Further insights into cortactin conformational regulation

BioArchitecture

Volumn 1, Issue 1, 2011, Pages 21-23

  Evans, Jason V ^a   Kelley, Laura C ^a   Hayes, Karen E ^a   Ammer, Amanda Gatesman ^a   Martin, Karen H ^a   Weed, Scott A ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Circular dichroism; Conformation; Cortactin; ERK1 2; Invasion; Motility; N WASp; Phosphorylation; Src

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; CORTACTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN SH3; PROTEIN TYROSINE KINASE;

ACTIN FILAMENT; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; CIRCULAR DICHROISM; CIS TRANS ISOMERISM; CONFORMATIONAL TRANSITION; HUMAN; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NOTE; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 84992268913     PISSN: 19490992     EISSN: 1949100X     Source Type: Journal    
DOI: 10.4161/bioa.1.1.14631     Document Type: Note

References (20)

1. Weaver AM. Cortactin in tumor invasiveness. Cancer Lett 2008; 265:157-66.
2. Ammer AG, Weed SA. Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton 2008; 65:687-707.
3. Campbell DH, Sutherland RL, Daly RJ. Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin. Cancer Res 1999; 59:5376-85.
4. Kruchten AE, Krueger EW, Wang Y, McNiven MA. Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions. Am J Physiol Cell Physiol 2008; 295:1113-22.
5. Ayala I, Baldassarre M, Giacchetti G, et al. Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation. J Cell Sci 2008; 121:369-78.
6. Tehrani S, Tomasevic N, Weed S, Sakowicz R, Cooper JA. Src phosphorylation of cortactin enhances actin assembly. Proc Natl Acad Sci USA 2007; 104:11933-8.
7. Oser M, Yamaguchi H, Mader CC, et al. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol 2009; 186:571-87.
8. Oser M, Mader CC, Gil-Henn H, et al. Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci 2010; 123:3662-73.
9. Tomasevic N, Jia Z, Russell A, et al. Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck and PI(4,5)P2. Biochemistry 2007; 46:3494-502.
10. Padrick SB, Rosen MK. Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem 2010; 79:707-35.
11. Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol 2004; 24:5269-80.
12. Wu H, Reynolds AB, Kanner SB, Vines RR, Parsons JT. Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol 1991; 11:5113-24.
13. Wu H, Parsons JT. Cortactin, an 80/85 kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol 1993; 120:1417-26.
14. Huang C, Ni Y, Wang T, Gao Y, Haudenschild CC, Zhan X. Downregulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. J Biol Chem 1997; 272:13911-5.
15. van Damme H, Brok H, Schuuring-Scholtes E, Schuuring E. The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification. J Biol Chem 1997; 272:7374-80.
16. Lua BL, Low BC. Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Lett 2005; 579:577-85.
17. Cowieson NP, King G, Cookson D, et al. Cortactin adopts a globular conformation and bundles actin into sheets. J Biol Chem 2008; 283:16187-93.
18. Zhang LH, Tian B, Diao LR, et al. Dominant expression of 85 kDa form of cortactin in colorectal cancer. J Cancer Res Clin Oncol 2006; 132:113-20.
19. Schiene C, Fischer G. Enzymes that catalyse the restructuring of proteins. Curr Opin Struct Biol 2000; 10:40-5.
20. Weaver AM, Heuser JE, Karginov AV, Lee WL, Parsons JT, Cooper JA. Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol 2002; 12:1270-8.