Intra-articular Hyaluronic Acid in Treatment of Knee Osteoarthritis: A Meta-analysis

JAMA

Volumn 290, Issue 23, 2003, Pages 3115-3121

  Lo, Grace H ^a,b   LaValley, Michael ^c   McAlindon, Timothy ^b,d   Felson, David T ^b  

^a Boston University School of Medicine ^*  (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTZAL; BIOHY; HYALURONIC ACID; PLACEBO; SUPLASYN;

CLINICAL TRIAL; COCHRANE LIBRARY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FOOD AND DRUG ADMINISTRATION; HUMAN; KNEE OSTEOARTHRITIS; KNEE PAIN; MEDLINE; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STATISTICAL ANALYSIS; TOTAL KNEE REPLACEMENT;

EID: 0347380153     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.290.23.3115     Document Type: Review

References (38)

1. Mazieres B, Bannwarth B, Dougados M, Lequesne M. EULAR recommendations for the management of knee osteoarthritis: report of a taskforce of the Standing Committee for International Clinical Studies Including Therapeutic Trials. Joint Bone Spine. 2001;68:231-240.
2. Pendleton A, Arden N, Dougados M, et al. EULAR recommendations for the management of knee osteoarthritis: report of a taskforce of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2000;59:936-944.
3. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43:1905-1915.
4. Felson DT, Anderson JJ, Hyaluronate sodium injections for osteoarthritis: hope, hype, and hard truths. Arch Intern Med, 2002;162:245-247.
5. Brandt KD, Smith GN Jr, Simon LS. Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: what is the evidence? Arthritis Rheum. 2000;43:1192-1203.
6. Synvisc-Hylan G-F 20 [package insert]. Ridgefield, NJ: Biometrics Inc; 2000.
7. Altman R, Brandt K, Hochberg M, et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a taskforce of the Osteoarthritis Research Society: results from a workshop. Osteoarthritis Cartilage. 1996;4:217-243.
8. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed, Hillsdale, NJ: L Erlbaum Associates; 1988:xxi, 567.
9. Felson DT. The verdict favors nonsteroidal antiinflammatory drugs for treatment of osteoarthritis and a plea for more evidence on other treatments. Arthritis Rheum. 2001;44:1477-1180.
10. Liang MH, Larson MG, Cullen KE, Schwartz JA. Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research. Arthritis Rheum. 1985;28:542-547.
11. Roos EM, Nilsdotter AK, Toksvig-Larsen S, Patient expectations suggest additional outcomes in total knee replacement [abstract]. Arthritis Rheum. 2002;46(suppl):9.
12. Dixon AS, Jacoby RK, Berry H, Hamilton EB. Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee. Curr Med Res Opin. 1988;11:205-213.
13. Russell IJ, Michalek JE, Lawrence VA, Lessard JA, Briggs BT, May GS. A randomized, placebo and no-intervention controlled, trial of intra-articular 1% sodium hyaluronate in the treatment of knee osteoarthritis [abstract]. Arthritis Rheum. 1992;35(suppl):9.
14. Dougados M, Nguyen M, Listrat V, Amor B. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial. Osteoarthritis Cartilage 1993;1:97-103.
15. Puhl W, Bernau A, Greiling H. Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study. Osteoarthritis Cartilage. 1993;1:233-241.
16. Dahlberg L, Lohmander LS, Ryd L. Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain: a one-year double-blind, placebo-controlled study. Arthritis Rheum. 1994;37:521-528.
17. Creamer P, Sharif M, George E, et al. Intraarticular hyaluronic acid in osteoarthritis of the knee: an investigation into mechanisms of action. Osteoarthritis Cartilage. 1994;2:133-140.
18. Henderson EB, Smith EC, Pegley F, Blake Dr. Intraarticular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy. Ann Rheum Dis. 1994;53:529-534.
19. Cohen MA, Shiroky JB, Ballechey ML, Neville C, Esdaile JM. Double-blind randomized trial of Intraarticular Hyaluronate in the treatment of osteoarthritis of the knee. Arthritis Rheum. 1994;34(suppl):6.
20. Scale D, Wobig M, Wolpert W. Viscosupplementation of osteoarthritic knees with hylan: a treatment schedule study. Curr Therapeut Res. 1994;55:220-232.
21. Corrado E, Peluso GF, Gigliotti S. The effects of intra-articular administration of hyaluronic acid on osteoarthritis of the knee: a clinical study with immunological and biochemical evaluations. Eur J Rheumatol Inflamm. 1995;15:47-56.
22. Sala SF, Miguel RE. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: a short-term study. Eur J Rheumatol Inflamm. 1995;15:33-38.
23. Carrabba M, Paresce E, Angelini M, Re KA, Torchiana EEM, Perbellini A. The safety and efficacy of different dose schedules of hyaluronic acid in the treatment of painful osteoarthritis of the knee with joint effusion. Eur J Rheumatol Inflamm. 1995;15:25-31.
24. Lohmander LS, Dalen N, Englund G, et al, for the Hyaluronan Multicentre Trial Group. Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Ann Rheum Dis. 1996;55:424-431.
25. Wobig M, Dickhut A, Maier R, Vetter G, et al. Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther. 1998;20:410-423.
26. Altman RD, Moskowitz R, for the Hyalgan Study Group. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. J Rheumatol. 1998;25:2203-2212.
27. Huskisson EC, Donnelly S. Hyaluronic acid in the treatment of osteoarthritis of the knee. Rheumatology (Oxford). 1999;38:602-607.
28. Brandt KD, Block JA, Michalski JP, Moreland LW, Caldwell JR, Lavin PT, for the ORTHOVISC Study Group. Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. Clin Orthop. 2001;385:130-143.
29. Tamir E, Robinson D, Koren R, Agar G, Halperin N. Intra-articular hyaluronan injections for the treatment of osteoarthritis of the knee: a randomized, double-blind placebo controlled study. Clin Exp Rheumatol. 2001;19:265-270.
30. Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med. 2002;162:292-298.
31. Karlsson J, Sjogren LS, Lohmander LS. Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis: a controlled, randomized, double-blind, parallel-design multicentre study. Rheumatology (Oxford). 2002;41:1240-1248.
32. Pham T, Le Hananff A, Ravaud P. Lack of symptomatic and structural efficacy of a new hyaluroninc acid compound, (NRD101), when compared to diacerein and placebo in a one year controlled study in symptomatic knee osteoarthritis [abstract]. Artritis Rheum. 2003;48(suppl):9.
33. Jubb R, Piva S, Beinat L, Dacre I, Gishen P. A one-year, randomised, placebo (saline) controlled clinical trial of 500-730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee. Int J Clin Pract. 2003;57:467-474.
34. Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000;53:1119-1129.
35. Lexchin J, Bero LA, Djulbegovic B, Clark O. Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ. 2003;326:1167-1170.
36. Kirwan J. Is there a place for intra-articular hyaluronate in osteoarthritis of the knee? Knee. 2001;8:93-101.
37. Aviad AD, Houpt JB. The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it? J Rheumatol. 1994;21:297-301.
38. Allard S, O'Regan M. The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee: a comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan. Clin Ther. 2000;22:792-795.