Molecular mechanisms of anti-metastatic activity of curcumin

Anticancer Research

Volumn 36, Issue 11, 2016, Pages 5639-5647

  Deng, Yi ^a   Verron, Elise ^b   Rohanizadeh, Ramin ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITÉ DE NANTES   (France)

Author keywords

Cancer invasion; Cancer treatment and prevention; Curcumin; Metastasis; Review; Signaling pathways

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CYTOKINE; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MICRORNA; MICRORNA 181B; MICRORNA 21; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UROKINASE;

ANTIOXIDANT ACTIVITY; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; ENZYME INACTIVATION; HUMAN; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; NEOPLASM METASTASIS; PREVENTION AND CONTROL; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; CURCUMIN; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 84994000472     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: 10.21873/anticanres.11147     Document Type: Review

References (65)

1. Bray F, Ren JS, Masuyer E and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 132: 1133-1145, 2013.
2. Coghlin C and Murray GI: Current and emerging concepts in tumour metastasis. J Pathol 222: 1-15, 2010.
3. Brooks SA, Lomax-Browne HJ, Carter TM, Kinch CE and Hall DMS: Molecular interactions in cancer cell metastasis. Acta Histochem 112: 3-25, 2010.
4. Helbig G, Christopherson KW, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, Broxmeyer HE and Nakshatri H: NF-kappa B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278: 21631-21638, 2003.
5. Liotta LA: Cancer - An attractive force in metastasis. Nature 410: 24-25, 2001.
6. Gupta SC, Patchva S, Koh W and Aggarwal BB: Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol P 39: 283-299, 2012.
7. Lee WH, Bebawy M, Loo CY, Luk F, Mason RS and Rohanizadeh R: Fabrication of Curcumin Micellar Nanoparticles with Enhanced Anti-Cancer Activity. J Biomed Nanotechnol 11: 1093-1105, 2015.
8. Lee WH, Loo CY, Bebawy M, Luk F, Mason RS and Rohanizadeh R: Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol 11: 338-378, 2013.
9. Lee WH, Loo CY, Young PM, Rohanizadeh R and Traini D: Curcumin nanoparticles attenuate production of pro-inflammatory markers in lipopolysaccharide-induced macrophages. Pharm Res-Dordr 33: 315-327, 2016.
10. Lee WH, Loo CY, Young PM, Traini D, Mason RS and Rohanizadeh R: Recent advances in curcumin nanoformulation for cancer therapy. Expert Opin Drug Del 11: 1183-1201, 2014.
11. Zong H, Wang F, Fan QX and Wang LX: Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Mol Biol Rep 39: 4803-4808, 2012.
12. Hassan ZK and Daghestani MH: Curcumin Effect on MMPs and TIMPs Genes in a Breast Cancer Cell Line. Asian Pac J Cancer P 13: 3259-3264, 2012.
13. Lin SS, Lai KC, Hsu SC, Yang JS, Kuo CL, Lin JP, Ma YS, Wu CC and Chung JG: Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and-9 and Vascular Endothelial Growth Factor (VEGF). Cancer Lett 285: 127-133, 2009.
14. Kim JM, Noh EM, Kwon KB, Kim JS, You YO, Hwang JK, Hwang BM, Kim BS, Lee SH, Lee SJ, Jung SH, Youn HJ and Lee YR: Curcumin suppresses the TPA-induced invasion through inhibition of PKC alpha-dependent MMP-expression in MCF-7 human breast cancer cells. Phytomedicine 19: 1085-1092, 2012.
15. Wang SJ, Yu SJ, Shi W, Ge L, Yu X, Fan JH and Zhang JN: Curcumin Inhibits the Migration and Invasion of Mouse Hepatoma Hca-F Cells Through Down-regulating Caveolin-1 Expression and Epidermal Growth Factor Receptor Signaling. Iubmb Life 63: 775-782, 2011.
16. Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, Liu XB, Li Y and Li Z: Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One 7(5): e37960, 2012.
17. Shishodia S: Molecular mechanisms of curcumin action: Gene expression. Biofactors 39: 37-55, 2013.
18. Fan YH, Mao RF and Yang JH: NF-kappa B and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell 4: 176-185, 2013.
