메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages 14-18

The role of Endoplasmic Reticulum Aminopeptidase 1(ERAP1) in Ankylosing Spondylitis

Author keywords

Ankylosing spondylitis; Genetic loci; Heritability; Natural Killer cells; Non HLA genes

Indexed keywords

AMINOPEPTIDASE; ARTHRITOGENIC PEPTIDE; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; HLA B27 ANTIGEN; HOMODIMER; PEPTIDE; UNCLASSIFIED DRUG;

EID: 84992238303     PISSN: 09733698     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injr.2014.02.001     Document Type: Review
Times cited : (1)

References (39)
  • 1
    • 34249800645 scopus 로고    scopus 로고
    • Tumour necrosis factor blockers and structural remodelling in ankylosing spondylitis: What is reality and what is fiction?
    • G. Schett, R. Landewe, and D. van der Heijde Tumour necrosis factor blockers and structural remodelling in ankylosing spondylitis: what is reality and what is fiction? Ann Rheum Dis 66 2007 709 711
    • (2007) Ann Rheum Dis , vol.66 , pp. 709-711
    • Schett, G.1    Landewe, R.2    Van Der Heijde, D.3
  • 2
    • 80051721521 scopus 로고    scopus 로고
    • Quality of life and related variables in patients with ankylosing spondylitis
    • H. Bodur, S. Ataman, and A. Rezvani et al. Quality of life and related variables in patients with ankylosing spondylitis Qual Life Res 20 2011 543 549
    • (2011) Qual Life Res , vol.20 , pp. 543-549
    • Bodur, H.1    Ataman, S.2    Rezvani, A.3
  • 4
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • D.M. Evans, C.C. Spencer, and J.J. Pointon et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Nat Genet 43 2011 761 767
    • (2011) Nat Genet , vol.43 , pp. 761-767
    • Evans, D.M.1    Spencer, C.C.2    Pointon, J.J.3
  • 5
    • 77955332608 scopus 로고    scopus 로고
    • Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential
    • N. Haroon, and R.D. Inman Endoplasmic reticulum aminopeptidases: biology and pathogenic potential Nat Rev Rheumatol 6 2010 461 467
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 461-467
    • Haroon, N.1    Inman, R.D.2
  • 7
    • 33846988640 scopus 로고    scopus 로고
    • In the absence of aminopeptidase ERAAP, MHC class i molecules present many unstable and highly immunogenic peptides
    • G.E. Hammer, F. Gonzalez, E. James, H. Nolla, and N. Shastri In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides Nat Immunol 8 2007 101 108
    • (2007) Nat Immunol , vol.8 , pp. 101-108
    • Hammer, G.E.1    Gonzalez, F.2    James, E.3    Nolla, H.4    Shastri, N.5
  • 8
    • 0028501327 scopus 로고
    • A sequential model for peptide binding and transport by the transporters associated with antigen processing
    • P.M. van Endert, R. Tampe, and T.H. Meyer et al. A sequential model for peptide binding and transport by the transporters associated with antigen processing Immunity 1 1994 491 500
    • (1994) Immunity , vol.1 , pp. 491-500
    • Van Endert, P.M.1    Tampe, R.2    Meyer, T.H.3
  • 9
    • 26244455510 scopus 로고    scopus 로고
    • Mechanisms of MHC class i restricted antigen processing and cross-presentation
    • P. Cresswell, A.L. Ackerman, and A. Giodini et al. Mechanisms of MHC class I restricted antigen processing and cross-presentation Immunol Rev 207 2005 145 157
    • (2005) Immunol Rev , vol.207 , pp. 145-157
    • Cresswell, P.1    Ackerman, A.L.2    Giodini, A.3
  • 10
    • 0034907526 scopus 로고    scopus 로고
    • MHC class i molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum
    • N. Brouwenstijn, T. Serwold, and N. Shastri MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum Immunity 15 2001 95 104
    • (2001) Immunity , vol.15 , pp. 95-104
