Influences of yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats

Experimental Animals

Volumn 65, Issue 4, 2016, Pages 353-361

  Tamano, Haruna ^a   Yusuke, Enya ^a   Ide, Kazuki ^a   Takeda, Atsushi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Aggressive behavior; Social isolation; Yokukansan; Yokukansankachimpihange; Zinc deficiency

Indexed keywords

CALCIUM; DIMETHYL ETHER; GEISSOSCHIZINE; GLYCYRRHETINIC ACID; HERBACEOUS AGENT; UNCLASSIFIED DRUG; YOKUKANSANKACHIMPIHANGE; 18ALPHA-GLYCYRRHETINIC ACID; GEISSOSCHIZINE METHYLETHER; INDOLE ALKALOID; ZINC;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; EXOCYTOSIS; HIPPOCAMPAL MOSSY FIBER; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PINELLIA TUBER; PRESYNAPTIC MEMBRANE; RAT; RESIDENT-INTRUDER TEST; SATSUMA; SOCIAL ISOLATION; ZINC DEFICIENCY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DEFICIENCY; DRUG EFFECT; HIPPOCAMPUS; METABOLISM; WISTAR RAT;

AGGRESSION; ANIMALS; DRUGS, CHINESE HERBAL; EXOCYTOSIS; GLYCYRRHETINIC ACID; HIPPOCAMPUS; INDOLE ALKALOIDS; MALE; MICE; RATS; RATS, WISTAR; ZINC;

EID: 84994371783     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.16-0028     Document Type: Article

References (32)

