메뉴 건너뛰기




Volumn 274, Issue 1, 2016, Pages 270-280

Injury site-specific targeting of complement inhibitors for treating stroke

Author keywords

complement system; inflammation; stroke; stroke therapeutics; tissue targeting

Indexed keywords

COMPLEMENT; COMPLEMENT INHIBITOR; CR2 CD59; CR2 CRRY; CR2 FH; CRLG CD59; REGULATOR PROTEIN; SCFV CRRY; SCR1SLE; UNCLASSIFIED DRUG;

EID: 84992468368     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12470     Document Type: Review
Times cited : (41)

References (85)
  • 1
    • 84969376984 scopus 로고    scopus 로고
    • Executive Summary: Heart Disease and Stroke Statistics—2016 Update A Report from the American Heart Association
    • Mozaffarian D, Benjamin EJ, Go AS, et al. Executive Summary: Heart Disease and Stroke Statistics—2016 Update A Report from the American Heart Association. Circulation. 2016;133:447–454.
    • (2016) Circulation , vol.133 , pp. 447-454
    • Mozaffarian, D.1    Benjamin, E.J.2    Go, A.S.3
  • 3
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    • Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–2223.
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.1    Vos, T.2    Lozano, R.3
  • 4
    • 79961209219 scopus 로고    scopus 로고
    • Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead
    • Towfighi A, Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke. 2011;42:2351–2355.
    • (2011) Stroke , vol.42 , pp. 2351-2355
    • Towfighi, A.1    Saver, J.L.2
  • 5
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333:1581–1587.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 6
    • 0035942340 scopus 로고    scopus 로고
    • Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    • Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility Neurology. 2001;56:1015–1020.
    • (2001) Neurology , vol.56 , pp. 1015-1020
    • Barber, P.A.1    Zhang, J.2    Demchuk, A.M.3    Hill, M.D.4    Buchan, A.M.5
  • 7
    • 0038304591 scopus 로고    scopus 로고
    • Frequency of thrombolytic therapy in patients with acute ischemic stroke and the risk of in-hospital mortality: the German Stroke Registers Study Group
    • Heuschmann PU, Berger K, Misselwitz B, et al. Frequency of thrombolytic therapy in patients with acute ischemic stroke and the risk of in-hospital mortality: the German Stroke Registers Study Group. Stroke. 2003;34:1106–1113.
    • (2003) Stroke , vol.34 , pp. 1106-1113
    • Heuschmann, P.U.1    Berger, K.2    Misselwitz, B.3
  • 8
    • 67650071086 scopus 로고    scopus 로고
    • Motor recovery after stroke: a systematic review
    • Langhorne P, Coupar F, Pollock A. Motor recovery after stroke: a systematic review. Lancet Neurol. 2009;8:741–754.
    • (2009) Lancet Neurol , vol.8 , pp. 741-754
    • Langhorne, P.1    Coupar, F.2    Pollock, A.3
  • 9
    • 70450267518 scopus 로고    scopus 로고
    • Plasticity during stroke recovery: from synapse to behaviour
    • Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10:861–872.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 861-872
    • Murphy, T.H.1    Corbett, D.2
  • 10
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17:796–808.
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 11
    • 0029910943 scopus 로고    scopus 로고
    • Complement activation in the central nervous system following blood-brain barrier damage in man
    • Lindsberg PJ, Öhman J, Lehto T, et al. Complement activation in the central nervous system following blood-brain barrier damage in man. Ann Neurol. 1996;40:587–596.
    • (1996) Ann Neurol , vol.40 , pp. 587-596
    • Lindsberg, P.J.1    Öhman, J.2    Lehto, T.3
  • 13
    • 84882627221 scopus 로고    scopus 로고
    • Cardioembolic and small vessel disease stroke show differences in associations between systemic C3 levels and outcome
    • Stokowska A, Olsson S, Holmegaard L, et al. Cardioembolic and small vessel disease stroke show differences in associations between systemic C3 levels and outcome. PLoS ONE. 2013;8:e72133.
    • (2013) PLoS ONE , vol.8
    • Stokowska, A.1    Olsson, S.2    Holmegaard, L.3
  • 15
    • 0035377582 scopus 로고    scopus 로고
    • Systemic complement activation in ischemic stroke
    • Di Napoli M. Systemic complement activation in ischemic stroke. Stroke. 2001;32:1443–1448.
