorinated biphenyls during pregnancy and lactation. Xenobiotica 1717, 299-310.
21. Gómara, B., et al. (2007). Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain. Environ. Sci. Technol. 41, 6961-6968.
22. Greaves, A. K., and Letcher, R. J. (2014). Comparative body compartment composition and in ovo transfer of organophosphate flame retardants in North American Great Lakes herring gulls. Environ. Sci. Technol. 48, 7942-7950.
23. Hodgson, E. (2012). Introduction to Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition. 1-3.
24. Hamosh, M., et al. (1970). Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride pregnant and lactating rats. Biochim. Biophys. Acta 210, 473-482.
25. Hoffman, K., et al. (2014). Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture FiremasterVR 550. Environ. Health Perspect. 122, 963-969.
26. Hoffman, K., et al. (2015). High exposure to organophosphate flame retardants in infants: Associations with baby products. Environ. Sci. Technol. 49, 14554-14559.
27. Hunt, P. A., et al. (2009). The bisphenol A experience: A primer for the analysis of environmental effects on mammalian reproduction. Biol. Reprod. 81, 807-813.
28. Iverson, S. J., et al. (1995). Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey seals. J. Comp. Physiol. B. 165, 384-395.
29. Johnson, P. I., et al. (2010). Relationships between polybrominated diphenyl ether concentrations in house dust and serum. Environ. Sci. Technol. 44, 5627-5632.
30. Kim, J. W., et al. (2014). Organophosphorus flame retardants (PFRs) in human breast milk from several Asian countries. Chemosphere 116, 91-97.
31. Kim, S., et al. (2015). Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat. Toxicol. 160, 188-196.
32. Klosterhaus, S., et al. (2009) Characterization of organophosphorous chemicals in a PentaBDE replacement mixture and their detection in biosolids. Poster presentation, 11th Annual Workshop on Brominated Flame Retardants, Ottawa, Ontario, Canada.
33. Knudsen, G. A., Sanders, J. M., and Birnbaum, L. S. (2016). Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: Effects of dose, route and repeated administration. Xenobiotica 1-10. doi:10.1080/00498254.2016.1174793.
34. Lam, J. C. W., et al. (2009). Temporal trends of hexabromocyclododecanes (HBCDs) and polybrominated diphenyl ethers (PBDEs) and detection of two novel flame retardants in marine mammals from Hong Kong, South China. Environ. Sci. Technol. 43, 6944-6949.
35. Lew, B. J., et al. (2009). Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation. Toxicol. Sci. 111, 151-162.
36. Li, A. A., et al. (2008). Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system. Neurotoxicology 29, 504-519.
37. Liu, L. Y., et al. (2015). Analysis of polybrominated diphenyl ethers and emerging halogenated and organophosphate flame retardants in human hair and nails. J. Chromatogr. A 1406, 251-257.
38. Lyche, J. L., et al. (2004). Levels of PCB 126 and PCB 153 in plasma and tissues in goats exposed during gestation and lactation. Chemosphere 55, 621-629.
39. Maliwal, B. P., and Guthrie, F. E. (1982). In vitro uptake and transfer of chlorinated hydrocarbons among human lipoproteins. J. Lipid Res. 23, 474-479.
40. Mühlebach, S., et al. (1991). The use of 2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) as an unmetabolizable lipophilic model compound. Pharmacol. Toxicol. 69, 410-415.
41. Nakashima, Y., et al. (1997). Hexachlorobenzene accumulated by dams during pregnancy is transferred to suckling rats during early lactation. J. Nutr. 127, 648-654.
42. Parker, C. R., et al. (1983). Analysis of the potential for transfer of lipoprotein-cholesterol across the human placenta. Early Hum. Dev. 8, 289-295.
43. Patisaul, H. B., et al. (2013). Accumulation and endocrine disrupting effects of the flame retardant mixture FiremasterVR 550 in rats: An exploratory assessment. J. Biochem. Mol. Toxicol. 27, 124-136.
44. Patisaul, H. B., et al. (2012). Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy. PLoS One 7, e43890.
45. Patisaul, H. B., et al. (2009). Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. Neurotoxicology 30, 350-357.
46. Pillai, H. K., et al. (2014). Ligand binding and activation of PPARc by Firemaster 550: Effects on adipogenesis and osteogenesis in vitro. Environ. Health Perspect. 122, 1225-1232.
47. Richter, C. A., et al. (2007). In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol. 24, 199-224.
48. Roberts, S. C., et al. (2012). In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues. Chem. Res. Toxicol. 25, 1435-1441.
49. Rudel, R. A., et al. (2011). Environmental exposures and mammary gland development: State of the science, public health implications, and research recommendations. Environ. Health Perspect. 119, 1053-1061.
