Pretransplantation Donor–Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation

American Journal of Transplantation

Volumn 17, Issue 1, 2017, Pages 161-172

  Wunderink, H F ^a   van der Meijden, E ^a   van der Blij de Brouwer, C S ^a   Mallat, M J K ^a   Haasnoot, G W ^a   van Zwet, E W ^a   Claas, E C J ^a   de Fijter, J W ^a   Kroes, A C M ^a   Arnold, F ^b   Touze A ^b   Claas, F H J ^a   Rotmans, J I ^a   Feltkamp, M C W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UR1282   (France)

Author keywords

basic (laboratory) research science; BK polyomavirus; clinical research practice; donors and donation: donor derived infections; infection and infectious agents; infectious disease; kidney disease: infectious; kidney transplantation; kidney transplantation nephrology; nephropathy; risk assessment risk stratification; risk factors; serology; seroreactivity; viral: BK JC polyoma; viremia

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; PREDNISOLONE; TACROLIMUS;

ADULT; ARTICLE; BK VIRUS; BK VIRUS INFECTION; BLOOD COMPATIBILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DOSE REDUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GRAFT RECIPIENT; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ORGAN DONOR; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEROPREVALENCE; UNRELATED DONORS; VIRUS LOAD; VIRUS REPLICATION; BLOOD; EPIDEMIOLOGY; GLOMERULUS FILTRATION RATE; IMMUNOLOGY; KIDNEY FUNCTION TEST; LIVING DONOR; NETHERLANDS; PATHOGENICITY; POLYOMAVIRUS INFECTION; PROGNOSIS; RISK FACTOR; VIREMIA; VIROLOGY; VIRUS INFECTION;

BK VIRUS; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; NETHERLANDS; POLYOMAVIRUS INFECTIONS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; TRANSPLANT RECIPIENTS; TUMOR VIRUS INFECTIONS; VIREMIA;

EID: 84994165589     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13880     Document Type: Article

References (38)

