Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

Cardiovascular Drugs and Therapy

Volumn 30, Issue 6, 2016, Pages 539-550

  Birnbaum, Yochai ^a,b   Birnbaum, Gilad D ^b   Birnbaum, Itamar ^b   Nylander, Sven ^c   Ye, Yumei ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Adenosine; Diabetes mellitus; Infarct size; Ischemia reperfusion; Statin; Ticagrelor

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE; CRYOPYRIN; CYCLOOXYGENASE 2; GLUCOSE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOXIN A; MESSENGER RNA; PRASUGREL; ROSUVASTATIN; TICAGRELOR; ANTITHROMBOCYTIC AGENT; APOPTOSIS REGULATORY PROTEIN; CARDIOTONIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IL1B PROTEIN, RAT; LIPOXIN; NLRP3 PROTEIN, RAT; PTGS2 PROTEIN, RAT; PURINERGIC P2Y RECEPTOR ANTAGONIST; PYCARD PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HEART INFARCTION SIZE; HEART PROTECTION; IMMUNOBLOTTING; MALE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT DURATION; ZUCKER DIABETIC FATTY RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CARDIAC MUSCLE; DIABETES MELLITUS, EXPERIMENTAL; GENETICS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; OBESITY; ZUCKER RAT;

ADENOSINE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARDIOTONIC AGENTS; CYCLOOXYGENASE 2; DIABETES MELLITUS, EXPERIMENTAL; DRUG SYNERGISM; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOXINS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OBESITY; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS, ZUCKER; RNA, MESSENGER; ROSUVASTATIN CALCIUM;

EID: 84994434566     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-016-6701-2     Document Type: Article

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