Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy

ACS Nano

Volumn 10, Issue 10, 2016, Pages 9216-9226

  Frick, Stefanie U ^a   Domogalla, Matthias P ^a,b   Baier, Grit ^b   Wurm, Frederik R ^b   Mailänder, Volker ^a,b   Landfester, Katharina ^b   Steinbrink, Kerstin ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

Author keywords

click chemistry; human; hydroxyethyl starch; immunotherapy; interleukin 2; murine; nanocapsules; T cells

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; CELLS; CYTOLOGY; MEDICAL APPLICATIONS; NANOCAPSULES; STARCH; T-CELLS;

CLICK CHEMISTRY; HUMAN; HYDROXYETHYL STARCHES; IMMUNOTHERAPY; INTERLEUKIN-2; MURINE;

CELL ENGINEERING;

EID: 84994030749     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b07973     Document Type: Article

References (39)

1. Steinman, R. M.; Banchereau, J. Taking Dendritic Cells into Medicine Nature 2007, 449, 419-426 10.1038/nature06175
2. Paulis, L. E.; Mandal, S.; Kreutz, M.; Figdor, C. G. Dendritic Cell-Based Nanovaccines for Cancer Immunotherapy Curr. Opin. Immunol. 2013, 25, 389-395 10.1016/j.coi.2013.03.001
3. Tang, Q.; Bluestone, J. A. The Foxp3+ Regulatory T Cell: a Jack of all Trades, Master of Regulation Nat. Immunol. 2008, 9, 239-244 10.1038/ni1572
4. Chaput, N.; Conforti, R.; Viaud, S.; Spatz, A.; Zitvogel, L. The Janus Face of Dendritic Cells in Cancer Oncogene 2008, 27, 5920-5931 10.1038/onc.2008.270
5. Priyadharshini, B.; Greiner, D. L.; Brehm, M. A. T-Cell Activation and Transplantation Tolerance Transplant. Rev. 2012, 26, 212-22 10.1016/j.trre.2011.09.002
6. Islam, S. A.; Luster, A. D. T Cell Homing to Epithelial Barriers in Allergic Disease Nat. Med. 2012, 18, 705-715 10.1038/nm.2760
7. Blazar, B. R.; Murphy, W. J.; Abedi, M. Advances in Graft-Versus-Host Disease Biology and Therapy Nat. Rev. Immunol. 2012, 12, 443-458 10.1038/nri3212
8. Bluestone, J. A.; Bour-Jordan, H.; Cheng, M.; Anderson, M. T Cells in the Control of Organ-Specific Autoimmunity J. Clin. Invest. 2015, 125, 2250-2260 10.1172/JCI78089
9. Steward-Tharp, S. M.; Song, Y. J.; Siegel, R. M.; O'Shea, J. J. New Insights Into T Cell Biology and T Cell-Directed Therapy for Autoimmunity, Inflammation, and Immunosuppression Ann. N. Y. Acad. Sci. 2010, 1183, 123-148 10.1111/j.1749-6632.2009.05124.x
10. Serra, P.; Santamaria, P. Nanoparticle-Based Autoimmune Disease Therapy Clin. Immunol. 2015, 160, 3-13 10.1016/j.clim.2015.02.003
11. Shao, K.; Singha, S.; Clemente-Casares, X.; Tsai, S.; Yang, Y.; Santamaria, P. Nanoparticle-Based Immunotherapy for Cancer ACS Nano 2015, 9, 16-30 10.1021/nn5062029
12. Lowenthal, J. W.; MacDonald, H. R.; Iacopetta, B. J. Intracellular Pathway of Interleukin 2 Following Receptor-Mediated Endocytosis Eur. J. Immunol. 1986, 16, 1461-1463 10.1002/eji.1830161125
13. Malek, T. R. The Biology of Interleukin-2 Annu. Rev. Immunol. 2008, 26, 453-479 10.1146/annurev.immunol.26.021607.090357