    • Brouwenstijn, N.1    Serwold, T.2    Shastri, N.3
  • 11
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Wellcome Trust Case Control Consortium Australo-Anglo-American Spondylitis Consortium (TASC)
    • Wellcome Trust Case Control Consortium Australo-Anglo-American Spondylitis Consortium (TASC) P.R. Burton et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Nat Genet 39 2007 1329 1337
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1
  • 12
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Spondyloarthritis Research Consortium of Canada (SPARCC), Australo-Anglo-American Spondyloarthritis Consortium (TASC), Wellcome Trust Case Control Consortium 2 (WTCCC2)
    • D.M. Evans, C.C. Spencer, J.J. Pointon Spondyloarthritis Research Consortium of Canada (SPARCC), Australo-Anglo-American Spondyloarthritis Consortium (TASC), Wellcome Trust Case Control Consortium 2 (WTCCC2) Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Nat Genet 43 2011 761 767
    • (2011) Nat Genet , vol.43 , pp. 761-767
    • Evans, D.M.1    Spencer, C.C.2    Pointon, J.J.3
  • 13
    • 84887669101 scopus 로고    scopus 로고
    • Protective effect of an ERAP1 haplotype in ankylosing spondylitis: Investigating non-MHC genes in HLA-B27-positive individuals
    • B.F. Bettencourt, F.L. Rocha, and H. Alves et al. Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals Rheumatol (Oxford) 52 2013 2168 2176
    • (2013) Rheumatol (Oxford) , vol.52 , pp. 2168-2176
    • Bettencourt, B.F.1    Rocha, F.L.2    Alves, H.3
  • 14
    • 66049103503 scopus 로고    scopus 로고
    • Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
    • W.P. Maksymowych, R.D. Inman, D.D. Gladman, J.P. Reeve, A. Pope, and P. Rahman Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis Arthritis Rheum 60 2009 1317 1323
    • (2009) Arthritis Rheum , vol.60 , pp. 1317-1323
    • Maksymowych, W.P.1    Inman, R.D.2    Gladman, D.D.3    Reeve, J.P.4    Pope, A.5    Rahman, P.6
  • 15
    • 77950331522 scopus 로고    scopus 로고
    • Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis
    • F.W. Tsui, N. Haroon, and J.D. Reveille et al. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis Ann Rheum Dis 69 2010 733 736
    • (2010) Ann Rheum Dis , vol.69 , pp. 733-736
    • Tsui, F.W.1    Haroon, N.2    Reveille, J.D.3
  • 16
    • 33644908217 scopus 로고    scopus 로고
    • Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1
    • Y. Goto, A. Hattori, Y. Ishii, and M. Tsujimoto Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 FEBS Lett 580 2006 1833 1838
    • (2006) FEBS Lett , vol.580 , pp. 1833-1838
    • Goto, Y.1    Hattori, A.2    Ishii, Y.3    Tsujimoto, M.4
  • 17
    • 79951817611 scopus 로고    scopus 로고
    • Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme
    • I. Evnouchidou, R.P. Kamal, and S.S. Seregin et al. Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme J Immunol 186 2011 1909 1913
    • (2011) J Immunol , vol.186 , pp. 1909-1913
    • Evnouchidou, I.1    Kamal, R.P.2    Seregin, S.S.3
  • 18
    • 84894192415 scopus 로고    scopus 로고
    • Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands
    • A. Martin-Esteban, P. Gomez-Molina, A. Sanz-Bravo, and J.A. Lopez de Castro Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands J Biol Chem 289 2014 3978 3990
    • (2014) J Biol Chem , vol.289 , pp. 3978-3990
    • Martin-Esteban, A.1    Gomez-Molina, P.2    Sanz-Bravo, A.3    Lopez De Castro, J.A.4
  • 19
    • 84879663069 scopus 로고    scopus 로고
    • Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity
    • E. Reeves, C.J. Edwards, T. Elliot, and E. James Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity J Immunol 191 2013 35 43
    • (2013) J Immunol , vol.191 , pp. 35-43
