Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 21, 2016, Pages 5354-5360

  Tong, Ling ^a   Yu, Wensheng ^a   Coburn, Craig A ^a   Chen, Lei ^a   Selyutin, Oleg ^a   Zeng, Qingbei ^a   Dwyer, Michael P ^a   Nair, Anilkumar G ^a   Shankar, Bandarpalle B ^a   Kim, Seong Heon ^a   Yang, De Yi ^a   Rosenblum, Stuart B ^a   Ruck, Rebecca T ^a   Davies, Ian W ^a   Hu, Bin ^b   Zhong, Bin ^b   Hao, Jinglai ^b   Ji, Tao ^b   Zan, Shuai ^b   Liu, Rong ^a   Agrawal, Sony ^a   Carr, Donna ^a   Curry, Stephanie ^a   McMonagle, Patricia ^a   Bystol, Karin ^a   Lahser, Frederick ^a   Ingravallo, Paul ^a   Chen, Shiying ^a   Asante Appiah, Ernest ^a   Kozlowski, Joseph A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

Author keywords

Direct acting antiviral agents; Elbasvir; HCV infection treatment; HCV NS5A inhibitor; Indole based tetracyclic core; MK 8742

Indexed keywords

INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5A INHIBITOR; PROLINE DERIVATIVE; TETRACYCLINE DERIVATIVE; 2-(PYRROLIDIN-2-YL)-5-(2-(4-(5-(PYRROLIDIN-2-YL)-1H-IMIDAZOL-2-YL)PHENYL)BENZOFURAN-5-YL)-1H-IMIDAZOLE; ANTIVIRUS AGENT; BENZOFURAN DERIVATIVE; IMIDAZOLE DERIVATIVE; NS-5 PROTEIN, HEPATITIS C VIRUS; PROLINE; VIRAL PROTEIN;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; NONHUMAN; RAT; REPLICON; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY;

ANTIVIRAL AGENTS; BENZOFURANS; IMIDAZOLES; INDOLES; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84992223363     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.097     Document Type: Article

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