19. Aggarwal BB: Nuclear factor-kappa-B: The enemy within. Cancer Cell 6: 203-208, 2004.
20. Jacobs MD and Harrison SC: Structure of an I kappa B alpha/NF-kappa B complex. Cell 95: 749-758, 1998.
21. Verma IM, Stevenson JK, Schwarz EM, Vanantwerp D and Miyamoto S: Rel/Nf-Kappa-B/I-Kappa-B Family - Intimate Tales of Association and Dissociation. Gene Dev 9: 2723-2735, 1995.
22. Nelson DE, Ihekwaba AEC, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB and White MRH: Oscillations in NF-kappa B signaling control the dynamics of gene expression. Science 306: 704-708, 2004.
23. Baldwin AS: Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappa B. J Clin Invest 107: 241-246, 2001.
24. Kunnumakkara AB, Anand P and Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269: 199-225, 2008.
25. Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Hohneke C, Jochum M, Nerlich AG and Pfeffer U: Curcumin down-regulates the inflammatory cytokines CXCL1 and-2 in breast cancer cells via NF kappa B. Carcinogenesis 29: 779-789, 2008.
26. Killian PH, Kronski E, Michalik KM, Barbieri O, Astigiano S, Sommerhoff CP, Pfeffer U, Nerlich AG and Bachmeier BE: Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2. Carcinogenesis 33: 2507-2519, 2012.
27. Singh S and Aggarwal BB: Activation of Transcription Factor Nf-Kappa-B Is Suppressed by Curcumin (Diferulolylmethane). J Biol Chem 270: 24995-25000, 1995.
28. Angel P, Hattori K, Smeal T and Karin M: The Jun Proto-Oncogene Is Positively Autoregulated by Its Product, Jun/Ap-1. Cell 55: 875-885, 1988.
29. Park J and Conteas CN: Anti-carcinogenic properties of curcumin on colorectal cancer. World journal of gastrointestinal oncology 2: 169-176, 2010.
30. Wang XF, Wang QD, Ives KL and Evers BM: Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 12: 5346-5355, 2006.
31. Huang SY: Regulation of Metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications. Clin Cancer Res 13: 1362-1366, 2007.
32. Lu HT, Ouyang WM and Huang CS: Inflammation, a key event in cancer development. Mol Cancer Res 4: 221-233, 2006.
33. Rollins BJ: Inflammatory chemokines in cancer growth and progression. Eur J Cancer 42: 760-767, 2006.
34. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Vandamme J, Walz A, Marriott D, Chan S Y, Roczniak S and Shanafelt AB: The functional-role of the Elr Motif in Cxc chemokine-mediated angiogenesis. J Biol Chem 270: 27348-27357, 1995.
35. Youngs SJ, Ali SA, Taub DD and Rees RC: Chemokines induce migrational responses in human breast carcinoma cell lines. Int J Cancer 71: 257-266, 1997.
36. Freund A, Chauveau C, Brouillet JP, Lucas A, Lacroix M, Licznar A, Vignon F and Lazennec G: IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene 22: 256-265, 2003.
37. Li AH, Varney ML and Singh RK: Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res 7: 3298-3304, 2001.
38. Li L, Braiteh FS and Kurzrock R: Liposome-encapsulated curcumin - In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 104: 1322-1331, 2005.
39. Chirco R, Liu XW, Jung KK and Kim HRC: Novel functions of TIMPs in cell signaling. Cancer Metast Rev 25: 99-113, 2006.
40. Mylona E, Magkou C, Giannopoulou I, Agrogiannis G, Markaki S, Keramopoulos A and Nakopoulou L: Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor phenotype and clinical outcome. Breast Cancer Res 8, 2006.
41. Lee SO, Jeong YJ, Kim M, Kim CH and Lee IS: Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-kappa B-dependent MMP-9 expression. Biochem Bioph Res Co 366: 1019-1024, 2008.
42. Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Heber D and Nguyen M: Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer 98: 234-240, 2002.
43. GomisRuth FX, Maskos K, Betz M, Bergner A, Huber R, Suzuki K, Yoshida N, Nagase H, Brew K, Bourenkov GP, Bartunik H and Bode W: Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature 389: 77-81, 1997.