    • Reeves, E.1    Edwards, C.J.2    Elliot, T.3    James, E.4
  • 20
    • 0027328672 scopus 로고
    • HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis
    • E. Hermann, D.T. Yu, K.H. Meyer zum Buschenfelde, and B. Fleischer HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis Lancet 342 1993 646 650
    • (1993) Lancet , vol.342 , pp. 646-650
    • Hermann, E.1    Yu, D.T.2    Meyer Zum Buschenfelde, K.H.3    Fleischer, B.4
  • 21
    • 84869219870 scopus 로고    scopus 로고
    • Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo
    • N. Garcia-Medel, A. Sanz-Bravo, and D. Van Nguyen et al. Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo Mol Cell Proteomics: MCP 11 2012 1416 1429
    • (2012) Mol Cell Proteomics: MCP , vol.11 , pp. 1416-1429
    • Garcia-Medel, N.1    Sanz-Bravo, A.2    Van Nguyen, D.3
  • 22
    • 0037438486 scopus 로고    scopus 로고
    • CD8+ T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats
    • E. May, M.L. Dorris, and N. Satumtira et al. CD8+ T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats J Immunol 170 2003 1099 1105
    • (2003) J Immunol , vol.170 , pp. 1099-1105
    • May, E.1    Dorris, M.L.2    Satumtira, N.3
  • 23
    • 0029083655 scopus 로고
    • Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: A model of human spondyloarthropathies
    • S.D. Khare, H.S. Luthra, and C.S. David Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies J Exp Med 182 1995 1153 1158
    • (1995) J Exp Med , vol.182 , pp. 1153-1158
    • Khare, S.D.1    Luthra, H.S.2    David, C.S.3
  • 24
    • 14944368161 scopus 로고    scopus 로고
    • MHC class i down-regulation: Tumour escape from immune surveillance?
    • J. Bubenik MHC class I down-regulation: tumour escape from immune surveillance? Int J Oncol 25 2004 487 491
    • (2004) Int J Oncol , vol.25 , pp. 487-491
    • Bubenik, J.1
  • 25
    • 0142180035 scopus 로고    scopus 로고
    • Virus evasion of MHC class i molecule presentation
    • J.L. Petersen, C.R. Morris, and J.C. Solheim Virus evasion of MHC class I molecule presentation J Immunol 171 2003 4473 4478
    • (2003) J Immunol , vol.171 , pp. 4473-4478
    • Petersen, J.L.1    Morris, C.R.2    Solheim, J.C.3
  • 26
    • 18844413022 scopus 로고    scopus 로고
    • A new self: MHC-class-I-independent natural-killer-cell self-tolerance
    • V. Kumar, and M.E. Mcnerney A new self: MHC-class-I-independent natural-killer-cell self-tolerance Nat Rev Immunol 5 2005 363 374
    • (2005) Nat Rev Immunol , vol.5 , pp. 363-374
    • Kumar, V.1    McNerney, M.E.2
  • 27
    • 0035889905 scopus 로고    scopus 로고
    • Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures
    • R.L. Allen, T. Raine, A. Haude, J. Trowsdale, and M.J. Wilson Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures J Immunol 167 2001 5543 5547
    • (2001) J Immunol , vol.167 , pp. 5543-5547
    • Allen, R.L.1    Raine, T.2    Haude, A.3    Trowsdale, J.4    Wilson, M.J.5
  • 28
    • 0033136630 scopus 로고    scopus 로고
    • Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure
    • R.L. Allen, C.A. O'Callaghan, and A.J. McMichael et al. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure J Immunol 162 1999 5045 5048
    • (1999) J Immunol , vol.162 , pp. 5045-5048
    • Allen, R.L.1    O'Callaghan, C.A.2    McMichael, A.J.3
  • 29
    • 0037352755 scopus 로고    scopus 로고
    • Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling
    • L.A. Bird, C.A. Peh, S. Kollnberger, T. Elliott, A.J. McMichael, and P. Bowness Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling Eur J Immunol 33 2003 748 759
    • (2003) Eur J Immunol , vol.33 , pp. 748-759