    • (2001) Stroke , vol.32 , pp. 1443-1448
    • Di Napoli, M.1
  • 16
    • 58149333274 scopus 로고    scopus 로고
    • Platelet C4d is associated with acute ischemic stroke and stroke severity
    • Mehta N, Uchino K, Fakhran S, et al. Platelet C4d is associated with acute ischemic stroke and stroke severity. Stroke. 2008;39:3236–3241.
    • (2008) Stroke , vol.39 , pp. 3236-3241
    • Mehta, N.1    Uchino, K.2    Fakhran, S.3
  • 17
    • 84897120707 scopus 로고    scopus 로고
    • Prognostic value of mannose-binding lectin: 90-day outcome in patients with acute ischemic stroke
    • Zhang ZG, Wang C, Wang J, et al. Prognostic value of mannose-binding lectin: 90-day outcome in patients with acute ischemic stroke. Mol Neurobiol. 2015;51:230–239.
    • (2015) Mol Neurobiol , vol.51 , pp. 230-239
    • Zhang, Z.G.1    Wang, C.2    Wang, J.3
  • 18
    • 84939885619 scopus 로고    scopus 로고
    • Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months
    • Zhang B, Yang N, Gao C. Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months. J Thromb Thrombolysis. 2015;39:209–214.
    • (2015) J Thromb Thrombolysis , vol.39 , pp. 209-214
    • Zhang, B.1    Yang, N.2    Gao, C.3
  • 19
  • 21
    • 84934442096 scopus 로고    scopus 로고
    • CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation
    • Holers VM, Rohrer B, Tomlinson S. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Adv Exp Med Biol. 2013;735:137–154.
    • (2013) Adv Exp Med Biol , vol.735 , pp. 137-154
    • Holers, V.M.1    Rohrer, B.2    Tomlinson, S.3
  • 22
    • 58149349888 scopus 로고    scopus 로고
    • Interaction between the coagulation and complement system
    • Amara U, Rittirsch D, Flierl M, et al. Interaction between the coagulation and complement system. Adv Exp Med Biol. 2008;632:71–79.
    • (2008) Adv Exp Med Biol , vol.632 , pp. 71-79
    • Amara, U.1    Rittirsch, D.2    Flierl, M.3
  • 23
    • 33744987414 scopus 로고    scopus 로고
    • Generation of C5a in the absence of C3: a new complement activation pathway
    • Huber-Lang M, Sarma JV, Zetoune FS, et al. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med. 2006;12:682–687.
    • (2006) Nat Med , vol.12 , pp. 682-687
    • Huber-Lang, M.1    Sarma, J.V.2    Zetoune, F.S.3
  • 24
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol. 2009;9:729–740.
    • (2009) Nat Rev Immunol , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2
  • 25
    • 84863011135 scopus 로고    scopus 로고
    • Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice
    • Elvington A, Atkinson C, Kulik L, et al. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J Immunol. 2012;188:1460–1468.
    • (2012) J Immunol , vol.188 , pp. 1460-1468
    • Elvington, A.1    Atkinson, C.2    Kulik, L.3
  • 26
    • 84929353534 scopus 로고    scopus 로고
    • Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury
    • Atkinson C, Qiao F, Yang X, et al. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015;131:1171–1180.
    • (2015) Circulation , vol.131 , pp. 1171-1180
    • Atkinson, C.1    Qiao, F.2    Yang, X.3
  • 27
    • 66949175208 scopus 로고    scopus 로고
    • Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury
    • Kulik L, Fleming SD, Moratz C, et al. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol. 2009;182:5363–5373.
    • (2009) J Immunol , vol.182 , pp. 5363-5373
    • Kulik, L.1    Fleming, S.D.2    Moratz, C.3
  • 28
    • 0030014528 scopus 로고    scopus 로고
    • Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement
    • Weiser MR, Williams JP, Moore FD, et al. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med. 1996;183:2343–2348.
