A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

Diabetologia

Volumn 60, Issue 2, 2017, Pages 249-257

  Rawal, Shristi ^a   Hinkle, Stefanie N ^a   Bao, Wei ^b   Zhu, Yeyi ^a   Grewal, Jagteshwar ^a   Albert, Paul S ^a   Weir, Natalie L ^c   Tsai, Michael Y ^c   Zhang, Cuilin ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Ferritin; Gestational diabetes mellitus; Hepcidin; Iron overload; Soluble transferrin receptor; sTfR:ferritin ratio

Indexed keywords

FERRITIN; HEPCIDIN; IRON; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; ETHNICITY; FEMALE; FERRITIN BLOOD LEVEL; FETUS GROWTH; GESTATIONAL AGE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MEDICAL RECORD; MULTIRACIAL PERSON; NATIONAL HEALTH ORGANIZATION; POPULATION BASED CASE CONTROL STUDY; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RACE; RISK FACTOR; ADOLESCENT; BLOOD; CASE CONTROL STUDY; DIABETES, GESTATIONAL; IRON OVERLOAD; METABOLISM; YOUNG ADULT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; FEMALE; FERRITINS; HEPCIDINS; HUMANS; IRON; IRON OVERLOAD; LONGITUDINAL STUDIES; PREGNANCY; RECEPTORS, TRANSFERRIN; YOUNG ADULT;

EID: 84994431052     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4149-3     Document Type: Article

References (36)

1. Scholl TO, Reilly T (2000) Anemia, iron and pregnancy outcome. J Nutr 130:443S–447S
2. McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I (2015) Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U.S. Preventive Services Task Force recommendation. Agency for Healthcare Research and Quality, Rockville, MD, USA. Available from www.ncbi.nlm.nih.gov/books/NBK285986, accessed 6 September 2016
3. Hansen JB, Moen IW, Mandrup-Poulsen T (2014) Iron: the hard player in diabetes pathophysiology. Acta Physiol (Oxf) 210:717–732
4. Montonen J, Boeing H, Steffen A et al (2012) Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetologia 55:2613–2621
5. Zhao Z, Li S, Liu G et al (2012) Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis. PLoS One 7:e41641
6. Zein S, Rachidi S, Hininger-Favier I (2014) Is oxidative stress induced by iron status associated with gestational diabetes mellitus? J Trace Elem Med Biol 28:65–69
7. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE (2007) Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 30(Suppl 2):S112–S119
8. Zein S, Rachidi S, Awada S et al (2015) High iron level in early pregnancy increased glucose intolerance. J Trace Elem Med Biol 30:220–225
9. Khambalia AZ, Collins CE, Roberts CL et al (2016) Iron deficiency in early pregnancy using serum ferritin and soluble transferrin receptor concentrations are associated with pregnancy and birth outcomes. Eur J Clin Nutr 70:358–363
10. Tarim E, Kilicdag E, Bagis T, Ergin T (2004) High maternal hemoglobin and ferritin values as risk factors for gestational diabetes. Int J Gynaecol Obstet 84:259–261
11. Chen X, Scholl TO, Stein TP (2006) Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: the Camden study. Diabetes Care 29:1077–1082
12. Bowers KA, Olsen SF, Bao W, Halldorsson TI, Strom M, Zhang C (2016) Plasma concentrations of ferritin in early pregnancy are associated with risk of gestational diabetes mellitus in women in the Danish National Birth Cohort. J Nutr 146:1756–1761
13. Harms K, Kaiser T (2015) Beyond soluble transferrin receptor: old challenges and new horizons. Best Pract Res Clin Endocrinol Metab 29:799–810
14. Skikne BS, Flowers CH, Cook JD (1990) Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 75:1870–1876
15. Skikne BS (1998) Circulating transferrin receptor assay—coming of age. Clin Chem 44:7–9
16. Ganz T, Nemeth E (2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823:1434–1443
17. Young MF, Griffin I, Pressman E et al (2012) Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources. J Nutr 142:33–39
18. Derbent AU, Simavli SA, Kaygusuz I et al (2013) Serum hepcidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitus. J Matern Fetal Neonatal Med 26:1112–1115
19. Buck Louis GM, Grewal J, Albert PS et al (2015) Racial/ethnic standards for fetal growth: the NICHD Fetal Growth Studies. Am J Obstet Gynecol 213:449.e441
20. American College of Obstetricians and Gynecologists Committee on Practice Bulletins—Obstetrics (2001) ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes. Obstet Gynecol 98:525–538
21. Lao TT, Chan PL, Tam KF (2001) Gestational diabetes mellitus in the last trimester—a feature of maternal iron excess? Diabet Med 18:218–223
22. Amiri FN, Basirat Z, Omidvar S, Sharbatdaran M, Tilaki KH, Pouramir M (2013) Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med 4:302–305
23. Afkhami-Ardekani M, Rashidi M (2009) Iron status in women with and without gestational diabetes mellitus. J Diabetes Complicat 23:194–198
24. Soubasi V, Petridou S, Sarafidis K et al (2010) Association of increased maternal ferritin levels with gestational diabetes and intra-uterine growth retardation. Diabetes Metab 36:58–63
25. Sharifi F, Ziaee A, Feizi A, Mousavinasab N, Anjomshoaa A, Mokhtari P (2010) Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus. Diabetes Metab Syndr Obes 3:413–419
26. Javadian P, Alimohamadi S, Gharedaghi MH, Hantoushzadeh S (2014) Gestational diabetes mellitus and iron supplement; effects on pregnancy outcome. Acta Med Iran 52:385–389
27. Gungor ES, Danisman N, Mollamahmutoglu L (2007) Maternal serum ferritin and hemoglobin values in patients with gestational diabetes mellitus. Saudi Med J 28:478–480
28. Maitland RA, Seed PT, Briley AL et al (2014) Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial. Diabet Med 31:963–970
29. Khambalia AZ, Aimone A, Nagubandi P et al (2015) High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabet Med 33:1211–1221
30. Koenig MD, Tussing-Humphreys L, Day J, Cadwell B, Nemeth E (2014) Hepcidin and iron homeostasis during pregnancy. Nutrients 6:3062–3083
31. Walsh T, O’Broin SD, Cooley S et al (2011) Laboratory assessment of iron status in pregnancy. Clin Chem Lab Med 49:1225–1230
32. van Santen S, Kroot JJ, Zijderveld G, Wiegerinck ET, Spaanderman ME, Swinkels DW (2013) The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. Clin Chem Lab Med 51:1395–1401
33. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790:671–681
34. Fernandez-Real JM, McClain D, Manco M (2015) Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of type 2 diabetes. Diabetes Care 38:2169–2176
35. Facchini FS, Saylor KL (2002) Effect of iron depletion on cardiovascular risk factors: studies in carbohydrate-intolerant patients. Ann N Y Acad Sci 967:342–351
36. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W (2002) Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes 51:1000–1004