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Volumn 90, Issue 3, 2016, Pages 493-501

A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis

Author keywords

autoimmunity; disease activity; immune complex; proteinuria; trial design

Indexed keywords

ABATACEPT; ALPHA INTERFERON; ANIFROLUMAB; AZATHIOPRINE; BELIMUMAB; CD11B ANTIGEN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KIDNEY INJURY MOLECULE 1; LAQUINIMOD; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLATE MOFETIL; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; ANTINUCLEAR ANTIBODY; BIOLOGICAL MARKER; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; MEMBRANE PROTEIN; NEPHRIN;

EID: 84994336868     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.05.017     Document Type: Review
Times cited : (82)

References (54)
  • 1
    • 84961872402 scopus 로고    scopus 로고
    • The frequency and outcome of lupus nephritis: results from an international inception cohort study
    • 1 Hanly, J.G., O'Keeffe, A.G., Su, L., et al. The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford) 55:2 (2016), 252–262.
    • (2016) Rheumatology (Oxford) , vol.55 , Issue.2 , pp. 252-262
    • Hanly, J.G.1    O'Keeffe, A.G.2    Su, L.3
  • 2
    • 34447098797 scopus 로고    scopus 로고
    • Multistep pathogenesis of autoimmune disease
    • 2 Goodnow, C.C., Multistep pathogenesis of autoimmune disease. Cell 130:1 (2007), 25–35.
    • (2007) Cell , vol.130 , Issue.1 , pp. 25-35
    • Goodnow, C.C.1
  • 3
    • 84884321720 scopus 로고    scopus 로고
    • The pathogenesis of lupus nephritis
    • 3 Lech, M., Anders, H.J., The pathogenesis of lupus nephritis. J Am Soc Nephrol 24:9 (2013), 1357–1366.
    • (2013) J Am Soc Nephrol , vol.24 , Issue.9 , pp. 1357-1366
    • Lech, M.1    Anders, H.J.2
  • 4
    • 84946481488 scopus 로고    scopus 로고
    • Immunogenetics of systemic lupus erythematosus: a comprehensive review
    • 4 Ghodke-Puranik, Y., Niewold, T.B., Immunogenetics of systemic lupus erythematosus: a comprehensive review. J Autoimmun 64 (2015), 125–136.
    • (2015) J Autoimmun , vol.64 , pp. 125-136
    • Ghodke-Puranik, Y.1    Niewold, T.B.2
  • 5
    • 74849122634 scopus 로고    scopus 로고
    • Complete complement deficiency in a large cohort of familial systemic lupus erythematosus
    • 5 Aggarwal, R., Sestak, A.L., D'Sousa, A., et al. Complete complement deficiency in a large cohort of familial systemic lupus erythematosus. Lupus 19:1 (2010), 52–57.
    • (2010) Lupus , vol.19 , Issue.1 , pp. 52-57
    • Aggarwal, R.1    Sestak, A.L.2    D'Sousa, A.3
  • 6
    • 84933279572 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome and the type I interferonopathies
    • 6 Crow, Y.J., Manel, N., Aicardi-Goutieres syndrome and the type I interferonopathies. Nat Rev Immunol 15:7 (2015), 429–440.
    • (2015) Nat Rev Immunol , vol.15 , Issue.7 , pp. 429-440
    • Crow, Y.J.1    Manel, N.2
  • 7
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • 7 Rahman, A., Isenberg, D.A., Systemic lupus erythematosus. N Engl J Med 358:9 (2008), 929–939.
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 8
    • 79952452617 scopus 로고    scopus 로고
    • Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
    • 8 Hiepe, F., Dörner, T., Hauser, A.E., et al. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7:3 (2011), 170–178.
    • (2011) Nat Rev Rheumatol , vol.7 , Issue.3 , pp. 170-178
    • Hiepe, F.1    Dörner, T.2    Hauser, A.E.3
  • 9
    • 84913582710 scopus 로고    scopus 로고
    • B cell epitope spreading: mechanisms and contribution to autoimmune diseases
    • 9 Cornaby, C., Gibbons, L., Mayhew, V., et al. B cell epitope spreading: mechanisms and contribution to autoimmune diseases. Immunol Lett 163:1 (2015), 56–68.
    • (2015) Immunol Lett , vol.163 , Issue.1 , pp. 56-68
    • Cornaby, C.1    Gibbons, L.2    Mayhew, V.3
  • 10
    • 70749096596 scopus 로고    scopus 로고
    • Pseudoviral immunity - a novel concept for lupus
    • 10 Anders, H.J., Pseudoviral immunity - a novel concept for lupus. Trends Mol Med 15:12 (2009), 553–561.
