Transient versus persistent BK viremia and long-term outcomes after kidney and kidney-pancreas transplantation

Clinical Journal of the American Society of Nephrology

Volumn 9, Issue 3, 2014, Pages 553-561

  Elfadawy, Nissreen ^a   Flechner, Stuart M ^a   Schold, Jesse D ^a   Srinivas, Titte R ^a   Poggio, Emilio ^a   Fatica, Richard ^a   Avery, Robin ^b   Mossad, Sherif B ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BASILIXIMAB; CIPROFLOXACIN; CYCLOSPORIN; LEFLUNOMIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; BK VIRUS INFECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; FEMALE; FOLLOW UP; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; INCIDENCE; KIDNEY PANCREAS TRANSPLANTATION; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; SCORING SYSTEM; SCREENING TEST; TREATMENT OUTCOME; VIREMIA; VIRUS LOAD;

BK VIRUS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; KAPLAN-MEIER ESTIMATE; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; OHIO; PANCREAS TRANSPLANTATION; POLYOMAVIRUS INFECTIONS; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TUMOR VIRUS INFECTIONS; VIRAL LOAD; VIREMIA;

EID: 84896837750     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.08420813     Document Type: Article

References (25)

1. Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, Mihatsch MJ, Nickeleit V, Ramos E, Randhawa P, Shapiro R, Steiger J, Suthanthiran M, Trofe J: Polyomavirusassociated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation 79: 1277-1286, 2005.
2. Nickeleit V, Hirsch HH, Binet IF, Gudat F, Prince O, Dalquen P, Thiel G, Mihatsch MJ: Polyomavirus infection of renal allograft recipients: From latent infection to manifest disease. J Am Soc Nephrol 10: 1080-1089, 1999.
3. Ramos E, Drachenberg CB, Papadimitriou JC, Hamze O, Fink JC, Klassen DK, Drachenberg RC, Wiland A, Wali R, Cangro CB, Schweitzer E, Bartlett ST, Weir MR: Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J AmSoc Nephrol 13: 2145-2151, 2002.
4. Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J: Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347: 488-496, 2002.
5. Hardinger KL, Koch MJ, Bohl DJ, Storch GA, Brennan DC: BKvirus and the impact of pre-emptive immunosuppression reduction: 5-year results. Am J Transplant 10: 407-415, 2010.
6. Babel N, Fendt J, Karaivanov S, Bold G, Arnold S, Sefrin A, Lieske E, Hoffzimmer M, Dziubianau M, Bethke N, Meisel C, Grütz G, Reinke P: Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: Analysis of 4128 urine and serum samples. Transplantation 88: 89-95, 2009.
7. Hirsch HH, Steiger J: Polyomavirus BK. Lancet Infect Dis 3: 611- 623, 2003.
8. Pollara CP, Corbellini S, Chiappini S, Sandrini S, De Tomasi D, Bonfanti C, Manca N: Quantitative viral load measurement for BKVinfection in renal transplant recipients as a predictive tool for BKVAN. New Microbiol 34: 165-171, 2011.
9. Hirsch HH, Randhawa P; AST Infectious Diseases Community of Practice: BK virus in solid organ transplant recipients. Am J Transplant 9[Suppl 4]: S136-S146, 2009.
10. Chung BH, Hong YA, Kim HG, Sun IO, Choi SR, Park HS, Lee SH, Choi BS, Park CW, Choi YJ, Kim YS, Yang CW: Clinical usefulness of BK virus plasma quantitative PCR to prevent BK virus associated nephropathy. Transpl Int 25: 687-695, 2012.
11. Pöge U, Gerhardt T, Palmedo H, Klehr HU, Sauerbruch T,Woitas RP: MDRD equations for estimation of GFR in renal transplant recipients. Am J Transplant 5: 1306-1311, 2005.
12. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG: Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42: 377-381, 2009.
13. Hirsch HH, Vincenti F, Friman S, Tuncer M, Citterio F, Wiecek A, Scheuermann EH, Klinger M, Russ G, Pescovitz MD, Prestele H: Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: A prospective, randomized, multicenter study. Am J Transplant 13: 136-145, 2013.
14. Elfadawy N, Flechner SM, Liu X, Schold J, Srinivas TR, Poggio E, Fatica R, Avery R, Mossad SB: CMV viremia is associated with a decreased incidence of BKV reactivation after kidney and kidney-pancreas transplantation [published online ahead of print September 19, 2013]. Transplantation
15. Liapis H, Storch GA, Hill DA, Rueda J, Brennan DC: CMV infection of the renal allograft is much more common than the pathology indicates: A retrospective analysis of qualitative and quantitative buffy coat CMV-PCR, renal biopsy pathology and tissue CMV-PCR. Nephrol Dial Transplant 18: 397-402, 2003.
16. Schwarz A, Linnenweber-Held S, Heim A, Bröcker V, Rieck D, Framke T, Raggub L, Haller H: Factors influencing viral clearing and renal function during polyomavirus BK-associated nephropathy after renal transplantation. Transplantation 94: 396-402, 2012.
17. Bohl DL, Storch GA, Ryschkewitsch C, Gaudreault-Keener M, Schnitzler MA, Major EO, Brennan DC: Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant 5: 2213-2221, 2005.
18. Schaub S, Hirsch HH, Dickenmann M, Steiger J, Mihatsch MJ, Hopfer H, Mayr M: Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirusassociated nephropathy. Am J Transplant 10: 2615-2623, 2010.
19. Blyth E, Clancy L, Simms R, Gaundar S, O'Connell P, Micklethwaite K, Gottlieb DJ: BK virus-specific T cells for use in cellular therapy show specificity to multiple antigens and polyfunctional cytokine responses. Transplantation 92: 1077-1084, 2011.
20. Zhou W, Sharma M, Martinez J, Srivastava T, Diamond DJ, Knowles W, Lacey SF: Functional characterization of BK virusspecific CD4+ T cells with cytotoxic potential in seropositive adults. Viral Immunol 20: 379-388, 2007.
21. Ahuja M, Cohen EP, Dayer AM, Kampalath B, Chang CC, Bresnahan BA, Hariharan S: Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis. Transplantation 71: 896-899, 2001.
22. Hirsch HH: Polyomavirus BK nephropathy: A (re-)emerging complication in renal transplantation. Am J Transplant 2: 25-30, 2002.
23. Hussain S, Bresnahan BA, Cohen EP, Hariharan S: Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. Clin Transplant 16: 43-47, 2002.
24. Vasudev B, Hariharan S, Hussain SA, Zhu YR, Bresnahan BA, Cohen EP: BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients. Kidney Int 68: 1834-1839, 2005.
25. Drachenberg CB, Papadimitriou JC, Hirsch HH, Wali R, Crowder C, Nogueira J, Cangro CB, Mendley S, Mian A, Ramos E: Histological patterns of polyomavirus nephropathy: Correlation with graft outcome and viral load. Am J Transplant 4: 2082-2092, 2004