    • Bird, L.A.1    Peh, C.A.2    Kollnberger, S.3    Elliott, T.4    McMichael, A.J.5    Bowness, P.6
  • 30
    • 84857924158 scopus 로고    scopus 로고
    • Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis
    • N. Haroon, F.W. Tsui, and B. Uchanska-Ziegler et al. Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis Ann Rheum Dis 71 2012 589 595
    • (2012) Ann Rheum Dis , vol.71 , pp. 589-595
    • Haroon, N.1    Tsui, F.W.2    Uchanska-Ziegler, B.3
  • 31
    • 0036846149 scopus 로고    scopus 로고
    • Cell-surface expression and immune receptor recognition of HLA-B27 homodimers
    • S. Kollnberger, L. Bird, and M.Y. Sun et al. Cell-surface expression and immune receptor recognition of HLA-B27 homodimers Arthritis Rheum 46 2002 2972 2982
    • (2002) Arthritis Rheum , vol.46 , pp. 2972-2982
    • Kollnberger, S.1    Bird, L.2    Sun, M.Y.3
  • 32
    • 79951835541 scopus 로고    scopus 로고
    • Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis
    • P. Bowness, A. Ridley, and J. Shaw et al. Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis J Immunol 186 2011 2672 2680
    • (2011) J Immunol , vol.186 , pp. 2672-2680
    • Bowness, P.1    Ridley, A.2    Shaw, J.3
  • 33
    • 0032742012 scopus 로고    scopus 로고
    • Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies
    • J.P. Mear, K.L. Schreiber, and C. Münz et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies J Immunol 163 1999 6665 6670
    • (1999) J Immunol , vol.163 , pp. 6665-6670
    • Mear, J.P.1    Schreiber, K.L.2    Münz, C.3
  • 34
    • 0037189545 scopus 로고    scopus 로고
    • HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum
    • N.S. Dangoria, M.L. DeLay, and D.J. Kingsbury et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum J Biol Chem 77 2002 23459 23468
    • (2002) J Biol Chem , vol.77 , pp. 23459-23468
    • Dangoria, N.S.1    Delay, M.L.2    Kingsbury, D.J.3
  • 35
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • C. Hetz, E. Chevet, and H.P. Harding Targeting the unfolded protein response in disease Nat Rev Drug Discov 12 2013 703 719
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 36
    • 50249116184 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in immunity and autoimmunity
    • D.J. Todd, A.H. Lee, and L.H. Glimcher The endoplasmic reticulum stress response in immunity and autoimmunity Nat Rev Immunol 8 2008 663 674
    • (2008) Nat Rev Immunol , vol.8 , pp. 663-674
    • Todd, D.J.1    Lee, A.H.2    Glimcher, L.H.3
  • 37
    • 33846194065 scopus 로고    scopus 로고
    • HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlated with the magnitude of the unfolded protein response in transgenic rats
    • M.J. Turner, M.L. Delay, S. Bai, E. Klenk, and R.A. Colbert HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlated with the magnitude of the unfolded protein response in transgenic rats Arthritis Rheum 56 2007 215 223
    • (2007) Arthritis Rheum , vol.56 , pp. 215-223
    • Turner, M.J.1    Delay, M.L.2    Bai, S.3    Klenk, E.4    Colbert, R.A.5
  • 38
    • 78049347495 scopus 로고    scopus 로고
    • A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2
    • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 A. Strange et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 Nat Genet 42 2010 985 990
    • (2010) Nat Genet , vol.42 , pp. 985-990
    • Strange, A.1
  • 39
    • 84873091770 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1
    • Y. Kirino, G. Bertsias, and Y. Ishigatsubo et al. Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1 Nat Genet 45 2013 202 207
    • (2013) Nat Genet , vol.45 , pp. 202-207
    • Kirino, Y.1    Bertsias, G.2    Ishigatsubo, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.