Focusing osteoarthritis management on modifiable risk factors and future therapeutic prospects

Therapeutic Advances in Musculoskeletal Disease

Volumn 1, Issue 1, 2009, Pages 35-47

  Hunter, David J ^a  

^a NEW ENGLAND BAPTIST HOSPITAL   (United States)

Author keywords

management; nonpharmacologic; osteoarthritis

Indexed keywords

EID: 84993804670     PISSN: 1759720X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1759720X09342132     Document Type: Review

References (130)

1. ( 1994) Arthritis prevalence and activity limitations-United States, 1990. MMWR Morb Mortal Wkly Rep 43: 433-438.
2. ( 1998) Prevalence and impact of chronic joint symptoms-seven states, 1996. MMWR Morb Mortal Wkly Rep 47: 345-351.
3. ( 2001) Prevalence of disabilities and associated health conditions among adults-United States, 1999. MMWR Morb Mortal Wkly Rep 50: 120-125.
4. ( 2005) Review: Both aerobic and home-based quadriceps strengthening exercises reduce pain and disability in knee osteoarthritis. ACP Journal Club 143: 71.
5. (2009) Guideline on the Treatment of Osteoarthritis (OA) of the Knee. Internet Communication.
6. Abramson, S.B., Attur, M. and Yazici, Y. ( 2006) Prospects for disease modification in osteoarthritis. Nat Clin Pract Rheumatol 2: 304-312.
7. American Academy of Orthopaedic Surgeons (AAOS) ( 2008) Treatment of osteoarthritis of the knee (nonarthroplasty). Rosemont (IL): American Academy of Orthopaedic Surgeons. p. 263.
8. Amin, S., LaValley, M.P., Guermazi, A., Grigoryan, M., Hunter, D.J., Clancy, M. et al. (2005) The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis. Arthritis Rheum 52: 3152-3159.
9. Andriacchi, T.P. ( 1994) Dynamics of knee malalignment. Orthop Clin North Am 25: 395-403.
10. Andriacchi, T.P., Mundermann, A., Smith, R.L., Alexander, E.J., Dyrby, C.O. and Koo, S. ( 2004) A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng 32: 447-457.
11. Anonymous (2000) Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 43: 1905-1915.
12. Balint, G., Rooney, P.J. and Buchanan, W.W. ( 1987) A legacy for rheumatology from Sir William Osler. Clin Rheumatol 6: 423-435.
13. Baratz, M.E., Fu, F.H. and Mengato, R. ( 1986) Meniscal tears: the effect of meniscectomy and of repair on intraarticular contact areas and stress in the human knee. A preliminary report. Am J Sports Med 14: 270-275.
14. Bellamy, E., Wilson, C. and Bellamy, N. (2009) Osteoarthritis measurement in routine rheumatology outpatient practice (OMIRROP) in Australia: A survey of practice style, instrument use, responder criteria, and state-attainment criteria. J Rheumatol 36 (5): 1049-1055.
15. Bhattacharyya, T., Gale, D., Dewire, P., Totterman, S., Gale, M.E., McLaughlin, S. et al. (2003) The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee. J Bone Joint Surg Am 85-A: 4-9.
16. Blin, O., Pailhous, J., Lafforgue, P. and Serratrice, G. ( 1990) Quantitative analysis of walking in patients with knee osteoarthritis: a method of assessing the effectiveness of non-steroidal anti-inflammatory treatment. Ann Rheum Dis 49: 990-993.
17. Brandt, K.D., Radin, E.L., Dieppe, P.A. and van De, P.L. ( 2006) Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 65: 1261-1264.
18. Brinker, M.R., O'Connor, D.P., Pierce, P., Woods, G.W. and Elliott, M.N. ( 2002) Utilization of orthopaedic services in a capitated population. J Bone Joint Surg Am 84-A: 1926-1932.
19. Carter, D.R., Beaupre, G.S., Wong, M., Smith, R.L., Andriacchi, T.P. and Schurman, D.J. ( 2004) The mechanobiology of articular cartilage development and degeneration. Clin Orthop Relat Res S69-S77.
20. Centers for Disease Control and Prevention (CDC). ( 2007) National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic conditions-United States, 2003. MMWR Morb Mortal Wkly Rep 56: 4-7.
21. Cerejo, R., Dunlop, D.D., Cahue, S., Channin, D., Song, J. and Sharma, L. ( 2002) The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease. Arthritis Rheum 46: 2632-2636.
