Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources

Journal of Nutrition

Volumn 142, Issue 1, 2012, Pages 33-39

  Young, Melissa F ^a   Griffin, Ian ^b   Pressman, Eva ^c   Mcintyre, Allison W ^c   Cooper, Elizabeth ^c   Mcnanley, Thomas ^c   Harris, Z Leah ^d   Westerman, Mark ^e   O'Brien, Kimberly O ^a  

^a Department of Obstetrics Gynecology   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e Intrinsic LifeSciences LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; ERYTHROPOIETIN; FERRIC SULFATE; FERRITIN; FOLIC ACID; HEME; HEMOGLOBIN; HEPCIDIN; IRON; IRON 57; IRON 58; LEPTIN; NONHEME IRON PROTEIN; RADIOISOTOPE; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IRON BLOOD LEVEL; IRON INTAKE; IRON STORAGE; LOW BIRTH WEIGHT; MATERNAL BLOOD; PLACENTAL TRANSFER; PREGNANT WOMAN; PROTEIN BLOOD LEVEL; THIRD TRIMESTER PREGNANCY; UMBILICAL CORD BLOOD; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; DIET; FEMALE; HEME; HUMANS; IRON; MATERNAL-FETAL EXCHANGE; PREGNANCY; YOUNG ADULT;

ANIMALIA;

EID: 84855555110     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.145961     Document Type: Article

References (46)