    • (1996) J Exp Med , vol.183 , pp. 2343-2348
    • Weiser, M.R.1    Williams, J.P.2    Moore, F.D.3
  • 29
    • 0035908925 scopus 로고    scopus 로고
    • Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury
    • Jordan JE, Montalto MC, Stahl GL. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Circulation. 2001;104:1413–1418.
    • (2001) Circulation , vol.104 , pp. 1413-1418
    • Jordan, J.E.1    Montalto, M.C.2    Stahl, G.L.3
  • 30
    • 73949103664 scopus 로고    scopus 로고
    • C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production
    • Fraser DA, Pisalyaput K, Tenner AJ. C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J Neurochem. 2010;112:733–743.
    • (2010) J Neurochem , vol.112 , pp. 733-743
    • Fraser, D.A.1    Pisalyaput, K.2    Tenner, A.J.3
  • 31
    • 0028880756 scopus 로고
    • Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor
    • Tenner AJ, Robinson SL, Ezekowitz RA. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor. Immunity. 1995;3:485–493.
    • (1995) Immunity , vol.3 , pp. 485-493
    • Tenner, A.J.1    Robinson, S.L.2    Ezekowitz, R.A.3
  • 32
    • 33644541441 scopus 로고    scopus 로고
    • Evidence that complement protein C1q interacts with C-reactive protein through its globular head region
    • McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE, Roos A. Evidence that complement protein C1q interacts with C-reactive protein through its globular head region. J Immunol. 2006;176:2950–2957.
    • (2006) J Immunol , vol.176 , pp. 2950-2957
    • McGrath, F.D.1    Brouwer, M.C.2    Arlaud, G.J.3    Daha, M.R.4    Hack, C.E.5    Roos, A.6
  • 33
    • 14244266540 scopus 로고    scopus 로고
    • Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation
    • Kuraya M, Ming Z, Liu X, Matsushita M, Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology. 2005;209:689–697.
    • (2005) Immunobiology , vol.209 , pp. 689-697
    • Kuraya, M.1    Ming, Z.2    Liu, X.3    Matsushita, M.4    Fujita, T.5
  • 34
    • 84866491168 scopus 로고    scopus 로고
    • Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia
    • Orsini F, Villa P, Parrella S, et al. Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia. Circulation. 2012;126:1484–1494.
    • (2012) Circulation , vol.126 , pp. 1484-1494
    • Orsini, F.1    Villa, P.2    Parrella, S.3
  • 35
    • 33747598070 scopus 로고    scopus 로고
    • Complement component C3 mediates inflammatory injury following focal cerebral ischemia
    • Mocco J, Mack WJ, Ducruet AF, et al. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res. 2006;99:209–217.
    • (2006) Circ Res , vol.99 , pp. 209-217
    • Mocco, J.1    Mack, W.J.2    Ducruet, A.F.3
  • 36
    • 84895185081 scopus 로고    scopus 로고
    • The relationship between serum mannose-binding lectin levels and acute ischemic stroke risk
    • Wang ZY, Sun ZR, Zhang LM. The relationship between serum mannose-binding lectin levels and acute ischemic stroke risk. Neurochem Res. 2014;39:248–253.
    • (2014) Neurochem Res , vol.39 , pp. 248-253
    • Wang, Z.Y.1    Sun, Z.R.2    Zhang, L.M.3
  • 37
    • 79959359209 scopus 로고    scopus 로고
    • Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients
    • Osthoff M, Katan M, Fluri F, et al. Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients. PLoS ONE. 2011;6:e21338.
    • (2011) PLoS ONE , vol.6
    • Osthoff, M.1    Katan, M.2    Fluri, F.3
  • 38
    • 79951717772 scopus 로고    scopus 로고
    • The contribution of mannose binding lectin to reperfusion injury after ischemic stroke
    • Morrison H, Frye J, Davis-Gorman G, et al. The contribution of mannose binding lectin to reperfusion injury after ischemic stroke. Curr Neurovasc Res. 2011;8:52–63.
    • (2011) Curr Neurovasc Res , vol.8 , pp. 52-63
    • Morrison, H.1    Frye, J.2    Davis-Gorman, G.3
  • 39
    • 84954427988 scopus 로고    scopus 로고
    • Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
    • Zangari R, Zanier ER, Torgano G, et al. Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. J Neuroinflammation. 2016;13:16.