    • (2009) Trends Mol Med , vol.15 , Issue.12 , pp. 553-561
    • Anders, H.J.1
  • 11
    • 33144458473 scopus 로고    scopus 로고
    • G-rich DNA suppresses systemic lupus
    • 11 Patole, P.S., Zecher, D., Pawar, R.D., et al. G-rich DNA suppresses systemic lupus. J Am Soc Nephrol 16:11 (2005), 3273–3280.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.11 , pp. 3273-3280
    • Patole, P.S.1    Zecher, D.2    Pawar, R.D.3
  • 12
    • 34249915031 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    • 12 Pawar, R.D., Ramanjaneyulu, A., Kulkarni, O.P., et al. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 18:6 (2007), 1721–1731.
    • (2007) J Am Soc Nephrol , vol.18 , Issue.6 , pp. 1721-1731
    • Pawar, R.D.1    Ramanjaneyulu, A.2    Kulkarni, O.P.3
  • 13
    • 84857788719 scopus 로고    scopus 로고
    • A novel pathogenetic concept-antiviral immunity in lupus nephritis
    • 13 Migliorini, A., Anders, H.J., A novel pathogenetic concept-antiviral immunity in lupus nephritis. Nat Rev Nephrol 8:3 (2012), 183–189.
    • (2012) Nat Rev Nephrol , vol.8 , Issue.3 , pp. 183-189
    • Migliorini, A.1    Anders, H.J.2
  • 14
    • 84923869887 scopus 로고    scopus 로고
    • Lupus nephritis susceptibility loci in women with systemic lupus erythematosus
    • 14 Chung, S.A., Brown, E.E., Williams, A.H., et al. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol 25:12 (2014), 2859–2870.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.12 , pp. 2859-2870
    • Chung, S.A.1    Brown, E.E.2    Williams, A.H.3
  • 15
    • 84905908611 scopus 로고    scopus 로고
    • Immunopathology of lupus nephritis
    • 15 Anders, H.J., Fogo, A.B., Immunopathology of lupus nephritis. Semin Immunopathol 36:4 (2014), 443–459.
    • (2014) Semin Immunopathol , vol.36 , Issue.4 , pp. 443-459
    • Anders, H.J.1    Fogo, A.B.2
  • 16
    • 84893680312 scopus 로고    scopus 로고
    • End-stage renal disease in African Americans with lupus nephritis is associated with APOL1
    • 16 Freedman, B.I., Langefeld, C.D., Andringa, K.K., et al. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol 66:2 (2014), 390–396.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.2 , pp. 390-396
    • Freedman, B.I.1    Langefeld, C.D.2    Andringa, K.K.3
  • 17
    • 79251584335 scopus 로고    scopus 로고
    • In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis
    • 17 Chang, A., Henderson, S.G., Brandt, D., et al. In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol 186:3 (2011), 1849–1860.
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1849-1860
    • Chang, A.1    Henderson, S.G.2    Brandt, D.3
  • 18
    • 55249100762 scopus 로고    scopus 로고
    • The role of innate immunity in autoimmune tissue injury
    • 18 Allam, R., Anders, H.J., The role of innate immunity in autoimmune tissue injury. Curr Opin Rheumatol 20:5 (2008), 538–544.
    • (2008) Curr Opin Rheumatol , vol.20 , Issue.5 , pp. 538-544
    • Allam, R.1    Anders, H.J.2
  • 19
    • 84886794929 scopus 로고    scopus 로고
    • The immune system and kidney disease: basic concepts and clinical implications
    • 19 Kurts, C., Panzer, U., Anders, H.-J., et al. The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol 13:10 (2013), 738–753.
    • (2013) Nat Rev Immunol , vol.13 , Issue.10 , pp. 738-753
    • Kurts, C.1    Panzer, U.2    Anders, H.-J.3
  • 20
    • 0942265440 scopus 로고    scopus 로고
    • The classification of glomerulonephritis in systemic lupus erythematosus revisited
    • 20 Weening, J.J., D'Agati, V.D., Schwartz, M.M., et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 15:2 (2004), 241–250.
    • (2004) J Am Soc Nephrol , vol.15 , Issue.2 , pp. 241-250
    • Weening, J.J.1    D'Agati, V.D.2    Schwartz, M.M.3
  • 21
    • 84874577154 scopus 로고    scopus 로고
    • Kidney disease in lupus is not always 'lupus nephritis'
    • 21 Anders, H.J., Weening, J.J., Kidney disease in lupus is not always 'lupus nephritis'. Arthritis Res Ther, 15(2), 2013, 108.
