Metformin alters DNA methylation genome-wide via the H19/SAHH axis

Oncogene

Volumn 36, Issue 17, 2017, Pages 2345-2354

  Zhong, T ^a,b   Men, Y ^a,c   Lu, L ^a   Geng, T ^a,d   Zhou, J ^a,e   Mitsuhashi, A ^f   Shozu, M ^f   Maihle, N J ^g   Carmichael, G G ^h   Taylor, H S ^a   Huang, Y ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GANNAN MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

^d THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^e ZHEJIANG UNIVERSITY   (China)

^f CHIBA UNIVERSITY   (Japan)

^g MEDICAL COLLEGE OF GEORGIA   (United States)

^h UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSYLHOMOCYSTEINASE; DNA METHYLTRANSFERASE 3B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN G; MESSENGER RNA; METFORMIN; RNA H19; DNA (CYTOSINE 5) METHYLTRANSFERASE; H19 LONG NON-CODING RNA; LONG UNTRANSLATED RNA; MICRORNA; MIRNLET7 MICRORNA, HUMAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOGENESIS; CELL DENSITY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA METHYLATION; DRUG DOSE INCREASE; ENDOMETRIAL CANCER CELL LINE; ENDOMETRIOID CARCINOMA; ENZYME ACTIVATION; FEMALE; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MCF-7 CELL LINE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA DEGRADATION; RNA STABILITY; TUMOR PROMOTION; CARCINOGENESIS; CHEMISTRY; DRUG EFFECTS; GENETICS; GENOMICS; METABOLISM; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOSYLHOMOCYSTEINASE; AMP-ACTIVATED PROTEIN KINASES; CARCINOGENESIS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME ACTIVATION; GENOMICS; HUMANS; MCF-7 CELLS; METFORMIN; MICRORNAS; RNA STABILITY; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84992315333     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2016.391     Document Type: Article

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