    • (2016) J Neuroinflammation , vol.13 , pp. 16
    • Zangari, R.1    Zanier, E.R.2    Torgano, G.3
  • 40
    • 77949417477 scopus 로고    scopus 로고
    • Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
    • Cervera A, Planas AM, Justicia C, et al. Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS ONE. 2010;5:e8433.
    • (2010) PLoS ONE , vol.5
    • Cervera, A.1    Planas, A.M.2    Justicia, C.3
  • 41
    • 84857193396 scopus 로고    scopus 로고
    • Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
    • Fust G, Munthe-Fog L, Illes Z, et al. Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke. J Neuroinflammation. 2011;8:185.
    • (2011) J Neuroinflammation , vol.8 , pp. 185
    • Fust, G.1    Munthe-Fog, L.2    Illes, Z.3
  • 42
    • 84867910274 scopus 로고    scopus 로고
    • The alternative complement pathway propagates inflammation and injury in murine ischemic stroke
    • Elvington A, Atkinson C, Zhu H, et al. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012;189:4640–4647.
    • (2012) J Immunol , vol.189 , pp. 4640-4647
    • Elvington, A.1    Atkinson, C.2    Zhu, H.3
  • 43
    • 84897859634 scopus 로고    scopus 로고
    • Microglial phagocytosis of live neurons
    • Brown GC, Neher JJ. Microglial phagocytosis of live neurons. Nat Rev Neurosci. 2014;15:209–216.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 209-216
    • Brown, G.C.1    Neher, J.J.2
  • 44
    • 84860338445 scopus 로고    scopus 로고
    • The complement system: an unexpected role in synaptic pruning during development and disease
    • Stephan AH, Barres BA, Stevens B. The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci. 2012;35:369–389.
    • (2012) Annu Rev Neurosci , vol.35 , pp. 369-389
    • Stephan, A.H.1    Barres, B.A.2    Stevens, B.3
  • 45
    • 77950187449 scopus 로고    scopus 로고
    • Crosstalk pathways between Toll-like receptors and the complement system
    • Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31:154–163.
    • (2010) Trends Immunol , vol.31 , pp. 154-163
    • Hajishengallis, G.1    Lambris, J.D.2
  • 46
    • 79952751974 scopus 로고    scopus 로고
    • Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis
    • Moriyama M, Fukuhara T, Britschgi M, et al. Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J Neurosci. 2011;31:3981–3989.
    • (2011) J Neurosci , vol.31 , pp. 3981-3989
    • Moriyama, M.1    Fukuhara, T.2    Britschgi, M.3
  • 47
    • 84951994142 scopus 로고    scopus 로고
    • Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement
    • Alawieh A, Elvington AF, Zhu H, et al. Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement. J Neuroinflammation. 2015;12:247.
    • (2015) J Neuroinflammation , vol.12 , pp. 247
    • Alawieh, A.1    Elvington, A.F.2    Zhu, H.3
  • 48
    • 33750808896 scopus 로고    scopus 로고
    • Complement-dependent P-selectin expression and injury following ischemic stroke
    • Atkinson C, Zhu H, Qiao F, et al. Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol. 2006;177:7266–7274.
    • (2006) J Immunol , vol.177 , pp. 7266-7274
    • Atkinson, C.1    Zhu, H.2    Qiao, F.3
  • 49
    • 42549162344 scopus 로고    scopus 로고
    • C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent
    • Ducruet AF, Hassid BG, Mack WJ, et al. C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. J Cereb Blood Flow Metab. 2008;28:1048–1058.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1048-1058
    • Ducruet, A.F.1    Hassid, B.G.2    Mack, W.J.3
  • 50
    • 69749116356 scopus 로고    scopus 로고
    • Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage
    • Garrett MC, Otten ML, Starke RM, et al. Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage. Brain Res. 2009;1298:171–177.
    • (2009) Brain Res , vol.1298 , pp. 171-177
    • Garrett, M.C.1    Otten, M.L.2    Starke, R.M.3
  • 51
    • 33846232316 scopus 로고    scopus 로고
    • Expression of complement regulators and receptors on human NT2-N neurons–effect of hypoxia and reoxygenation
    • Pedersen ED, Frøyland E, Kvissel AK, et al. Expression of complement regulators and receptors on human NT2-N neurons–effect of hypoxia and reoxygenation. Mol Immunol. 2007;44:2459–2468.