1. Rinaldo CH, Tylden GD, Sharma BN. The human polyomavirus BK (BKPyV): Virological background and clinical implications. APMIS 2013; 121: 728–745.
2. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3: 611–623.
3. Kean JM, Rao S, Wang M, Garcea RL. Seroepidemiology of human polyomaviruses. PLoS Pathog 2009; 5: e1000363.
4. van der Meijden E, Bialasiewicz S, Rockett RJ, Tozer SJ, Sloots TP, Feltkamp MC. Different serologic behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 polyomaviruses found on the skin. PLoS ONE 2013; 8: e81078.
5. Boldorini R, Veggiani C, Barco D, Monga G. Kidney and urinary tract polyomavirus infection and distribution: Molecular biology investigation of 10 consecutive autopsies. Arch Pathol Lab Med 2005; 129: 69–73.
6. Chesters PM, Heritage J, McCance DJ. Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983; 147: 676–684.
7. Egli A, Infanti L, Dumoulin A, et al. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis 2009; 199: 837–846.
8. Kling CL, Wright AT, Katz SE, et al. Dynamics of urinary polyomavirus shedding in healthy adult women. J Med Virol 2012; 84: 1459–1463.
9. Zhong S, Zheng HY, Suzuki M, et al. Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals. J Clin Microbiol 2007; 45: 193–198.
10. Hirsch HH, Drachenberg CB, Steiger J, Ramos E. Polyomavirus-associated nephropathy in renal transplantation: Critical issues of screening and management. Adv Exp Med Biol 2006; 577: 160–173.
11. Hardinger KL, Koch MJ, Bohl DJ, Storch GA, Brennan DC. BK-virus and the impact of pre-emptive immunosuppression reduction: 5-year results. Am J Transplant 2010; 10: 407–415.
12. Sood P, Senanayake S, Sujeet K, et al. Management and outcome of BK viremia in renal transplant recipients: A prospective single-center study. Transplantation 2012; 94: 814–821.
13. Borni-Duval C, Caillard S, Olagne J, et al. Risk factors for BK virus infection in the era of therapeutic drug monitoring. Transplantation 2013; 95: 1498–1505.
14. Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002; 347: 488–496.
15. Huang G, Zhang L, Liang X, et al. Risk factors for BK virus infection and BK virus-associated nephropathy under the impact of intensive monitoring and pre-emptive immunosuppression reduction. Transplant Proc 2014; 46: 3448–3454.
16. Elfadawy N, Flechner SM, Schold JD, et al. Transient versus persistent BK viremia and long-term outcomes after kidney and kidney-pancreas transplantation. Clin J Am Soc Nephrol 2014; 9: 553–561.
17. Hirsch HH, Brennan DC, Drachenberg CB, et al. Polyomavirus-associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation 2005; 79: 1277–1286.
18. Hirsch HH, Yakhontova K, Lu M, Manzetti J. BK Polyomavirus replication in renal tubular epithelial cells is inhibited by sirolimus, but activated by tacrolimus through a pathway involving FKBP-12. Am J Transplant 2015; 16: 821–832.
19. Bohl DL, Storch GA, Ryschkewitsch C, et al. Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant 2005; 5: 2213–2221.
20. Hassig A, Roos M, Etter A, Bossart W, Muller N, Schiesser M, et al. Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. Transpl Infect Dis 2014; 16: 44–54.
21. Bohl DL, Brennan DC, Ryschkewitsch C, Gaudreault-Keener M, Major EO, Storch GA. BK virus antibody titers and intensity of infections after renal transplantation. J Clin Virol 2008; 43: 184–189.
22. Sood P, Senanayake S, Sujeet K, et al. Donor and recipient BKV-specific IgG antibody and posttransplantation BKV infection: A prospective single-center study. Transplantation 2013; 95: 896–902.
23. Schmitt C, Raggub L, Linnenweber-Held S, Adams O, Schwarz A, Heim A. Donor origin of BKV replication after kidney transplantation. J Clin Virol 2014; 59: 120–125.
24. Hariharan S, Cohen EP, Vasudev B, et al. BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis. Am J Transplant 2015; 5: 2719–2724.
25. Randhawa P, Bohl D, Brennan D, et al. longitudinal analysis of levels of immunoglobulins against BK virus capsid proteins in kidney transplant recipients. Clin Vaccine Immunol 2008; 15: 1564–1571.
26. Niesters HG. Clinical virology in real time. J Clin Virol 2002; 25 (Suppl 3): S3–S12.
27. van der Meijden E, Wunderink HF, van der Blij-de Brouwer CS, et al. Human polyomavirus 9 infection in kidney transplant patients. Emerg Infect Dis 2014; 20: 991–999.
28. van der Meijden E, Kazem S, Burgers MM, et al. Seroprevalence of trichodysplasia spinulosa-associated polyomavirus. Emerg Infect Dis 2011; 17: 1355–1363.
29. Newton R, Ribeiro T, Casabonne D, et al. Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort. Br J Cancer 2005; 93: 1305–1306.
30. Touze A, Bousarghin L, Ster C, Combita AL, Roingeard P, Coursaget P. Gene transfer using human polyomavirus BK virus-like particles expressed in insect cells. J Gen Virol 2001; 82: 3005–3009.
31. Waterboer T, Sehr P, Michael KM, et al. Multiplex human papillomavirus serology based on in situ-purified glutathione s-transferase fusion proteins. Clin Chem 2005; 51: 1845–1853.
32. Parasuraman R, Abouljoud M, Jacobsen G, Reddy G, Koffron A, Venkat KK. Increasing trend in infection-related death-censored graft failure in renal transplantation. Transplantation 2011; 91: 94–99.
33. Atencio IA, Shadan FF, Zhou XJ, Vaziri ND, Villarreal LP. Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infections in response to cellular damage and regeneration. J Virol 1993; 67: 1424–1432.
34. Pastrana DV, Brennan DC, Cuburu N, et al. Neutralization serotyping of BK polyomavirus infection in kidney transplant recipients. PLoS Pathog 2012; 8: e1002650.
35. Randhawa P, Pastrana DV, Zeng G, et al. Commercially available immunoglobulins contain virus neutralizing antibodies against all major genotypes of polyomavirus BK. Am J Transplant 2015; 15: 1014–1020.
36. Hirsch HH, Babel N, Comoli P, et al. European perspective on human polyomavirus infection, replication and disease in solid organ transplantation. Clin Microbiol Infect 2014; 20 (Suppl 7): 74–88.
37. Schmidt T, Adam C, Hirsch HH, et al. BK polyomavirus-specific cellular immune responses are age-dependent and strongly correlate with phases of virus replication. Am J Transplant 2014; 14: 1334–1345.
38. Hirsch HH, Randhawa P. BK polyomavirus in solid organ transplantation. Am J Transplant 2013; 13 (Suppl 4): 179–188.