22. Chard, J., Dickson, J., Tallon, D. and Dieppe, P. ( 2002) A comparison of the views of rheumatologists, general practitioners and patients on the treatment of osteoarthritis. Rheumatology 41: 1208-1210.
23. Chassany, O., Boureau, F., Liard, F., Bertin, P., Serrie, A., Ferran, P. et al. (2006) Effects of training on general practitioners’ management of pain in osteoarthritis: a randomized multicenter study. J Rheumatol 33: 1827-1834.
24. Clegg, D.O., Reda, D.J., Harris, C.L., Klein, M.A., O'Dell, J.R., Hooper, M.M. et al. (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Eng J Med 354: 795-808.
25. Coggon, D., Reading, I., Croft, P., McLaren, M., Barrett, D., Cooper, C. et al. (2001) Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord 25: 622-627.
26. Cooperman, D.R., Wallensten, R. and Stulberg, S.D. ( 1983) Acetabular dysplasia in the adult. Clin Orthop Relat Res 175: 79-85.
27. de Haan, M.N., Guzman, J., Bayley, M.T. and Bell, M.J. ( 2007) Knee osteoarthritis clinical practice guidelines - how are we doing ? J Rheumatol 34: 2099-2105.
28. Denoeud, L., Mazieres, B., Payen-Champenois, C. and Ravaud, P. ( 2005) First line treatment of knee osteoarthritis in outpatients in France: adherence to the EULAR 2000 recommendations and factors influencing adherence. Ann Rheum Dis 64: 70-74.
29. Dieppe, P.A. and Lohmander, L.S. ( 2005) Pathogenesis and management of pain in osteoarthritis. Lancet 365: 965-973.
30. Draper, E.R., Cable, J.M., Sanchez-Ballester, J., Hunt, N., Robinson, J.R. and Strachan, R.K. ( 2000) Improvement in function after valgus bracing of the knee. An analysis of gait symmetry. J Bone Joint Surg Br 82: 1001-1005.
31. Dunlop, D.D., Manheim, L.M., Song, J. and Chang, R.W. ( 2001) Arthritis prevalence and activity limitations in older adults. Arthritis Rheum 44: 212-221.
32. Elahi, S., Cahue, S., Felson, D.T., Engelman, L. and Sharma, L. ( 2000) The association between varus-valgus alignment and patellofemoral osteoarthritis. Arthritis Rheum 43: 1874-1880.
33. Englund, M., Guermazi, A., Gale, D., Hunter, D.J., Aliabadi, P., Clancy, M. et al. (2008) Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Eng J Med 359: 1108-1115.
34. Ettinger, W.H.J., Burns, R., Messier, S.P., Applegate, W., Rejeski, W.J., Morgan, T. et al. (1997) A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA 277: 25-31.
35. Eyre, D.R. ( 2004) Collagens and cartilage matrix homeostasis. Clin Orthop Relat Res S 118-122.
36. Felson, D.T. ( 2004a) An update on the pathogenesis and epidemiology of osteoarthritis. Radiol Clin North Am 42: 1-9.
37. Felson, D.T. ( 2004b) Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthop Relat Res S 16-21.
38. Felson, D.T., Goggins, J., Niu, J., Zhang, Y. and Hunter, D.J. ( 2004) The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum 50: 3904-3909.
39. Felson, D.T., Lawrence, R.C., Hochberg, M.C., McAlindon, T., Dieppe, P.A., Minor, M.A. et al. (2000) Osteoarthritis: new insights. Part 2: treatment approaches. Ann Intern Med 133: 726-737.
40. Felson, D.T. and Zhang, Y. ( 1998) An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 41: 1343-1355.
41. Ficat, P. ( 1978) [The syndrome of lateral hyperpressure of the patella]. [French]. Acta Orthop Belg 44: 65-76.
42. Ficat, R.P. and Hungerford, D.S. ( 1977) Disorders of the Patello-femoral Joint, The Williams and Wilkins Co.: Baltimore.
43. Flegal, K.M., Carroll, M.D., Ogden, C.L., Johnson, C.L., Flegal, K.M., Carroll, M.D. et al. (2002) Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288: 1723-1727.
44. Fukubayashi, T. and Kurosawa, H. ( 1980) The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints. Acta Orthop Scand 51: 871-879.