    • (2007) Mol Immunol , vol.44 , pp. 2459-2468
    • Pedersen, E.D.1    Frøyland, E.2    Kvissel, A.K.3
  • 52
    • 77950413671 scopus 로고    scopus 로고
    • Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice
    • Harhausen D, Khojasteh U, Stahel PF, et al. Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J Neuroinflammation. 2010;7:15.
    • (2010) J Neuroinflammation , vol.7 , pp. 15
    • Harhausen, D.1    Khojasteh, U.2    Stahel, P.F.3
  • 53
    • 0033921540 scopus 로고    scopus 로고
    • Complement components of the innate immune system in health and disease in the CNS
    • Gasque P, Dean YD, McGreal EP, VanBeek J, Morgan BP. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology. 2000;49:171–186.
    • (2000) Immunopharmacology , vol.49 , pp. 171-186
    • Gasque, P.1    Dean, Y.D.2    McGreal, E.P.3    VanBeek, J.4    Morgan, B.P.5
  • 54
    • 77955883153 scopus 로고    scopus 로고
    • Complement: a key system for immune surveillance and homeostasis
    • Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11:785–797.
    • (2010) Nat Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 55
    • 0029053689 scopus 로고
    • Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines
    • Gasque P, Fontaine M, Morgan BP. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J Immunol. 1995;154:4726–4733.
    • (1995) J Immunol , vol.154 , pp. 4726-4733
    • Gasque, P.1    Fontaine, M.2    Morgan, B.P.3
  • 56
    • 0023226359 scopus 로고
    • Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation
    • Levi-Strauss M, Mallat M. Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation. J Immunol. 1987;139:2361–2366.
    • (1987) J Immunol , vol.139 , pp. 2361-2366
    • Levi-Strauss, M.1    Mallat, M.2
  • 57
    • 0030828544 scopus 로고    scopus 로고
    • Neurons express proteins of the classical complement pathway in Alzheimer disease
    • Terai K, Walker DG, McGeer EG, McGeer PL. Neurons express proteins of the classical complement pathway in Alzheimer disease. Brain Res. 1997;769:385–390.
    • (1997) Brain Res , vol.769 , pp. 385-390
    • Terai, K.1    Walker, D.G.2    McGeer, E.G.3    McGeer, P.L.4
  • 58
    • 0029799125 scopus 로고    scopus 로고
    • Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes
    • Gasque P, Morgan BP. Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes. Immunology. 1996;89:338–347.
    • (1996) Immunology , vol.89 , pp. 338-347
    • Gasque, P.1    Morgan, B.P.2
  • 59
    • 33645079378 scopus 로고    scopus 로고
    • Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis
    • Cole DS, Hughes TR, Gasque P, Morgan BP. Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis. Mol Immunol. 2006;43:1953–1964.
    • (2006) Mol Immunol , vol.43 , pp. 1953-1964
    • Cole, D.S.1    Hughes, T.R.2    Gasque, P.3    Morgan, B.P.4
  • 60
    • 33645309347 scopus 로고    scopus 로고
    • Complement: a novel factor in basal and ischemia-induced neurogenesis
    • Rahpeymai Y, Hietala MA, Wilhelmsson U, et al. Complement: a novel factor in basal and ischemia-induced neurogenesis. EMBO J. 2006;25:1364–1374.
    • (2006) EMBO J , vol.25 , pp. 1364-1374
    • Rahpeymai, Y.1    Hietala, M.A.2    Wilhelmsson, U.3
  • 61
    • 0033562337 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity
    • Osaka H, Mukherjee P, Aisen PS, Pasinetti GM. Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity. J Cell Biochem. 1999;73:303–311.
    • (1999) J Cell Biochem , vol.73 , pp. 303-311
    • Osaka, H.1    Mukherjee, P.2    Aisen, P.S.3    Pasinetti, G.M.4
  • 62
    • 0035847643 scopus 로고    scopus 로고
    • Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death
    • van Beek J, Nicole O, Ali C, et al. Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death. NeuroReport. 2001;12:289–293.
