MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles

Biomaterials

Volumn 112, Issue , 2017, Pages 336-345

  Qiao, Hongyu ^a,b   Wang, Yabin ^a   Zhang, Ruohan ^b   Gao, Quansheng ^e   Liang, Xiao ^c   Gao, Lei ^a   Jiang, Zhenhua ^b   Qiao, Ruirui ^d   Han, Dong ^b   Zhang, Yan ^a   Qiu, Ya ^a   Tian, Jie ^c   Gao, Mingyuan ^d   Cao, Feng ^a,b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF AUTOMATION   (China)

^d INSTITUTE OF CHEMISTRY   (China)

^e BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Atherosclerotic plaques; Dual modality molecular imaging; Macrophages; Nanoparticles

Indexed keywords

MACROPHAGES; MOLECULAR IMAGING; NANOPARTICLES; PROBES;

ACUTE CORONARY SYNDROMES; ATHEROSCLEROTIC LESIONS; ATHEROSCLEROTIC PLAQUE; CONTRAST ENHANCEMENT; DUAL MODALITY; DUAL-MODALITY IMAGING; FLUORESCENCE IMAGING; NON-INVASIVE DETECTION;

MAGNETIC RESONANCE IMAGING;

CHOLESTEROL; CY5.5 N HYDROXYSUCCINIMIDE; FLUORESCENT DYE; IMMUNOGLOBULIN G; MAGNETITE NANOPARTICLE; N HYDROXYSUCCINIMIDE; OSTEOPONTIN; SUCCIMER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ATHEROSCLEROTIC PLAQUE; BINDING AFFINITY; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYTOTOXICITY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; FEMALE; FLUORESCENCE IMAGING; FLUORESCENCE IMAGING SYSTEM; HYDRODYNAMICS; IMAGING SOFTWARE; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; MOLECULAR IMAGING; MOUSE; MULTIMODAL IMAGING; NANOPROBE; NANOTOXICOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAW 264.7 CELL LINE; SIGNAL DETECTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ZETA POTENTIAL; ANIMAL; C57BL MOUSE; CAROTID ARTERY DISEASE; CHEMISTRY; DIAGNOSTIC IMAGING; GENETIC PROCEDURES; KNOCKOUT MOUSE; METABOLISM; OPTICAL TOMOGRAPHY; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ULTRASTRUCTURE;

ANIMALS; CAROTID ARTERY DISEASES; FEMALE; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR PROBE TECHNIQUES; MULTIMODAL IMAGING; OSTEOPONTIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, OPTICAL;

EID: 84993983163     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.10.011     Document Type: Article

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