45. Gardiner, P., Graham, R., Legedza, A.T., Ahn, A.C., Eisenberg, D.M. and Phillips, R.S. ( 2007) Factors associated with herbal therapy use by adults in the United States. Altern Ther Health Med 13: 22-29.
46. Glazier, R.H., Dalby, D.M., Badley, E.M., Hawker, G.A., Bell, M.J., Buchbinder, R. et al. (1998) Management of common musculoskeletal problems: a survey of Ontario primary care physicians. CMAJ 158: 1037-1040.
47. Goodman, D.A., Feighan, J.E., Smith, A.D., Latimer, B., Buly, R.L. and Cooperman, D.R. ( 1997) Subclinical slipped capital femoral epiphysis. Relationship to osteoarthrosis of the hip. J Bone Joint Surg Am 79: 1489-1497.
48. Grelsamer, R.P. and Weinstein, C.H. ( 2001) Applied biomechanics of the patella. Clin Orthop Relat Res 389: 9-14.
49. Gross, K.D. and Hillstrom, H.J. ( 2008) Noninvasive devices targeting the mechanics of osteoarthritis. Rheum Dis Clin North Am 34: 755-776.
50. Guccione, A.A., Felson, D.T., Anderson, J.J., Anthony, J.M., Zhang, Y., Wilson, P.W. et al. (1994) The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health 84: 351-358.
51. Hall, M.J. and Lawrence, L. ( 1998) Ambulatory surgery in the United States, 1996. Adv Data 300: 1-16.
52. Hannan, M.T., Felson, D.T. and Pincus, T. ( 2000) Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol 27: 1513-1517.
53. Harris, W.H. ( 1986) Etiology of osteoarthritis of the hip. Clin Orthop Relat Res 213: 20-33.
54. Harrison, M.M., Cooke, T.D., Fisher, S.B. and Griffin, M.P. ( 1994) Patterns of knee arthrosis and patellar subluxation. Clin Orthop Relat Res 309: 56-63.
55. Hassan, B.S., Doherty, S.A., Mockett, S. and Doherty, M. ( 2002) Effect of pain reduction on postural sway, proprioception, and quadriceps strength in subjects with knee osteoarthritis. Ann Rheum Dis 61: 422-428.
56. Hewett, T.E. ( 2000) Neuromuscular and hormonal factors associated with knee injuries in female athletes. Strategies for intervention. Sports Med 29: 313-327.
57. Hinman, R.S., Crossley, K.M., McConnell, J. and Bennell, K.L. ( 2003) Efficacy of knee tape in the management of osteoarthritis of the knee: blinded randomised controlled trial. BMJ 327: 135.
58. Hunter, D.J., Niu, J., Zhang, Y., Totterman, S., Tamez-Pena, J., Dabrowski, C. et al. (2008 a) Change in Cartilage Morphometry: a sample of the progression cohort of the Osteoarthritis Initiative. Ann Rheum Dis 68: 349-356.
59. Hunter, D.J. and Hellio Le Graverand-Gastineau, M.P. ( 2008) How close are we to having structure-modifying drugs available? Rheum Dis Clin North Am 34: 789-802.
60. Hunter, D.J., McDougall, J.J. and Keefe, F.J. ( 2008b) The symptoms of osteoarthritis and the genesis of pain. Rheum Dis Clin North Am 34: 623-643.
61. Hunter, D.J., Patil, V., Niu, J.B., McLennan, C., LaValley, M., Genant, H. et al. (2004) The etiology of knee pain in the community. Arthritis Rheum 50: 1885.
62. Hunter, D.J., Zhang, Y.Q., Niu, J.B., Felson, D.T., Kwoh, K., Newman, A. et al. (2007) Patella malalignment, pain and patellofemoral progression: the Health ABC Study. Osteoarthritis Cartilage 15: 1120-1127.
63. Hunter, D. ( 2007) In the clinic. Osteoarthritis. Ann Intern Med 147: ITC8-IT16
64. Hunter, D. and Felson, D. ( 2006) Osteoarthritis. BMJ 332: 639-642.
65. Hurley, M.V. ( 1999) The role of muscle weakness in the pathogenesis of osteoarthritis. Rheum Dis Clin North Am 25: 283-298.
66. Hurwitz, D.E., Ryals, A.B., Case, J.P., Block, J.A. and Andriacchi, T.P. ( 2002) The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain. J Orthop Res 20: 101-107.
67. Huskisson, E.C., Berry, H., Gishen, P., Jubb, R.W. and Whitehead, J. ( 1995) Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis. J Rheumatol 22: 1941-1946.
