Anti-inflammatory protection afforded by cyanidin-3-glucoside and resveratrol in human intestinal cells via Nrf2 and PPAR-γ: Comparison with 5-aminosalicylic acid

Chemico-Biological Interactions

Volumn 260, Issue , 2016, Pages 102-109

  Serra, Diana ^a,b   Almeida, Leonor M ^a,b   Dinis, Teresa C P ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Cyanidin 3 glucoside; Inflammation; Intestinal epithelial cells; Nrf2 activation; PPAR pathway; Resveratrol

Indexed keywords

CYANIDIN 3 GLUCOSIDE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEME OXYGENASE 1; MESALAZINE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; RESVERATROL; TRANSCRIPTION FACTOR NRF2; ANTHOCYANIN; ANTIINFLAMMATORY AGENT; CYANIDIN 3-O-GLUCOSIDE; CYTOKINE; GLUCOSIDE; NFE2L2 PROTEIN, HUMAN; PROTEIN SUBUNIT; STILBENE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CELL NUCLEUS; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENTERITIS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HT 29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE CELL; OXIDATIVE STRESS; PROTEIN FUNCTION; CATALYSIS; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENETICS; HT-29 CELL LINE; INTESTINE; INTRACELLULAR SPACE; METABOLISM; PROTEIN SUBUNIT;

ANTHOCYANINS; ANTI-INFLAMMATORY AGENTS; CATALYSIS; CELL NUCLEUS; CYTOKINES; CYTOPROTECTION; GENE EXPRESSION REGULATION; GLUCOSIDES; GLUTATHIONE DISULFIDE; HEME OXYGENASE-1; HT29 CELLS; HUMANS; INTESTINES; INTRACELLULAR SPACE; MESALAMINE; NF-E2-RELATED FACTOR 2; PPAR GAMMA; PROTEIN SUBUNITS; RNA, MESSENGER; STILBENES;

EID: 84994291489     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2016.11.003     Document Type: Article

References (33)