50. Salamova, A., et al. (2014). Organophosphate and halogenated flame retardants in atmospheric particles from a European Arctic site. Environ. Sci. Technol. 48, 6133-6140.
51. Sasaki, K., et al. (1984). Metabolism of phosphoric acid triesters by rat liver homogenate. Bull. Environ. Contam. Toxicol. 33, 281-288.
52. Saunders, D. M. V., et al. (2013). In vitro endocrine disruption and TCDD-like effects of three novel brominated flame retardants: TBPH, TBB, & TBCO. Toxicol. Lett. 223, 252-259.
53. Schecter, A., Colacino, J., Sjödin, A., Needham, L., and Birnbaum, L. (2010). Partitioning of polybrominated diphenyl ethers (PBDEs) in serum and milk from the same mothers. Chemosphere 78, 1279-1284.
54. Shen, H., et al. (2007). From mother to child: Investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere 67, S256-S262.
55. Silva, M. J., et al. (2015). Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45. Arch. Toxicol. 90, 551-557.
56. Slone, E. J., et al. (2012). Estimation of individual rodent water consumption from group consumption data for gestation, lactation, and postweaning life stages using linear regression models. Ilar J. 53, E99-112.
57. Spindler-Vomachka, M., and Vodicnik, M. J. (1984). Distribution of 2,4,5,2',4',5'-hexachlorobiphenyl among lipoproteins during pregnancy and lactation in the rat. J. Pharmacol. Exp. Ther. 230, 263-268.
58. Stapleton, H. M., et al. (2008). Alternate and new brominated flame retardants detected in U.S. house dust. Environ. Sci. Technol. 42, 6910-6916.
59. Stapleton, H. M., et al. (2009). Detection of organophosphate flame retardants in furniture foam and U.S. house dust. Environ. Sci. Technol. 43, 7490-7495.
60. Stapleton, H. M., et al. (2012a). Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out. Environ. Sci. Technol. 46, 13432-13439.
61. Stapleton, H. M., et al. (2012b). Serum PBDEs in a North Carolina toddler cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054.
62. Sundkvist, A. M., et al. (2010). Organophosphorus flame retardants and plasticizers in marine and fresh water biota and in human milk. J. Environ. Monit. 12, 943-951.
63. U.S. Environmental Protection Agency. Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available at http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm. Accessed November 18, 2014.
64. U.S. Environmental Protection Agency. TSCA Work Plan for Chemical Assessments: 2014 Update. Available at http://www.epa.gov/sites/production/files/2015-01/documents/tsca_work_plan_chemicals_2014_update-final.pdf. Accessed February 8, 2016.
65. Van den Eede, N., et al. (2014). Age as a determinant of phosphate flame retardant exposure of the Australian population and identification of novel urinary PFR metabolites. Environ. Int. 74, 1-8.
66. Van den Eede, N., Dirtu, A. C., Ali, N., Neels, H., and Covaci, A. (2012). Multi-residue method for the determination of brominated and organophosphate flame retardants in indoor dust. Talanta 89, 292-300.
67. Van den Eede, N., Maho, W., et al. (2013a). First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions. Toxicol. Lett. 223, 9-15.
68. Van den Eede, N., Neels, H., et al. (2013b). Analysis of organophosphate flame retardant diester metabolites in human urine by liquid chromatography electrospray ionisation tandem mass spectrometry. J. Chromatogr. A 1303, 48-53.
69. Van Esch, G. J., et alet. al. (1997). Flame retardants: A general introduction. Environmental Health Criteria, Vol. 192. IPCS, WHO, Geneva.
70. Vorderstrasse, B. A., et al. (2004). A novel effect of dioxin: Exposure during pregnancy severely impairs mammary gland differentiation. Toxicol. Sci. 78, 248-257.
71. Wolff, M. S. (1983). Occupationally derived chemicals in breast milk. Am. J. Ind. Med. 4, 259-281.
72. World Health Organization. (1990). United Nations Environment Programme., International Labour Organisation., World Health Organization., & International Program on Chemical Safety. Tricresyl phosphate, p. 122.
73. You, L., et al. (1999). Transplacental and lactational transfer of p,p0-DDE in Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 157, 134-144.
74. Zhu, B., et al. (2014). Changes of accumulation profiles from PBDEs to brominated and chlorinated alternatives in marine mammals from the South China Sea. Environ. Int. 66, 65-70.
75. Zhou, S. N., et al. (2014). Measurements of selected brominated flame retardants in nursing women: Implications for human exposure. Environ. Sci. Technol. 48, 8873-8880.