44. Farhangi B, Alizadeh AM, Khodayari H, Khodayari S, Dehghan MJ, Khori V, Heidarzadeh A, Khaniki M, Sadeghiezadeh M and Najafi F: Protective effects of dendrosomal curcumin on an animal metastatic breast tumor. Eur J Pharmacol 758: 188-196, 2015.
45. Chen QY, Zheng Y, Jiao DM, Chend FY, Hu HZ, Wu YQ, Song J, Yan J, Wu LJ and Lv GY: Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway. J Nutr Biochem 25: 177-185, 2014.
46. Sun K, Duan XY, Cai H, Liu XH, Yang Y, Li M, Zhang XY and Wang JS: Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells. Clin Exp Med 16: 37-47, 2016.
47. Cheng TS, Chen WC, Lin YY, Tsai CH, Liao CI, Shyu HY, Ko CJ, Tzeng SF, Huang CY, Yang PC, Hsiao PW and Lee MS: Curcumin-Targeting Pericellular Serine Protease Matriptase Role in Suppression of Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis. Cancer Prev Res 6: 495-505, 2013.
48. Cox BD, Natarajan M, Stettner MR and Gladson CL: New concepts regarding focal promotion of cell migration adhesion kinase and proliferation. J Cell Biochem 99: 36-52, 2006.
49. Chen CC, Sureshbabul M, Chen HW, Lin YS, Lee JY, Hong QS, Yang YC and Yu SL: Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evid-Based Compl Alt 2013.
50. Leu TH, Su SL, Chuang YC and Maa MC: Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity. Biochem Pharmacol 66: 2323-2331, 2003.
51. Mudduluru G, Gerge-William JN, Muppala S, Asangani IA, Kumarswamy R, Nelson LD and Allgayer H: Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. Bioscience Rep 31: 185-197, 2011.
52. Tili E, Michaille JJ and Croce CM: MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev 253: 167-184, 2013.
53. Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, Bruno A, Pagani A, Rovera F, Pfeffer U, Sommerhoff CP, Noonan DM, Nerlich AG, Fontana L and Bachmeier BE: miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and-2. Mol Oncol 8: 581-595, 2014.
54. Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF, Huang CW, Ho CC, Chen JJW, Tsai MF, Yu SL and Yang PC: Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 68: 7428-7438, 2008.
55. Duarte VM, Han E, Veena MS, Salvado A, Suh JD, Liang LJ, Faull KF, Srivatsan ES and Wang MB: Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKK beta protein of the NF kappa B pathway. Mol Cancer Ther 9: 2665-2675, 2010.
56. LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES and Wang MB: Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res 11: 6994-7002, 2005.
57. Yin HT, Guo R, Xu Y, Zheng YL, Hou ZB, Dai XZ, Zhang ZD, Zheng DH and Xu H: Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer. Acta Bioch Bioph Sin 44: 147-153, 2012.
58. Shakibaei M, Kraehe P, Popper B, Shayan P, Goel A and Buhrmann C: Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. Bmc Cancer 15, 2015.
59. Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ and Sonenshein GE: Her-2/neu overexpression induces NF-kappa B via a PI3-kinase/Akt pathway involving calpain-mediated degradation of I kappa-B-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene 20: 1287-1299, 2001.
60. Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE and Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor-kappa B pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11: 7490-7498, 2005.
61. Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier MA, Durando X, Barthomeuf C and Chollet P: Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther 9: 8-14, 2010.
62. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Wu MS, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC and Hsieh CY: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21: 2895-2900, 2001.
63. Dhillon N, Aggarwal BB, Newman RA, Wolf RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V and Kurzrock R: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14: 4491-4499, 2008.
64. Yan L: Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice. Int J Cancer 132: 269-275, 2013.
65. Yan L, Yee JA and Cao J: Curcumin Reduces Trabecular and Cortical Bone in Naive and Lewis Lung Carcinoma-bearing Mice. Anticancer Res 33: 3153-3161, 2013.