Commercial vaccines provide limited protection to NADC30-like PRRSV infection

Vaccine

Volumn 34, Issue 46, 2016, Pages 5540-5545

  Bai, Xiaofei ^b   Wang, Yuzhou ^b   Xu, Xin ^b   Sun, Zhe ^b   Xiao, Yan ^b   Ji, Guobiao ^b   Li, Yingying ^b   Tan, Feifei ^b   Li, Xiangdong ^b   Tian, Kegong ^a,b,c  

^a HENAN AGRICULTURAL UNIVERSITY   (China)

^b National Research Center for Veterinary Medicine   (China)

^c OIE Reference Laboratory for Porcine Respiratory Syndrome/National Veterinary Diagnostic Laboratory   (China)

Author keywords

Commercial PRRSV vaccines; NADC30 like PRRSV; Vaccine efficacy

Indexed keywords

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE; LIVE VACCINE; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CHINA; CONTROLLED STUDY; COUGHING; DIARRHEA; DRUG EFFICACY; DYSPNEA; FEVER; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INFECTION PREVENTION; LUNG; LUNG LESION; LYMPH NODE; LYMPHOID TISSUE; NONHUMAN; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; TACHYPNEA; TONSIL; VIREMIA; VIRUS LOAD; VIRUS STRAIN; WEIGHT GAIN; ANIMAL; BLOOD; EPIDEMIC; EVALUATION STUDY; IMMUNOLOGY; ISOLATION AND PURIFICATION; PALATINE TONSIL; PATHOGENICITY; PATHOLOGY; VACCINATION; VETERINARY; VIROLOGY;

ANIMALS; ANTIBODIES, VIRAL; CHINA; DISEASE OUTBREAKS; LUNG; PALATINE TONSIL; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUS SCROFA; SWINE; VACCINATION; VACCINES, ATTENUATED; VIRAL VACCINES; VIREMIA;

EID: 84992391512     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2016.09.048     Document Type: Article

References (15)

1. [1] Renukaradhya, G.J., Meng, X.J., Calvert, J.G., Roof, M., Lager, K.M., Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction. Vaccine 33 (2015), 4069–4080.
2. [2] Loving, C.L., Osorio, F.A., Murtaugh, M.P., Zuckermann, F.A., Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 167 (2015), 1–14.
3. [3] Karniychuk, U.U., Geldhof, M., Vanhee, M., Van Doorsselaere, J., Saveleva, T.A., Nauwynck, H.J., Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate. BMC Veter Res, 6, 2010, 30.
4. [4] Brar, M.S., Shi, M., Murtaugh, M.P., Leung, F.C., Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus. J General Virol 96 (2015), 1570–1580.
5. [5] Sun, Z., Wang, J., Bai, X., Ji, G., Yan, H., Li, Y., et al. Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus. Arch Virol 161 (2016), 2257–2261.
6. [6] Zhao, K., Ye, C., Chang, X.B., Jiang, C.G., Wang, S.J., Cai, X.H., et al. Importation and recombination are responsible for the latest emergence of highly pathogenic porcine reproductive and respiratory syndrome virus in China. J Virol 89 (2015), 10712–10716.
7. [7] Zhou, L., Wang, Z., Ding, Y., Ge, X., Guo, X., Yang, H., NADC30-like strain of porcine reproductive and respiratory syndrome virus, China. Emerg Infect Dis 21 (2015), 2256–2257.
8. [8] Tian, K., Yu, X., Zhao, T., Feng, Y., Cao, Z., Wang, C., et al. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE, 2, 2007, e526.
9. [9] Zhang, C., Guo, L., Jia, X., Wang, T., Wang, J., Sun, Z., et al. Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets. Vaccine 33 (2015), 2432–2437.
10. [10] Lunney, J.K., Fang, Y., Ladinig, A., Chen, N., Li, Y., Rowland, B., et al. Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system. Annu Rev Anim Biosci 4 (2016), 129–154.
11. [11] Li, C., Zhuang, J., Wang, J., Han, L., Sun, Z., Xiao, Y., et al. Outbreak investigation of NADC30-like PRRSV in South-East China. Transbound Emerg Dis 63 (2016), 474–479.
12. [12] Li, X., Galliher-Beckley, A., Huang, H., Sun, X., Shi, J., Peptide nanofiber hydrogel adjuvanted live virus vaccine enhances cross-protective immunity to porcine reproductive and respiratory syndrome virus. Vaccine 31 (2013), 4508–4515.
13. [13] Galliher-Beckley, A., Li, X., Bates, J.T., Madera, R., Waters, A., Nietfeld, J., et al. Pigs immunized with Chinese highly pathogenic PRRS virus modified live vaccine are protected from challenge with North American PRRSV strain NADC-20. Vaccine 33 (2015), 3518–3525.
14. [14] Lopez, O.J., Osorio, F.A., Role of neutralizing antibodies in PRRSV protective immunity. Vet Immunol Immunopathol 102 (2004), 155–163.
15. [15] Vanhee, M., Delputte, P.L., Delrue, I., Geldhof, M.F., Nauwynck, H.J., Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies. Vet Res, 40, 2009, 63.