Small Heat-shock Proteins Prevent α-synuclein aggregation via transient interactions and their efficacy is affected by the rate of aggregation

Journal of Biological Chemistry

Volumn 291, Issue 43, 2016, Pages 22618-22629

  Cox, Dezerae ^a   Selig, Emily ^b   Griffin, Michael D W ^b   Carver, John A ^c   Ecroyd, Heath ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

NEURODEGENERATIVE DISEASES;

CHAPERONE ACTION; FIBRIL FORMATION; MOLECULAR CHAPERONES; MOLECULAR MECHANISM; PROTEIN AGGREGATION; SMALL HEAT SHOCK PROTEINS; STABLE COMPLEXES; TRANSIENT INTERACTIONS;

PROTEINS;

ALPHA BETA CRYSTALLIN; ALPHA SYNUCLEIN; AMYLOID; CHAPERONE; HEAT SHOCK PROTEIN 27; SMALL HEAT SHOCK PROTEIN; UNCLASSIFIED DRUG; ALPHA CRYSTALLIN; HSPB1 PROTEIN, HUMAN; PROTEIN AGGREGATE; SNCA PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR PARAMETERS; CELLULAR PROTEOSTASIS; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE ANALYSIS; IN VITRO STUDY; INCUBATION TIME; LIMIT OF DETECTION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN STABILITY; SEDIMENTATION RATE; SIZE EXCLUSION CHROMATOGRAPHY; TRANSIENT INTERACTION; ULTRACENTRIFUGATION; CHEMISTRY; HUMAN; METABOLISM;

ALPHA-CRYSTALLIN B CHAIN; ALPHA-SYNUCLEIN; HSP27 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN AGGREGATES;

EID: 84992316267     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.739250     Document Type: Article

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