    • (2013) Arthritis Res Ther , vol.15 , Issue.2 , pp. 108
    • Anders, H.J.1    Weening, J.J.2
  • 22
    • 84872140900 scopus 로고    scopus 로고
    • The spectrum of renal thrombotic microangiopathy in lupus nephritis
    • 22 Song, D., Wu, L.H., Wang, F.M., et al. The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther, 15(1), 2013, R12.
    • (2013) Arthritis Res Ther , vol.15 , Issue.1 , pp. R12
    • Song, D.1    Wu, L.H.2    Wang, F.M.3
  • 24
    • 84959053835 scopus 로고    scopus 로고
    • Exploring the genetic basis of early-onset chronic kidney disease
    • 24 Vivante, A., Hildebrandt, F., Exploring the genetic basis of early-onset chronic kidney disease. Nat Rev Nephrol 12:3 (2016), 133–146.
    • (2016) Nat Rev Nephrol , vol.12 , Issue.3 , pp. 133-146
    • Vivante, A.1    Hildebrandt, F.2
  • 25
    • 84955324880 scopus 로고    scopus 로고
    • Hurdles to the introduction of new therapies for immune-mediated kidney diseases
    • 25 Anders, H.J., Jayne, D.R., Rovin, B.H., Hurdles to the introduction of new therapies for immune-mediated kidney diseases. Nat Rev Nephrol 12:4 (2016), 205–216.
    • (2016) Nat Rev Nephrol , vol.12 , Issue.4 , pp. 205-216
    • Anders, H.J.1    Jayne, D.R.2    Rovin, B.H.3
  • 26
    • 84961655624 scopus 로고    scopus 로고
    • Histologic versus clinical remission in proliferative lupus nephritis
    • [e-pub ahead of print] pii: gfv296, accessed May 29, 2016
    • 26 Malvar, A., Pirruccio, P., Lococo, B., et al. Histologic versus clinical remission in proliferative lupus nephritis. [e-pub ahead of print] Nephrol Dial Transplant, 2015;Aug 6 pii: gfv296, accessed May 29, 2016.
    • (2015) Nephrol Dial Transplant
    • Malvar, A.1    Pirruccio, P.2    Lococo, B.3
  • 27
    • 84927770358 scopus 로고    scopus 로고
    • Role of early repeated renal biopsies in lupus nephritis
    • 27 Zickert, A., Sundelin, B., Svenungsson, E., Gunnarsson, I., Role of early repeated renal biopsies in lupus nephritis. Lupus Sci Med, 1(1), 2014, e000018.
    • (2014) Lupus Sci Med , vol.1 , Issue.1 , pp. e000018
    • Zickert, A.1    Sundelin, B.2    Svenungsson, E.3    Gunnarsson, I.4
  • 28
    • 84903539377 scopus 로고    scopus 로고
    • The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients
    • 28 Alvarado, A.S., Malvar, A., Lococo, B., et al. The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients. Lupus 23:8 (2014), 840–847.
    • (2014) Lupus , vol.23 , Issue.8 , pp. 840-847
    • Alvarado, A.S.1    Malvar, A.2    Lococo, B.3
  • 29
    • 84928543138 scopus 로고    scopus 로고
    • The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers
    • 29 Kopetschke, K., Klocke, J., Grießbach, A.-S., et al. The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers. Arthritis Res Ther, 17, 2015, 94.
    • (2015) Arthritis Res Ther , vol.17 , pp. 94
    • Kopetschke, K.1    Klocke, J.2    Grießbach, A.-S.3
  • 30
    • 84864454184 scopus 로고    scopus 로고
    • Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis
    • 30 Brunner, H.I., Bennett, M.R., Mina, R., et al. Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum 64:8 (2012), 2687–2697.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2687-2697
    • Brunner, H.I.1    Bennett, M.R.2    Mina, R.3
  • 32
    • 84859308909 scopus 로고    scopus 로고
    • Strategy for second kidney biopsy in patients with lupus nephritis
    • 32 Alsuwaida, A., Husain, S., Alghonaim, M., et al. Strategy for second kidney biopsy in patients with lupus nephritis. Nephrol Dial Transplant 27 (2012), 1472–1478.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1472-1478
    • Alsuwaida, A.1    Husain, S.2    Alghonaim, M.3
  • 33
    • 84858982530 scopus 로고    scopus 로고
    • KDIGO Clinical Practice Guidelines for Glomerulonephritis
    • 33 Kidney Disease Improving Global Outcomes (KDIGO). KDIGO Clinical Practice Guidelines for Glomerulonephritis. Kidney Int(suppl 2), 2012, 139–274.