14. Boyman, O.; Sprent, J. The Role of Interleukin-2 during Homeostasis and Activation of the Immune System Nat. Rev. Immunol. 2012, 12, 180-190 10.1038/nri3156
15. Saadoun, D.; Rosenzwajg, M.; Joly, F.; Six, A.; Carrat, F.; Thibault, V.; Sene, D.; Cacoub, P.; Klatzmann, D. Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis N. Engl. J. Med. 2011, 365, 2067-2077 10.1056/NEJMoa1105143
16. Yu, A.; Zhu, L.; Altman, N. H.; Malek, T. R. A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells Immunity 2009, 30, 204-217 10.1016/j.immuni.2008.11.014
17. Malek, T. R.; Castro, I. Interleukin-2 Receptor Signaling: at the Interface Between Tolerance and Immunity Immunity 2010, 33, 153-165 10.1016/j.immuni.2010.08.004
18. Baier, G.; Baumann, D.; Siebert, J. M.; Musyanovych, A.; Mailander, V.; Landfester, K. Suppressing Unspecific Cell Uptake for Targeted Delivery using Hydroxyethyl Starch Nanocapsules Biomacromolecules 2012, 13, 2704-2715 10.1021/bm300653v
19. Kolb, H. C.; Sharpless, K. B. The Growing Impact of Click Chemistry on Drug Discovery Drug Discovery Today 2003, 8, 1128-1137 10.1016/S1359-6446(03)02933-7
20. Duprez, V.; Ferrer, M.; Cornet, V.; Olive, D.; Dautry-Varsat, A. Modulation of Interleukin 2 Internalization and Interleukin 2-Dependent Cell Growth by Antireceptor Antibodies J. Biol. Chem. 1991, 266, 1497-1501
21. Lamaze, C.; Dujeancourt, A.; Baba, T.; Lo, C. G.; Benmerah, A.; Dautry-Varsat, A. Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway Mol. Cell 2001, 7, 661-671 10.1016/S1097-2765(01)00212-X
22. Rejman, J.; Oberle, V.; Zuhorn, I. S.; Hoekstra, D. Size-Dependent Internalization of Particles via the Pathways of Clathrin- and Caveolae-Mediated Endocytosis Biochem. J. 2004, 377, 159-169 10.1042/bj20031253
23. Du, J. M.; Yang, H.; Zhang, D. P.; Wang, J. C.; Guo, H. Z.; Peng, B. Z.; Guo, Y. J.; Ding, J. P. Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab J. Immunol. 2010, 184, 1361-1368 10.4049/jimmunol.0903178
24. Klatzmann, D.; Abbas, A. K. The Promise of Low-Dose Interleukin-2 Therapy for Autoimmune and Inflammatory Diseases Nat. Rev. Immunol. 2015, 15, 283-294 10.1038/nri3823
25. Baier, G.; Siebert, J. M.; Landfester, K.; Musyanovych, A. Surface Click Reactions on Polymeric Nanocapsules for Versatile Functionalization Macromolecules 2012, 45, 3419-3427 10.1021/ma300312n
26. Xie, F.; Sivakumar, K.; Zeng, Q. B.; Bruckman, M. A.; Hodges, B.; Wang, Q. A Fluorogenic 'Click' Reaction of Azidoanthracene Derivatives Tetrahedron 2008, 64, 2906-2914 10.1016/j.tet.2008.01.080
27. + Regulatory T Cells in the Human Immune System Nat. Rev. Immunol. 2010, 10, 490-500 10.1038/nri2785
28. Liu, M. Y.; Miao, T. Z.; Zhu, H. X.; Symonds, A. L. J.; Li, L.; Schurich, A.; Maini, M. K.; Zhang, J. M.; Kennedy, P. T. F.; Li, S. L.; Wang, P. IL-2-Engineered Nano-APC Effectively Activates Viral Antigen-Mediated T Cell Responses from Chronic Hepatitis B Virus-Infected Patients J. Immunol. 2012, 188, 1534-1543 10.4049/jimmunol.1102709
