Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust

Environmental Health Perspectives

Volumn 123, Issue 2, 2015, Pages 166-172

  Fang, Mingliang ^a   Webster, Thomas F ^b   Ferguson, P Lee ^a   Stapleton, Heather M ^a  

^a DUKE UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; 2,2',4,4',5 PENTABROMODIPHENYL; 2,4,6 TRIBROMOPHENOL; 2,4,6 TRIIODOPHENOL; 2,4,6, TRICHLOROPHENOL; 3 HYDROXY 2,2',4,4' PENTABROMODIPHENYL ETHER; 3,3',5,5' TETRACHLOROBISPHENOL A; 4,4' ISOPROPYLIDENEDIPHENOL; BIS(2 ETHYLHEXYL) TETRABROMOPHTHALATE; DIPHENYL PHOSPHATE; DITHIOTHREITOL; FLAME RETARDANT; HALOPHENOL; ISOPROPYLATED TRIARYL PHOSPHATE; MONO(2 ETHYLHEXYL) TETRABROMOPHTHALATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; POLYBROMINATED DIPHENYL ETHER; ROSIGLITAZONE; TETRABROMO MONO(2 ETHYLHEXYL)PHTHALATE; TETRABROMOBISPHENOL A; TRIBUTYL PHOSPHATE; TRIBUTYLTIN; TRICLOSAN; TRIPHENYL PHOSPHATE; TRIPHENYLPHOSPHITE; TRIPHENYLTIN; TRIS(2 BUTOXYETHYL) PHOSPHATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; DIPHENYL ETHER DERIVATIVE; DUST; HALOGENATED HYDROCARBON; LIGAND;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DUST SAMPLING; ENVIRONMENTAL EXPOSURE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GEL PERMEATION CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HOUSE DUST; HYDROXYLATION; IC50; INDOOR AIR POLLUTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; SAMPLING; ANALYSIS; ANIMAL; BIOASSAY; CHEMICAL MODEL; CHEMISTRY; DUST; ENZYMOLOGY; HUMAN; LIVER; METABOLISM;

RATTUS;

ANIMALS; BIOLOGICAL ASSAY; DUST; FLAME RETARDANTS; HALOGENATED DIPHENYL ETHERS; HUMANS; HYDROCARBONS, HALOGENATED; LIGANDS; LIVER; MODELS, CHEMICAL; PPAR GAMMA; RATS;

EID: 84923015812     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408522.     Document Type: Article

References (33)