    • (2012) Kidney Int , pp. 139-274
  • 34
    • 84867907436 scopus 로고    scopus 로고
    • The kidney in systemic lupus erythematosus
    • R.G. Lahita Academic Press London
    • 34 Rovin, B.H., Stillman, I.E., The kidney in systemic lupus erythematosus. Lahita, R.G., (eds.) Systemic Lupus Erythematosus, 2011, Academic Press, London, 769–814.
    • (2011) Systemic Lupus Erythematosus , pp. 769-814
    • Rovin, B.H.1    Stillman, I.E.2
  • 35
    • 84868126198 scopus 로고    scopus 로고
    • Abatacept for lupus nephritis: alternative definitions of complete response support conflicting conclusions
    • 35 Wofsy, D., Hillson, J.L., Diamond, B., Abatacept for lupus nephritis: alternative definitions of complete response support conflicting conclusions. Arthritis Rheum 64:11 (2012), 3660–3665.
    • (2012) Arthritis Rheum , vol.64 , Issue.11 , pp. 3660-3665
    • Wofsy, D.1    Hillson, J.L.2    Diamond, B.3
  • 36
    • 84896274377 scopus 로고    scopus 로고
    • Efficacy and safety of abatacept in lupus nephritis: a twelve-month randomized, double-blind study
    • 36 Furie, R., Nicholls, K., Cheng, T.T., et al. Efficacy and safety of abatacept in lupus nephritis: a twelve-month randomized, double-blind study. Arthritis Rheumatol 66 (2014), 379–389.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 379-389
    • Furie, R.1    Nicholls, K.2    Cheng, T.T.3
  • 37
    • 84928605460 scopus 로고    scopus 로고
    • Predictors of long-term renal outcome in lupus nephritis trials: lessons learned from the Euro-Lupus Nephritis cohort
    • 37 Dall'Era, M., Cisternas, M.G., Smilek, D.E., et al. Predictors of long-term renal outcome in lupus nephritis trials: lessons learned from the Euro-Lupus Nephritis cohort. Arthritis Rheumatol 67:5 (2015), 1305–1313.
    • (2015) Arthritis Rheumatol , vol.67 , Issue.5 , pp. 1305-1313
    • Dall'Era, M.1    Cisternas, M.G.2    Smilek, D.E.3
  • 38
    • 84949191564 scopus 로고    scopus 로고
    • A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN Nephritis Trial
    • 38 Tamirou, F., Lauwerys, B.R., Dall'Era, M., et al. A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN Nephritis Trial. Lupus Sci Med, 2(1), 2015, e000123.
    • (2015) Lupus Sci Med , vol.2 , Issue.1 , pp. e000123
    • Tamirou, F.1    Lauwerys, B.R.2    Dall'Era, M.3
  • 39
    • 0036673864 scopus 로고    scopus 로고
    • Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide
    • 39 Houssiau, F.A., Vasconcelos, C., D'Cruz, D., et al. Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:8 (2002), 2121–2131.
    • (2002) Arthritis Rheum , vol.46 , Issue.8 , pp. 2121-2131
    • Houssiau, F.A.1    Vasconcelos, C.2    D'Cruz, D.3
  • 40
    • 84897112805 scopus 로고    scopus 로고
    • Lupus nephritis: the evolving role of novel therapeutics
    • 40 Rovin, B.H., Parikh, S.V., Lupus nephritis: the evolving role of novel therapeutics. Am J Kidney Dis 63:4 (2014), 677–690.
    • (2014) Am J Kidney Dis , vol.63 , Issue.4 , pp. 677-690
    • Rovin, B.H.1    Parikh, S.V.2
  • 41
    • 84885018204 scopus 로고    scopus 로고
    • Lupus nephritis and end-stage kidney disease
    • 41 Maroz, N., Segal, M.S., Lupus nephritis and end-stage kidney disease. Am J Med Sci 346:4 (2013), 319–323.
    • (2013) Am J Med Sci , vol.346 , Issue.4 , pp. 319-323
    • Maroz, N.1    Segal, M.S.2
  • 43
    • 84896289833 scopus 로고    scopus 로고
    • Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells
    • 43 Lourenco, E.V., Wong, M., Hahn, B.C., et al. Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells. Arthritis Rheumatol 66 (2014), 674–685.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 674-685
    • Lourenco, E.V.1    Wong, M.2    Hahn, B.C.3
  • 44
    • 84961649498 scopus 로고    scopus 로고
    • The Pharmacokinetics of Laquinimod and Mycophenolate Mofetil during Treatment of Active Lupus Nephritis
    • American Society of Nephrology Annual Meeting Atlanta
    • 44 Jayne, D., Appel, G.B., Chan, D.T.M., et al. The Pharmacokinetics of Laquinimod and Mycophenolate Mofetil during Treatment of Active Lupus Nephritis. 2013, American Society of Nephrology Annual Meeting, Atlanta.