68. Huston, L.J., Greenfield, M.L. and Wojtys, E.M. ( 2000) Anterior cruciate ligament injuries in the female athlete. Potential risk factors. Clin Orthop Relat Res 372: 50-63.
69. Hutchings, A., Calloway, M., Choy, E., Hooper, M., Hunter, D.J., Jordan, J.M. et al. (2007) The Longitudinal Examination of Arthritis Pain (LEAP) study: Relationships between weekly fluctuations in patient-rated joint pain and other health outcomes. J Rheumatol 34: 2291-2300.
70. Iwano, T., Kurosawa, H., Tokuyama, H. and Hoshikawa, Y. ( 1990) Roentgenographic and clinical findings of patellofemoral osteoarthrosis. With special reference to its relationship to femorotibial osteoarthrosis and etiologic factors. Clin Orthop Relat Res 252: 190-197.
71. Jackson, B.D., Wluka, A.E., Teichtahl, A.J., Morris, M.E. and Cicuttini, F.M. ( 2004) Reviewing knee osteoarthritis-a biomechanical perspective. J Sci Med Sport 7: 347-357.
72. Jawad, A.S. ( 2005) Analgesics and osteoarthritis: are treatment guidelines reflected in clinical practice ? Am J Ther 12: 98-103.
73. Jordan, K.M., Arden, N.K., Doherty, M., Bannwarth, B., Bijlsma, J.W., Dieppe, P. et al. (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62: 1145-1155.
74. Jordan, K.M., Sawyer, S., Coakley, P., Smith, H.E., Cooper, C. and Arden, N.K. ( 2004) The use of conventional and complementary treatments for knee osteoarthritis in the community. Rheumatology (Oxford) 43: 381-384.
75. Kalichman, L., Zhang, Y.Q., Niu, J.B., Goggins, J., Gale, D., Zhu, Y.Y. et al. (2007 a) The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis. Arthritis Res Ther 9: R26.
76. Kalichman, L., Zhu, Y., Zhang, Y., Niu, J., Gale, D., Felson, D.T. et al. (2007 b) The association between patella alignment and knee pain and function: an MRI study in persons with symptomatic knee osteoarthritis. Osteoarthritis and Cartilage 15: 1235-1240.
77. Karachalios, T., Zibis, A., Papanagiotou, P., Karantanas, A.H., Malizos, K.N., Roidis, N. et al. (2004) MR imaging findings in early osteoarthritis of the knee. Eur J Radiol 50: 225-230.
78. Kerin, A., Patwari, P., Kuettner, K., Cole, A. and Grodzinsky, A. ( 2002) Molecular basis of osteoarthritis: biomechanical aspects. Cell Mol Life Sci 59: 27-35.
79. Kirkley, A., Webster-Bogaert, S., Litchfield, R., Amendola, A., MacDonald, S., McCalden, R. et al. (1999) The effect of bracing on varus gonarthrosis. J Bone Joint Surg Am 81: 539-548.
80. Klaue, K., Durnin, C.W. and Ganz, R. ( 1991) The acetabular rim syndrome. A clinical presentation of dysplasia of the hip. J Bone Joint Surg Br 73: 423-429.
81. Kurosawa, H., Fukubayashi, T. and Nakajima, H. ( 1980) Load-bearing mode of the knee joint: physical behavior of the knee joint with or without menisci. Clin Orthop Relat Res 149: 283-290.
82. Lawrence, R.C., Helmick, C.G., Arnett, F.C., Deyo, R.A., Felson, D.T., Giannini, E.H. et al. (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41: 778-799.
83. Ledingham, J., Regan, M., Jones, A. and Doherty, M. ( 1993) Radiographic patterns and associations of osteoarthritis of the knee in patients referred to hospital. Ann Rheum Dis 52: 520-526.
84. Leunig, M., Werlen, S., Ungersbock, A., Ito, K. and Ganz, R. ( 1997) Evaluation of the acetabular labrum by MR arthrography. J Bone Joint Surg Br 79: 230-234.
85. Lloyd-Roberts, G.C. ( 1955) Osteoarthritis. J Bone Joint Surg Br 37-B: 8-47.
86. Lo, G.H., LaValley, M., McAlindon, T. and Felson, D.T. ( 2003) Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 290: 3115-3121.