1. [1] Xavier, R.J., Podolsky, D.K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 448 (2007), 427–434.
2. [2] Biasi, F., Leonarduzzi, G., Oteiza, P.I., Poli, G., Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid. Redox Signal 19 (2013), 1711–1747.
3. [3] Maynard, C.L., Elson, C.O., Hatton, R.D., Weaver, C.T., Reciprocal interactions of the intestinal microbiota and immune system. Nature 489 (2012), 231–241.
4. [4] Schneider, M.J., Phytochemicals for the treatment of inflammatory bowel diseases. Phytochem. Rev. 13 (2014), 629–642.
5. [5] Biasi, F., Astegiano, M., Maina, M., Leonarduzzi, G., Poli, G., Polyphenol supplementation as a complementary medicinal approach to treating inflammatory bowel disease. Curr. Med. Chem. 18 (2011), 4851–4865.
6. [6] Munoz-Gonzalez, I., Espinosa-Martos, I., Rodriguez, J.M., Jimenez-Giron, A., Martin-Alvarez, P.J., et al. Moderate consumption of red wine can modulate human intestinal inflammatory response. J. Agric. Food Chem. 62 (2014), 10567–10575.
7. [7] Manach, C., Scalbert, A., Morand, C., Remesy, C., Jimenez, L., Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 79 (2004), 727–747.
8. [8] Romier, B., Schneider, Y.J., Larondelle, Y., During, A., Dietary polyphenols can modulate the intestinal inflammatory response. Nutr. Rev. 67 (2009), 363–378.
9. [9] Biasi, F., Deiana, M., Guina, T., Gamba, P., Leonarduzzi, G., et al. Wine consumption and intestinal redox homeostasis. Redox Biol. 2 (2014), 795–802.
10. [10] Williamson, G., Manach, C., Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr. 81 (2005), 243S–255S.
11. [11] Kaspar, J.W., Niture, S.K., Jaiswal, A.K., Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic. Biol. Med. 47 (2009), 1304–1309.
12. [12] Kim, J., Cha, Y.N., Surh, Y.J., A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 690 (2010), 12–23.
13. [13] Dubuquoy, L., Rousseaux, C., Thuru, X., Peyrin-Biroulet, L., Romano, O., et al. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 55 (2006), 1341–1349.
14. [14] Polvani, S., Tarocchi, M., Galli, A., PPARgamma and oxidative stress: con(beta) catenating NRF2 and FOXO. PPAR Res., 2012, 2012, 641087.
15. [15] Serra, D., Paixao, J., Nunes, C., Dinis, T.C., Almeida, L.M., Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: comparison with 5-aminosalicylic acid. PLoS One, 8, 2013, e73001.
16. [16] Serra, D., Rufino, A.T., Mendes, A.F., Almeida, L.M., Dinis, T.C., Resveratrol modulates cytokine-induced Jak/STAT activation more efficiently than 5-aminosalicylic acid: an in vitro approach. PLoS One, 9, 2014, e109048.
17. [17] Williams, C., Panaccione, R., Ghosh, S., Rioux, K., Optimizing clinical use of mesalazine (5-aminosalicylic acid) in inflammatory bowel disease. Ther. Adv. Gastroenterol. 4 (2011), 237–248.
18. [18] Hissin, P.J., Hilf, R., A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1976), 214–226.
19. [19] Halliwell, B., Whiteman, M., Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. Br. J. Pharmacol. 142 (2004), 231–255.
20. [20] Khor, T.O., Huang, M.T., Kwon, K.H., Chan, J.Y., Reddy, B.S., et al. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res. 66 (2006), 11580–11584.
21. [21] Rushworth, S.A., Shah, S., MacEwan, D.J., TNF mediates the sustained activation of Nrf2 in human monocytes. J. Immunol. 187 (2011), 702–707.
22. [22] Speciale, A., Anwar, S., Canali, R., Chirafisi, J., Saija, A., et al. Cyanidin-3-O-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway. Mol. Nutr. Food Res. 57 (2013), 1979–1987.
23. [23] Zhu, X., Fan, W.G., Li, D.P., Kung, H., Lin, M.C., Heme oxygenase-1 system and gastrointestinal inflammation: a short review. World J. Gastroenterol. 17 (2011), 4283–4288.
24. [24] Vijayan, V., Mueller, S., Baumgart-Vogt, E., Immenschuh, S., Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract. World J. Gastroenterol. 16 (2010), 3112–3119.
25. [25] Wakabayashi, N., Slocum, S.L., Skoko, J.J., Shin, S., Kensler, T.W., When NRF2 talks, who's listening?. Antioxid. Redox Signal 13 (2010), 1649–1663.
26. [26] Lu, S.C., Glutathione synthesis. Biochim. Biophys. Acta 1830 (2013), 3143–3153.
27. [27] Wu, G., Fang, Y.Z., Yang, S., Lupton, J.R., Turner, N.D., Glutathione metabolism and its implications for health. J. Nutr. 134 (2004), 489–492.
28. [28] Oz, H.S., Chen, T., de Villiers, W.J., Green tea polyphenols and sulfasalazine have parallel anti-inflammatory properties in colitis models. Front. Immunol., 4, 2013, 132.
29. [29] Annese, V., Rogai, F., Settesoldi, A., Bagnoli, S., PPARgamma in inflammatory bowel disease. PPAR Res., 2012, 2012, 620839.
30. [30] Varga, T., Czimmerer, Z., Nagy, L., PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim. Biophys. Acta 1812 (2011), 1007–1022.
31. [31] Ricote, M., Glass, C.K., PPARs and molecular mechanisms of transrepression. Biochim. Biophys. Acta 1771 (2007), 926–935.
32. [32] Desreumaux, P., Ghosh, S., Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence. Aliment. Pharmacol. Ther. 24:Suppl 1 (2006), 2–9.
33. [33] Delerive, P., Fruchart, J.C., Staels, B., Peroxisome proliferator-activated receptors in inflammation control. J. Endocrinol. 169 (2001), 453–459.