    • (2013)
    • Jayne, D.1    Appel, G.B.2    Chan, D.T.M.3
  • 45
    • 84867398973 scopus 로고    scopus 로고
    • Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials
    • 45 Manzi, S., Sánchez-Guerrero, J., Merrill, J.T., et al. Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials. Ann Rheum Dis 71:11 (2012), 1833–1838.
    • (2012) Ann Rheum Dis , vol.71 , Issue.11 , pp. 1833-1838
    • Manzi, S.1    Sánchez-Guerrero, J.2    Merrill, J.T.3
  • 46
    • 84871574493 scopus 로고    scopus 로고
    • Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE
    • 46 Dooley, M.A., Houssiau, F., Aranow, C., et al. Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE. Lupus 22:1 (2013), 63–72.
    • (2013) Lupus , vol.22 , Issue.1 , pp. 63-72
    • Dooley, M.A.1    Houssiau, F.2    Aranow, C.3
  • 47
    • 84924812141 scopus 로고    scopus 로고
    • Treatment of lupus nephritis with abatacept: the abatacept and cyclophosphamide combination efficacy and safety study
    • 47 Group AT. Treatment of lupus nephritis with abatacept: the abatacept and cyclophosphamide combination efficacy and safety study. Arthritis Rheumatol 66:11 (2014), 3096–3104.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.11 , pp. 3096-3104
  • 48
    • 84955575843 scopus 로고    scopus 로고
    • Anifrolumab, an anti-interferon alpha receptor monoclonal antibody, in moderate to severe systemic lupus erythematosus
    • [abstract]
    • 48 Furie, R., Merrill, J., Werth, V., et al. Anifrolumab, an anti-interferon alpha receptor monoclonal antibody, in moderate to severe systemic lupus erythematosus. Am Coll Rheumatol, 67(suppl 10), 2015 [abstract].
    • (2015) Am Coll Rheumatol , vol.67
    • Furie, R.1    Merrill, J.2    Werth, V.3
  • 49
    • 84856153814 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture
    • 49 Hainz, N., Thomas, S., Neubert, K., et al. The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture. Nephron Exp Nephrol 120:2 (2012), e47–e58.
    • (2012) Nephron Exp Nephrol , vol.120 , Issue.2 , pp. e47-e58
    • Hainz, N.1    Thomas, S.2    Neubert, K.3
  • 50
    • 46749088320 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    • 50 Neubert, K., Meister, S., Moser, K., et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14:7 (2008), 748–755.
    • (2008) Nat Med , vol.14 , Issue.7 , pp. 748-755
    • Neubert, K.1    Meister, S.2    Moser, K.3
  • 51
    • 84856103470 scopus 로고    scopus 로고
    • Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE
    • 51 Seavey, M.M., Lu, L.D., Stump, K.L., et al. Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE. Int Immunopharmacol 12:1 (2012), 257–270.
    • (2012) Int Immunopharmacol , vol.12 , Issue.1 , pp. 257-270
    • Seavey, M.M.1    Lu, L.D.2    Stump, K.L.3
  • 52
    • 0026039559 scopus 로고
    • The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass
    • 52 Jansen, N.J., van Oeveren, W., van Vliet, M., et al. The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass. Eur J Cardiothorac Surg 5:4 (1991), 211–217.
    • (1991) Eur J Cardiothorac Surg , vol.5 , Issue.4 , pp. 211-217
    • Jansen, N.J.1    van Oeveren, W.2    van Vliet, M.3
  • 53
    • 84907424321 scopus 로고    scopus 로고
    • Protocol renal biopsy in patients with lupus nephritis: a single center experience
    • 53 Singh, A., Ghosh, R., Kaur, P., et al. Protocol renal biopsy in patients with lupus nephritis: a single center experience. Saudi J Kidney Dis Transpl 25:4 (2014), 801–807.
    • (2014) Saudi J Kidney Dis Transpl , vol.25 , Issue.4 , pp. 801-807
    • Singh, A.1    Ghosh, R.2    Kaur, P.3
  • 54
    • 84954059408 scopus 로고    scopus 로고
    • Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine
    • 54 Anders, H.J., Weidenbusch, M., Rovin, B., Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine. Clin Kidney J 8:5 (2015), 492–502.
    • (2015) Clin Kidney J , vol.8 , Issue.5 , pp. 492-502
    • Anders, H.J.1    Weidenbusch, M.2    Rovin, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.