87. Madsen, O.R., Brot, C., Petersen, M.M. and Sorensen, O.H. ( 1997) Body composition and muscle strength in women scheduled for a knee or hip- replacement. A comparative study of two groups of osteoarthritic women. Clin Rheumatol 16: 39-44.
88. Mazieres, B., Scmidely, N., Hauselmann, H.J., Martin-Mola, E., Serni, U., Verbruggen, A.A. et al. (2005) Level of acceptability of EULAR recommendations for the management of knee osteoarthritis by practitioners in different European countries. Ann Rheum Dis 64: 1158-1164.
89. McAlindon, T., Zhang, Y., Hannan, M., Naimark, A., Weissman, B., Castelli, W. et al. (1996) Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different ? J Rheumatol 23: 332-337.
90. Messier, S.P., Gutekunst, D.J., Davis, C., DeVita, P., Messier, S.P., Gutekunst, D.J. et al. (2005) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheumat 52: 2026-2032.
91. Messier, S.P., Loeser, R.F., Miller, G.D., Morgan, T.M., Rejeski, W.J., Sevick, M.A. et al. (2004) Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum 50: 1501-1510.
92. Mikesky, A.E., Mazzuca, S.A., Brandt, K.D., Perkins, S.M., Damush, T. and Lane, K.A. ( 2006) Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 55: 690-699.
93. Misso, M.L., Pitt, V.J., Jones, K.M., Barnes, H.N., Piterman, L. and Green, S.E. ( 2008) Quality and consistency of clinical practice guidelines for diagnosis and management of osteoarthritis of the hip and knee: a descriptive overview of published guidelines. Med J Aust 189: 394-399.
94. Miyazaki, T., Wada, M., Kawahara, H., Sato, M., Baba, H. and Shimada, S. ( 2002) Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann Rheum Dis 61: 617-622.
95. Moseley, J.B., O'Malley, K., Petersen, N.J., Menke, T.J., Brody, B.A., Kuykendall, D.H. et al. (2002) A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Eng J Med 347: 81-88.
96. Mundermann, A., Dyrby, C.O., Hurwitz, D.E., Sharma, L. and Andriacchi, T.P. ( 2004) Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed. Arthritis Rheum 50: 1172-1178.
97. Niu, J., Zhang, Y.Q., Nevitt, M., Xu, L., Felson, D.T., Zhu, Y.Y. et al. (2005) Patellar malalignment and knee pain among subjects with no radiographic knee osteoarthritis: The Beijing Osteoarthritis Study. Arthritis Rheum 52: 1191.
98. Ogden, C.L., Carroll, M.D., Curtin, L.R., McDowell, M.A., Tabak, C.J., Flegal, K.M. et al. (2006) Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295: 1549-1555.
99. Ortiz, E. ( 2004) Market withdrawal of Vioxx: is it time to rethink the use of COX-2 inhibitors ? J Manag Care Pharm 10: 551-554.
100. Ouwens, M., Wollersheim, H., Hermens, R., Hulscher, M. and Grol, R. ( 2005) Integrated care programmes for chronically ill patients: a review of systematic reviews. Int J Qual Health Care 17: 141-146.
101. Pencharz, J.N., Grigoriadis, E., Jansz, G.F. and Bombardier, C. ( 2002) A critical appraisal of clinical practice guidelines for the treatment of lower-limb osteoarthritis. Arthritis Res 4: 36-44.
102. Poitras, S., Avouac, J., Rossignol, M., Avouac, B., Cedraschi, C., Nordin, M. et al. (2007) A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria. Arthritis Res Ther 9: R126.
103. Pollo, F.E., Otis, J.C., Backus, S.I., Warren, R.F. and Wickiewicz, T.L. ( 2002) Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee. Am J Sports Med 30: 414-421.
104. Rab, G.T. ( 1999) The geometry of slipped capital femoral epiphysis: implications for movement, impingement, and corrective osteotomy. J Pediatr Orthop 19: 419-424.
105. Rao, V. ( 2009) Good or Useless, Medical Scans Cost the Same, http://www.nytimes.com/2009/03/02/health/02scans.html (accessed July 03, 2009).
106. Reichenbach, S., Guermazi, A., Niu, J., Neogi, T., Hunter, D.J., Roemer, F.W. et al. (2008) Prevalence of bone attrition on knee radiographs and MRI in a community-based cohort. Osteoarthritis Cartilage 16: 1005-1010.
107. Roddy, E., Zhang, W., Doherty, M., Arden, N.K., Barlow, J., Birrell, F. et al. (2005 a) Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee-the MOVE consensus. Rheumatology (Oxford) 44: 67-73.