29. Park, J.; Wrzesinski, S. H.; Stern, E.; Look, M.; Criscione, J.; Ragheb, R.; Jay, S. M.; Demento, S. L.; Agawu, A.; Limon, P. L.; Ferrandino, A. F.; Gonzalez, D.; Habermann, A.; Flavell, R. A.; Fahmy, T. M. Combination Delivery of TGF-beta Inhibitor and IL-2 by Nanoscale Liposomal Polymeric Gels Enhances Tumour Immunotherapy Nat. Mater. 2012, 11, 895-905 10.1038/nmat3355
30. Fadel, T. R.; Sharp, F. A.; Vudattu, N.; Ragheb, R.; Garyu, J.; Kim, D.; Hong, E.; Li, N.; Haller, G. L.; Pfefferle, L. D.; Justesen, S.; Herold, K. C.; Fahmy, T. M. A Carbon Nanotube-Polymer Composite for T-Cell Therapy Nat. Nanotechnol. 2014, 9, 639-647 10.1038/nnano.2014.154
31. McHugh, M. D.; Park, J.; Uhrich, R.; Gao, W.; Horwitz, D. A.; Fahmy, T. M. Paracrine Co-Delivery of TGF-beta and IL-2 using CD4-Targeted Nanoparticles for Induction and Maintenance of Regulatory T Cells Biomaterials 2015, 59, 172-181 10.1016/j.biomaterials.2015.04.003
32. Konigsberg, P. J.; Godtel, R.; Kissel, T.; Richer, L. L. The Development of IL-2 Conjugated Liposomes for Therapeutic Purposes Biochim. Biophys. Acta, Biomembr. 1998, 1370, 243-251 10.1016/S0005-2736(97)00269-1
33. Zheng, Y.; Stephan, M. T.; Gai, S. A.; Abraham, W.; Shearer, A.; Irvine, D. J. In Vivo Targeting of Adoptively Transferred T-Cells with Antibody- and Cytokine-Conjugated Liposomes J. Controlled Release 2013, 172, 426-435 10.1016/j.jconrel.2013.05.037
34. Rosenberg, S. A. IL-2: the First Effective Immunotherapy for Human Cancer J. Immunol. 2014, 192, 5451-5458 10.4049/jimmunol.1490019
35. Arenas-Ramirez, N.; Woytschak, J.; Boyman, O. Interleukin-2: Biology, Design and Application Trends Immunol. 2015, 36, 763-777 10.1016/j.it.2015.10.003
36. Yu, A.; Snowhite, I.; Vendrame, F.; Rosenzwajg, M.; Klatzmann, D.; Pugliese, A.; Malek, T. R. Selective IL-2 Responsiveness of Regulatory T Cells through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes Diabetes 2015, 64, 2172-2183 10.2337/db14-1322
37. von Spee-Mayer, C.; Siegert, E.; Abdirama, D.; Rose, A.; Klaus, A.; Alexander, T.; Enghard, P.; Sawitzki, B.; Hiepe, F.; Radbruch, A.; Burmester, G. R.; Riemekasten, G.; Humrich, J. Y. Low-Dose Interleukin-2 Selectively Corrects Regulatory T Cell Defects in Patients with Systemic Lupus Erythematosus Ann. Rheum. Dis. 2016, 75, 1407-1415 10.1136/annrheumdis-2015-207776
38. Schlaad, H.; Kukula, H.; Rudloff, J.; Below, I. Synthesis of Alpha,omega-heterobifunctional Poly(ethylene glycol)s by Metal-Free Anionic Ring-Opening Polymerization Macromolecules 2001, 34, 4302-4304 10.1021/ma010311+
39. Wang, X. L.; Xie, S. G.; Zhang, L.; Yang, W. X.; Wang, X.; Jin, H. Z. Comparison of Ligase Detection Reaction and Real-Time PCR for Detection of Low Abundant YMDD Mutants in Patients with Chronic Hepatitis B World J. Gastroenterol. 2008, 14, 120-124 10.3748/wjg.14.120