1. Carignan CC, Heiger-Bernays W, McClean MD, Roberts SC, Stapleton HM, Sjödin A, et al. 2013a. Flame retardant exposure among collegiate United States gymnasts. Environ Sci Technol 47(23):13848–13856.
2. Carignan CC, McClean MD, Cooper EM, Watkins DJ, Fraser AJ, Heiger-Bernays W, et al. 2013b. Predictors of tris(1,3-dichloro-2-propyl) phosphate metabolite in the urine of office workers. Environ Int 55:56–61.
3. Cooper EM, Covaci A, van Nuijs ALN, Webster TF, Stapleton HM. 2011. Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography–tandem mass spectrometry. Anal Bioanal Chem 401(7):2123–2132.
4. Dodson RE, Perovich LJ, Covaci A, Van den Eede N, Ionas AC, Dirtu AC, et al. 2012. After the PBDE phase-out: a broad suite of flame retardants in repeat house dust samples from California. Environ Sci Technol 46(24):13056–13066.
5. Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, et al. 2007. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor γ modu-lator that promotes adipogenesis. J Biol Chem 282(26):19152–19166.
6. Grün F, Blumberg B. 2009. Endocrine disrupters as obesogens. Mol Cell Endocrinol 304(1–2):19–29.
7. Hoffman K, Fang M, Horman B, Patisaul HB, Garantziotis S, Birnbaum LS, et al. 2014. Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550. Environ Health Perspect 122:963–969; doi:10.1289/ehp.1308028.
8. Janesick A, Blumberg B. 2011. Minireview: PPARγ as the target of obesogens. J Steroid Biochem Mol Biol 127(1–2):4–8.
9. Kannan K, Takahashi S, Fujiwara N, Mizukawa H, Tanabe S. 2010. Organotin compounds, including butyltins and octyltins, in house dust from Albany, New York, USA. Arch Environ Contam Toxicol 58(4):901–907.
10. Lin Q, Ruuska SE, Shaw NS, Dong D, Noy N. 1999. Ligand selectivity of the peroxisome proliferator- activated receptor α. Biochemistry 38(1):185–190.
11. Lu C, Cheng SY. 2010. Thyroid hormone receptors regulate adipogenesis and carcino genesis via crosstalk signaling with peroxisome proliferator- activated receptors. J Mol Endocrinol 44(3):143–154.
12. Meeker JD, Cooper EM, Stapleton HM, Hauser R. 2013. Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environ Health Perspect 121:580–585; doi:10.1289/ehp.1205907.
13. Meerts IATM, van Zanden JJ, Luijks EAC, van Leeuwen-Bol I, Marsh G, Jakobsson E, et al. 2000. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 56(1):95–104.
14. Ness-Abramof R, Apovian CM. 2005. Drug-induced weight gain. Timely Top Med Cardiovasc Dis 9:E31; doi:10.1358/dot.2005.41.8.893630.
15. Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, et al. 1998. Ligand binding and co-activator assembly of the peroxi some proliferator- activated receptor-γ. Nature 395(6698):137–143.
16. Noyes PD, Hinton DE, Stapleton HM. 2011. Accumulation and debromination of decabromo-diphenyl ether (BDE-209) in juvenile fathead minnows (Pimephales promelas) induces thyroid disruption and liver alterations. Toxicol Sci 122(2):265–274.
17. Ogden CL, Carroll MD, Kit BK, Flegal KM. 2012. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA 307(5):483–490.
18. Patisaul HB, Roberts SC, Mabrey N, McCaffrey KA, Gear RB, Braun J, et al. 2013. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. J Biochem Mol Toxicol 27(2):124–136.
19. Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, et al. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis. Environ Health Perspect 122:1225-32; doi:10.1289/ehp.1408111.
20. Qiu X, Mercado-Feliciano M, Bigsby RM, Hites RA. 2007. Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture. Environ Health Perspect 115:1052–1058; doi:10.1289/ehp.10011.
21. Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, et al. 2011. Peroxisome proliferator- activated receptor γ is a target for halogenated analogs of bisphenol A. Environ Health Perspect 119:1227–1232; doi:10.1289/ehp.1003328.
22. Roberts SC, Macaulay LJ, Stapleton HM. 2012. In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues. Chem Res Toxicol 25(7):1435–1441.
23. Rossi AM, Taylor CW. 2011. Analysis of protein-ligand interactions by fluorescence polarization. Nat Protoc 6(3):365–387.
24. Rudel RA, Camann DE, Spengler JD, Korn LR, Brody JG. 2003. Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine- disrupting compounds in indoor air and dust. Environ Sci Technol 37(20):4543–4553.
25. Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, et al. 2012. Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2- ethylhexyl) tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust. Environ Health Perspect 120:1711–1719; doi:10.1289/ehp.1204932.
26. Stapleton HM, Eagle S, Sjödin A, Webster TF. 2012. Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables. Environ Health Perspect 120:1049–1054; doi:10.1289/ehp.1104802.
27. Stapleton HM, Misenheimer J, Hoffman K, Webster TF. 2014. Flame retardant associations between children’s handwipes and house dust. Chemosphere 116:54–60.
28. Suzuki G, Tue NM, Malarvannan G, Sudaryanto A, Takahashi S, Tanabe S, et al. 2013. Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteo-sarcoma (U2OS) cell-based reporter gene assays. Environ Sci Technol 47(6):2898–2908.
29. Tang-Péronard JL, Andersen HR, Jensen TK, Heitmann BL. 2011. Endocrine-disrupting chemicals and obesity development in humans: a review. Obes Rev 12(8):622–636.
30. U.S. EPA (U.S. Environmental Protection Agency). 2009. Child-Specific Exposure Factors Handbook. Interim Report. Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=55145 [accessed 17 December 2012].
31. Van den Eede N, Dirtu AC, Neels H, Covaci A. 2011. Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust. Environ Int 37(2):454–461.
32. Wang H, Zhou Y, Tang C, He Y, Wu J, Chen Y, et al. 2013. Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children. PloS one 8(2):e56800; doi:10.1371/journal.pone.0056800.
33. Watkins DJ, McClean MD, Fraser AJ, Weinberg J, Stapleton HM, Webster TF. 2013. Associations between PBDEs in office air, dust, and surface wipes. Environ Int 59:124–132.