108. Roddy, E., Zhang, W., Doherty, M., Roddy, E., Zhang, W. and Doherty, M. ( 2005b) Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis 64: 544-548.
109. Rosemann, T., Wensing, M., Joest, K., Backenstrass, M., Mahler, C. and Szecsenyi, J. ( 2006) Problems and needs for improving primary care of osteoarthritis patients: the views of patients, general practitioners and practice nurses. BMC Musculoskelet Disord 7: 48.
110. Sarzi-Puttini, P., Cimmino, M.A., Scarpa, R., Caporali, R., Parazzini, F., Zaninelli, A. et al. (2005) Do physicians treat symptomatic osteoarthritis patients properly? Results of the AMICA experience. Semin Arthritis Rheum 35: 38-42.
111. Schnitzer, T.J., Popovich, J.M., Andersson, G.B. and Andriacchi, T.P. ( 1993) Effect of piroxicam on gait in patients with osteoarthritis of the knee. Arthritis Rheum 36: 1207-1213.
112. Seedhom, B.B., Dowson, D. and Wright, V. ( 1974) Proceedings: Functions of the menisci. A preliminary study. Ann Rheum Dis 33: 111.
113. Shakoor, N. and Moisio, K. ( 2004) A biomechanical approach to musculoskeletal disease. Best Pract Res Clin Rheumatol 18: 173-186.
114. Sharma, L., Dunlop, D.D., Cahue, S., Song, J. and Hayes, K.W. ( 2003) Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med 138: 613-619.
115. Sharma, L., Hurwitz, D.E., Thonar, E.J., Sum, J.A., Lenz, M.E., Dunlop, D.D. et al. (1998) Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis. Arthritis Rheum 41: 1233-1240.
116. Sharma, L., Lou, C., Cahue, S. and Dunlop, D.D. ( 2000) The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment. Arthritis Rheum 43: 568-575.
117. Sharma, L., Song, J., Felson, D.T., Cahue, S., Shamiyeh, E. and Dunlop, D.D. ( 2001) The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 286: 188-195.
118. Shelbourne, K.D., Davis, T.J. and Klootwyk, T.E. ( 1998) The relationship between intercondylar notch width of the femur and the incidence of anterior cruciate ligament tears. A prospective study. Am J Sports Med 26: 402-408.
119. Slemenda, C., Heilman, D.K., Brandt, K.D., Katz, B.P., Mazzuca, S.A., Braunstein, E.M. et al. (1998) Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women ? Arthritis Rheum 41: 1951-1959.
120. Snow, S.W., Keret, D., Scarangella, S. and Bowen, J.R. ( 1993) Anterior impingement of the femoral head: a late phenomenon of Legg-Calve-Perthes’ disease. J Pediatr Orthop 13: 286-289.
121. Solomon, L. ( 1976) Patterns of osteoarthritis of the hip. J Bone Joint Surg Br 58: 176-183.
122. Tallon, D., Chard, J. and Dieppe, P. ( 2000) Relation between agendas of the research community and the research consumer. Lancet 355: 2037-2040.
123. Tanzer, M. and Noiseux, N. ( 2004) Osseous abnormalities and early osteoarthritis: the role of hip impingement. Clin Orthop Relat Res 429: 170-177.
124. Teichtahl, A., Wluka, A. and Cicuttini, F.M. ( 2003) Abnormal biomechanics: a precursor or result of knee osteoarthritis ? Br J Sports Med 37: 289-290.
125. Tetsworth, K. and Paley, D. ( 1994) Malalignment and degenerative arthropathy. Orthop Clin North Am 25: 367-377.
126. Todd, P.A. and Clissold, S.P. ( 1990) Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states. Drugs 40: 91-137.
127. Wolfe, M.M., Lichtenstein, D.R. and Singh, G. ( 1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Eng J Med 340: 1888-1899.
128. Woolf, S.H., Grol, R., Hutchinson, A., Eccles, M. and Grimshaw, J. ( 1999) Clinical guidelines: potential benefits, limitations, and harms of clinical guidelines. BMJ 318: 527-530.
129. Zhang, W., Moskovitz, R., Nuki, G., Abramson, S., Altman, R., Arden, N. et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16: 137-162.
130. Zhang, W., Doherty, M., Arden, N., Bannwarth, B., Bijlsma, J., Gunther, K.P. et al. (2005) EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR V Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 64: 669-681.