1. Siddappa AM, Rao R, Long JD, Widness JA, Georgieff MK. The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology. 2007;92:73-82.
2. Allen LH. Multiple micronutrients in pregnancy and lactation: an overview. Am J Clin Nutr. 2005;81:S1206-12.
3. Jaime-Perez JC, Herrera-Garza JL, Gomez-Almaguer D. Sub-optimal fetal iron acquisition under a maternal environment. Arch Med Res. 2005;36:598-602.
4. Lozoff B, Kaciroti N, Walter T. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr. 2006;84:1412-21.
5. Meinzen-Derr JK, Guerrero ML, Altaye M, Ortega-Gallegos H, Ruiz-Palacios GM, Morrow AL. Risk of infant anemia is associated with exclusive breast-feeding and maternal anemia in a Mexican cohort. J Nutr. 2006;136:452-8.
6. Lubach GR, Coe CL. Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). J Nutr. 2006;136:2345-9.
7. Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Proschel M. Identifying a window of vulnerability during fetal development in a maternal iron restriction model. PLoS ONE. 2011;6:e17483.
8. Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987;46:329-34.
9. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Longlasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64:S34-43.
10. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140:165-70.
11. O'Brien KO, Zavaleta N, Abrams SA, Caulfield LE. Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy. Am J Clin Nutr. 2003;77:924-30.
12. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783-8.
13. Millard KN, Frazer DM, Wilkins SJ, Anderson GJ. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut. 2004;53:655-60.
14. Nicolas G, BennounM, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA. 2002;99:4596-601.
15. Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, Harris ZL, Westerman M, O'Brien KO. Utilization of iron from an animal-based iron source is greater than that of ferrous sulfate in pregnant and nonpregnant women. J Nutr. 2010;140:2162-6.
16. Taylor PDP, Maeck R, De Bievre P. Determination of the absolute isotopic composition and atomic weight of a reference sample of natural iron. Int J Mass Spectrom Ion Process. 1992;121:111-25.
17. Etcheverry P, Carstens GE, Brown E, Hawthorne KM, Chen Z, Griffin IJ. Production of stable-isotope-labeled bovine heme and its use to measure heme-iron absorption in children. Am J Clin Nutr. 2007;85:452-9.
18. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101:3359-64.
19. Mei Z, Cogswell ME, Looker AC, Pfeiffer CM, Cusick SE, Lacher DA, Grummer-Strawn LM. Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. Am J Clin Nutr. 2011;93:1312-20.
20. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood. 2008;112:4292-7.
21. O'Brien KO, Zavaleta N, Caulfield LE, Yang DX, Abrams SA. Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian women. Am J Clin Nutr. 1999;69:509-15.
22. Linderkamp O, Versmold HT, Riegel KP, Betke K. Estimation and prediction of blood volume in infants and children. Eur J Pediatr. 1977;125:227-34.
23. Mollison PL, Veal N, Cutbush M. Red cell and plasma volume in newborn infants. Arch Dis Child. 1950;25:242.
24. Yergey AL, Abrams SA, Vieira NE, Aldroubi A, Marini J, Sidbury JB. Determination of fractional absorption of dietary calcium in humans. J Nutr. 1994;124:674-82.
25. Fomon SJ, Ziegler EE, Rogers RR, Nelson SE, Edwards BB, Guy DG, Erve JC, Janghorbani M. Iron absorption from infant foods. Pediatr Res. 1989;26:250-4.
26. Hahn PF, Carothers EL, Darby WJ, Martin M, Sheppard CW, Cannon RO, Bream AS, Densen PM, Peterson JC, McClellan GS. Iron metabolism in human pregnancy as studied with the radioactive isotope Fe59. Am J Obstet Gynecol. 1951;61:477-86.
27. Millard KN, Frazer DM, Wilkins SJ, Anderson GJ. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut. 2004;53:655-60.
28. Roe MA, Collings R, Dainty JR, Swinkels DW, Fairweather-Tait SJ. Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men. Am J Clin Nutr. 2009; 89:1088-91.
29. Zimmermann MB, Troesch B, Biebinger R, Egli I, Zeder C, Hurrell RF. Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin. Am J Clin Nutr. 2009;90:1280-7.
30. Gambling L, Czopek A, Andersen HS, Holtrop G, Srai SK, Krejpcio Z, McArdle HJ. Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1063-70.
31. Young MF, Pressman E, Foehr ML, McNanley T, Cooper E, Guillet R, Orlando M, McIntyre AW, Lafond J, O'Brien KO. Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents. Placenta. 2010;31:1010-4.
32. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N, Joory KD, Srai SK, McArdle HJ. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J. 2001;356:883-9.
33. Georgieff MK, Berry SA, Wobken JD, Leibold EA. Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. Placenta. 1999;20:87-93.
34. Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE, Georgieff MK. Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand. Am J Physiol. 1994;267: E507-14.
35. Rao R, Georgieff MK. Iron in fetal and neonatal nutrition. Semin Fetal Neonatal Med. 2007;12:54-63.
36. West AR, Oates PS. Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol. 2008;14:4101-10.
37. Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A, Abkowitz JL. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem. 2010;285:28874-82.
38. Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, Domenico I, Vaughn MB, Kaplan J, et al. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008;319:825-8.
39. Taketani S, Kohno H, Tokunaga R. Cell surface receptor for hemopexin in human leukemia HL60 cells. Specific binding, affinity labeling, and fate of heme. J Biol Chem. 1987;262:4639-43.
40. Jaacks LM, YoungMF, Essley BV, McNanley TJ, Cooper EM, Pressman EK, McIntyre AW, Orlando MS, Abkowitz JL, Guillet R, et al. Placental expression of the heme transporter, feline leukemia virus subgroup c receptor, is related to maternal iron status in pregnant adolescents. J Nutr. 2011;141:1267-72.
41. Brown EB, Hwang YF, Nicol S, Ternberg J. Absorption of radiationlabeled hemoglobin by dogs. J Lab Clin Med. 1968;72:58-64.
42. Turnbull A, Cleton F, Finch CA. Iron absorption. IV. The absorption of hemoglobin iron. J Clin Invest. 1962;41:1897-907.
43. Viteri FE. The consequences of iron deficiency and anemia in pregnancy. In: Allen L, King J, Lonnerdahl B, editors. Nutrient regulation during pregnancy, lactation and growth. New York: Plenum Press; 1994.
44. Mena NP, Esparza A, Tapia V, Valdes P, Nunez MT. Hepcidin inhibits apical iron uptake in intestinal cells. Am J Physiol Gastrointest Liver Physiol. 2008;294:G192-8.
45. Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K, Sankilampi U. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol. 2010;85:345-52.
46. Chang SC, O'Brien KO, Nathanson MS, Mancini J, Witter FR. Hemoglobin concentrations influence birth outcomes in pregnant African-American adolescents. J Nutr. 2003;133:2348-55.