1. Cerqueira, J.J., Pêgo, J.M., Taipa, R., Bessa, J.M., Almeida, O.F., and Sousa, N. 2005. Morphological correlates of corticosteroid- induced changes in prefrontal cortex-dependent behaviors. J. Neurosci. 25: 7792–7800. [Medline] [Cross- Ref]
2. Csernansky, J.G., Dong, H., Fagan, A.M., Wang, L., Xiong, C., Holtzman, D.M., and Morris, J.C. 2006. Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Am. J. Psychiatry 163: 2164–2169. [Medline] [CrossRef]
3. Davis, K.L., Davis, B.M., Greenwald, B.S., Mohs, R.C., Mathé, A.A., Johns, C.A., and Horvath, T.B. 1986. Cortisol and Alzheimer’s disease, I: Basal studies. Am. J. Psychiatry 143: 300–305. [Medline] [CrossRef]
4. Dong, H. and Csernansky, J.G. 2009. Effects of stress and stress hormones on amyloid-beta protein and plaque deposition. J. Alzheimers Dis. 18: 459–469. [Medline]
5. Ikarashi, Y., Iizuka, S., Imamura, S., Yamaguchi, T., Sekiguchi, K., Kanno, H., Kawakami, Z., Yuzurihara, M., Kase, Y., and Takeda, S. 2009. Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol. Pharm. Bull. 32: 1701–1709. [Medline] [CrossRef]
6. Imamura, S., Tabuchi, M., Kushida, H., Nishi, A., Kanno, H., Yamaguchi, T., Sekiguchi, K., Ikarashi, Y., and Kase, Y. 2011. The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan. Cell. Mol. Neurobiol. 31: 787–793. [Medline] [CrossRef]
7. Ito, A., Shin, N., Tsuchida, T., Okubo, T., and Norimoto, H. 2013. Antianxiety-like effects of Chimpi (dried citrus peels) in the elevated open-platform test. Molecules 18: 10014–10023. [Medline] [CrossRef]
8. Iwasaki, K., Satoh-Nakagawa, T., Maruyama, M., Monma, Y., Nemoto, M., Tomita, N., Tanji, H., Fujiwara, H., Seki, T., Fujii, M., Arai, H., and Sasaki, H. 2005. Arandomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J. Clin. Psychiatry 66: 248–252. [Medline] [CrossRef]
9. Kawakami, Z., Kanno, H., Ikarashi, Y., and Kase, Y. 2011. Yokukansan, a kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cells. J. Ethnopharmacol. 134: 74–81. [Medline] [CrossRef]
10. Kawanabe, T., Yoritaka, A., Shimura, H., Oizumi, H., Tanaka, S., and Hattori, N. 2010. Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. Prog. Neuropsychopharmacol. Biol. Psychiatry 34: 284–287. [Medline] [CrossRef]
11. Klingauf, J., Kavalali, E.T., and Tsien, R.W. 1998. Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature 394: 581–585. [Medline] [CrossRef]
12. Kung, F.C., Ishii, R., Liu, H.C., and Takeda, M. 2012. New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia. Clin. Interv. Aging 7: 393–396. [Medline]
13. Matsuda, Y., Kishi, T., Shibayama, H., and Iwata, N. 2013. Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and metaanalysis of randomized controlled trials. Hum. Psychopharmacol. 28: 80–86. [Medline] [CrossRef]
14. Mirakhur, A., Craig, D., Hart, D.J., McLlroy, S.P., and Passmore, A.P. 2004. Behavioural and psychological syndromes in Alzheimer’s disease. Int. J. Geriatr. Psychiatry 19: 1035–1039. [Medline] [CrossRef]
15. Mizoguchi, K., Kushida, H., Kanno, H., Igarashi, Y., Nishimura, H., Ikarashi, Y., and Kase, Y. 2014. Specific binding and characteristics of geissoschizine methyl ether, an indole alkaloid of Uncaria Hook, in the rat brain. J. Ethnopharmacol. 158:(Pt A): 264–270. [Medline] [CrossRef]
16. Mizoguchi, K., Kanno, H., Ikarashi, Y., and Kase, Y. 2014. Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain. PLoS One 9: e95760. [Medline] [CrossRef]
17. Monji, A., Takita, M., Samejima, T., Takaishi, T., Hashimoto, K., Matsunaga, H., Oda, M., Sumida, Y., Mizoguchi, Y., Kato, T., Horikawa, H., and Kanba, S. 2009. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer’s disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 33: 308–311. [Medline] [CrossRef]
18. Nagaratnam, N., Lewis-Jones, M., Scott, D., and Palazzi, L. 1998. Behavioral and psychiatric manifestations in dementia patients in a community: caregiver burden and outcome. Alzheimer Dis. Assoc. Disord. 12: 330–334. [Medline] [Cross- Ref]
19. Nishi, A., Yamaguchi, T., Sekiguchi, K., Imamura, S., Tabuchi, M., Kanno, H., Nakai, Y., Hashimoto, K., Ikarashi, Y., and Kase, Y. 2012. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin 1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience 207: 124–136. [Medline] [CrossRef]
20. Pan, Y.J., Wu, C.S., Gau, S.S., Chan, H.Y., and Banerjee, S. 2014. Antipsychotic discontinuation in patients with dementia: a systematic review and meta-analysis of published randomized controlled studies. Dement. Geriatr. Cogn. Disord. 37: 125–140. [Medline] [CrossRef]
21. Shinno, H., Inami, Y., Inagaki, T., Nakamura, Y., and Horiguchi, J. 2008. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. Prog. Neuropsychopharmacol. Biol. Psychiatry 32: 881–885. [Medline] [CrossRef]
22. Steele, C., Rovner, B., Chase, G.A., and Folstein, M. 1990. Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am. J. Psychiatry 147: 1049–1051. [Medline] [CrossRef]
23. Takeda, A. 2010. Insight into glutamate excitotoxicity from synaptic zinc homeostasis. Int. J. Alzheimers Dis. 2011: 491597. [Medline]
24. Takeda, A. and Tamano, H. 2009. Insight into zinc signaling from dietary zinc deficiency. Brain Res. Brain Res. Rev. 62: 33–44. [Medline] [CrossRef]
25. Takeda, A., Tamano, H., Kan, F., Hanajima, T., Yamada, K., and Oku, N. 2008. Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. Life Sci. 82: 909–914. [Medline] [CrossRef]
26. Takeda, A., Tamano, H., Itoh, H., and Oku, N. 2008. Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem. Int. 53: 230–235. [Medline] [CrossRef]
27. Takeda, S., Ishthara, K., Wakui, Y., Amagaya, S., Maruno, M., Akao, T., and Kobashi, K. 1996. Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis. J. Pharm. Pharmacol. 48: 902–905. [Medline] [CrossRef]
28. Takeuchi, H., Mizoguchi, H., Doi, Y., Jin, S., Noda, M., Liang, J., Li, H., Zhou, Y., Mori, R., Yasuoka, S., Li, E., Parajuli, B., Kawanokuchi, J., Sonobe, Y., Sato, J., Yamanaka, K., Sobue, G., Mizuno, T., and Suzumura, A. 2011. Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer’s disease. PLoS ONE 6: e21108. [Medline] [CrossRef]
29. Tamano, H., Kan, F., Oku, N., and Takeda, A. 2010. Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. Brain Res. Bull. 83: 351–355. [Medline] [CrossRef]
30. Tanji, H., Ootsuka, M., Matsui, T., Maruyama, M., Nemoto, M., and Tomita, N. 2005. Dementia caregivers’ burdens and use of public services. Geriatr. Gerontol. Int. 5: 94–98. [CrossRef]
31. Yamakuni, T., Nakajima, A., and Ohizumi, Y. 2008. Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods. Nippon Yakurigaku Zasshi 132: 155–159. [Medline] [CrossRef]
32. Zakharenko, S.S., Zablow, L., and Siegelbaum, S.A. 2001. Visualization of changes in presynaptic function during long-term synaptic plasticity. Nat. Neurosci. 4: 711–717. [Medline] [CrossRef]