    • (2001) NeuroReport , vol.12 , pp. 289-293
    • van Beek, J.1    Nicole, O.2    Ali, C.3
  • 63
    • 33644516274 scopus 로고    scopus 로고
    • C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP
    • Cudrici C, Niculescu F, Jensen T, et al. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. J Immunol. 2006;176:3173–3180.
    • (2006) J Immunol , vol.176 , pp. 3173-3180
    • Cudrici, C.1    Niculescu, F.2    Jensen, T.3
  • 64
    • 85047692710 scopus 로고    scopus 로고
    • Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation
    • Song H, He C, Knaak C, Guthridge JM, Holers VM, Tomlinson S. Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. J Clin Invest. 2003;111:1875–1885.
    • (2003) J Clin Invest , vol.111 , pp. 1875-1885
    • Song, H.1    He, C.2    Knaak, C.3    Guthridge, J.M.4    Holers, V.M.5    Tomlinson, S.6
  • 65
    • 24644487357 scopus 로고    scopus 로고
    • Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection
    • Atkinson C, Song H, Lu B, et al. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J Clin Invest. 2005;115:2444–2453.
    • (2005) J Clin Invest , vol.115 , pp. 2444-2453
    • Atkinson, C.1    Song, H.2    Lu, B.3
  • 66
    • 71849106514 scopus 로고    scopus 로고
    • A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury
    • Huang Y, Qiao F, Atkinson C, Holers VM, Tomlinson S. A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury. J Immunol. 2008;181:8068–8076.
    • (2008) J Immunol , vol.181 , pp. 8068-8076
    • Huang, Y.1    Qiao, F.2    Atkinson, C.3    Holers, V.M.4    Tomlinson, S.5
  • 67
    • 33644863561 scopus 로고    scopus 로고
    • Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials?
    • Vargas M, Horcajada JP, Obash V, et al. Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials? Stroke. 2006;37:461–465.
    • (2006) Stroke , vol.37 , pp. 461-465
    • Vargas, M.1    Horcajada, J.P.2    Obash, V.3
  • 69
    • 84867567497 scopus 로고    scopus 로고
    • Breaking the barrier in stroke: what should we know? A mini-review
    • Borlongan CV, Rodrigues AA Jr, Oliveira MC. Breaking the barrier in stroke: what should we know? A mini-review Curr Pharm Des. 2012;18:3615–3623.
    • (2012) Curr Pharm Des , vol.18 , pp. 3615-3623
    • Borlongan, C.V.1    Rodrigues, A.A.2    Oliveira, M.C.3
  • 70
    • 0037532616 scopus 로고    scopus 로고
    • An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
    • Emsley HC, Smith CJ, Gavin CM, et al. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol. 2003;139:93–101.
    • (2003) J Neuroimmunol , vol.139 , pp. 93-101
    • Emsley, H.C.1    Smith, C.J.2    Gavin, C.M.3
  • 72
    • 0034114249 scopus 로고    scopus 로고
    • Serum C-reactive protein and self-reported stroke: findings from the Third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH. Serum C-reactive protein and self-reported stroke: findings from the Third National Health and Nutrition Examination Survey. Arterioscler Thromb Vasc Biol. 2000;20:1052–1056.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1052-1056
    • Ford, E.S.1    Giles, W.H.2
  • 73
    • 2642600862 scopus 로고
    • Covalent binding and hemolytic activity of complement proteins
    • Law SK, Lichtenberg NA, Levine RP. Covalent binding and hemolytic activity of complement proteins. Proc Natl Acad Sci USA. 1980;77:7194–7198.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 7194-7198
    • Law, S.K.1    Lichtenberg, N.A.2    Levine, R.P.3
  • 74
    • 84906545577 scopus 로고    scopus 로고
    • Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy
    • Marshall KM, He S, Zhong Z, Atkinson C, Tomlinson S. Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. J Exp Med. 2014;211:1793–1805.
    • (2014) J Exp Med , vol.211 , pp. 1793-1805
    • Marshall, K.M.1    He, S.2    Zhong, Z.3    Atkinson, C.4    Tomlinson, S.5
  • 75
    • 79953729061 scopus 로고    scopus 로고
    • The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice
    • Sekine H, Kinser TTH, Qiao F, et al. The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice. Arthritis Rheum. 2011;63:1076–1085.
    • (2011) Arthritis Rheum , vol.63 , pp. 1076-1085
    • Sekine, H.1    Kinser, T.T.H.2    Qiao, F.3
  • 76
    • 84947461464 scopus 로고    scopus 로고
    • An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice
    • Ruseva MM, Ramaglia V, Morgan BP, Harris CL. An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice. Proc Natl Acad Sci USA. 2015;112:14319–14324.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 14319-14324
    • Ruseva, M.M.1    Ramaglia, V.2    Morgan, B.P.3    Harris, C.L.4
  • 77
    • 0033597941 scopus 로고    scopus 로고
    • Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein
    • Huang J, Kim LJ, Mealey R, et al. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science. 1999;285:595–599.
    • (1999) Science , vol.285 , pp. 595-599
    • Huang, J.1    Kim, L.J.2    Mealey, R.3
  • 78
    • 0037076863 scopus 로고    scopus 로고
    • The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats
    • Imm MD, Feldhoff PW, Feldhoff RC, Lassiter HA. The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats. Neurosci Lett. 2002;325:175–178.
    • (2002) Neurosci Lett , vol.325 , pp. 175-178
    • Imm, M.D.1    Feldhoff, P.W.2    Feldhoff, R.C.3    Lassiter, H.A.4
  • 79
    • 35748936795 scopus 로고    scopus 로고
    • Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke
    • Ducruet AF, Mocco J, Mack WJ, et al. Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke. J Med Primatol. 2007;36:375–380.
    • (2007) J Med Primatol , vol.36 , pp. 375-380
    • Ducruet, A.F.1    Mocco, J.2    Mack, W.J.3
  • 80
    • 84899963564 scopus 로고    scopus 로고
    • Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice
    • de la Rosa X, Cervera A, Kristoffersen AK, et al. Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice. Stroke. 2014;45:1453–1459.
    • (2014) Stroke , vol.45 , pp. 1453-1459
    • de la Rosa, X.1    Cervera, A.2    Kristoffersen, A.K.3
  • 81
    • 83355169620 scopus 로고    scopus 로고
    • The neuroprotective effect of genetic mannose-binding lectin deficiency is not sustained in the sub-acute phase of stroke
    • Ducruet AF, Sosunov SA, Zacharia BE, et al. The neuroprotective effect of genetic mannose-binding lectin deficiency is not sustained in the sub-acute phase of stroke. Transl Stroke Res. 2011;2:588–599.
    • (2011) Transl Stroke Res , vol.2 , pp. 588-599
    • Ducruet, A.F.1    Sosunov, S.A.2    Zacharia, B.E.3
  • 82
    • 72849120050 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells
    • Shinjyo N, Stahlberg A, Dragunow M, Pekny M, Pekna M. Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells. 2009;27:2824–2832.
    • (2009) Stem Cells , vol.27 , pp. 2824-2832
    • Shinjyo, N.1    Stahlberg, A.2    Dragunow, M.3    Pekny, M.4    Pekna, M.5
  • 83
    • 1942437373 scopus 로고    scopus 로고
    • The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q
    • De Simoni MG, Rossi E, Storini C, Pizzimenti S, Echart C, Bergamaschini L. The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q. Am J Pathol. 2004;164:1857–1863.
    • (2004) Am J Pathol , vol.164 , pp. 1857-1863
    • De Simoni, M.G.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Echart, C.5    Bergamaschini, L.6
  • 84
    • 17444370178 scopus 로고    scopus 로고
    • C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation
    • Storini C, Rossi E, Marrella V, et al. C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation. Neurobiol Dis. 2005;19:10–17.
    • (2005) Neurobiol Dis , vol.19 , pp. 10-17
    • Storini, C.1    Rossi, E.2    Marrella, V.3
  • 85
    • 33746025371 scopus 로고    scopus 로고
    • Role of complement component C5 in cerebral ischemia/reperfusion injury
    • Costa C, Zhao L, Shen Y, et al. Role of complement component C5 in cerebral ischemia/reperfusion injury. Brain Res. 2006;1100:142–151.
    • (2006) Brain Res , vol.1100 , pp. 142-151
    • Costa, C.1    Zhao, L.2    Shen, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.