Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 19, 2016, Pages 4851-4856

  Yu, Wensheng ^a   Zhou, Guowei ^a   Coburn, Craig A ^a   Zeng, Qingbei ^a   Tong, Ling ^a   Dwyer, Michael P ^a   Hu, Bin ^b   Zhong, Bin ^b   Hao, Jinglai ^b   Ji, Tao ^b   Zan, Shuai ^b   Chen, Lei ^a   Mazzola, Robert ^a   Kim, Jae Hun ^a   Sha, Deyou ^a   Selyutin, Oleg ^a   Rosenblum, Stuart B ^a   Lavey, Brian ^a   Nair, Anilkumar G ^a   Heon Kim, Seong ^a   Keertikar, Kerry M ^a   Rokosz, Laura ^a   Agrawal, Sony ^a   Liu, Rong ^a   Xia, Ellen ^a   Zhai, Ying ^a   Curry, Stephanie ^a   McMonagle, Patricia ^a   Ingravallo, Paul ^a   Asante Appiah, Ernest ^a   Chen, Shiying ^a   Kozlowski, Joseph A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

Author keywords

Elbasvir; HCV DAA; HCV infection; HCV NS5A inhibitor; MK 8742; Resistance associated variants

Indexed keywords

ELBASVIR; ELBASVIR DERIVATIVE; INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5A INHIBITOR; PROLINE; TETRACYCLIC INDOLE CORE DERIVATIVE; UNCLASSIFIED DRUG; 2-(PYRROLIDIN-2-YL)-5-(2-(4-(5-(PYRROLIDIN-2-YL)-1H-IMIDAZOL-2-YL)PHENYL)BENZOFURAN-5-YL)-1H-IMIDAZOLE; ANTIVIRUS AGENT; BENZOFURAN DERIVATIVE; IMIDAZOLE DERIVATIVE; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRAL PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SYNTHESIS; ELIMINATION HALF-LIFE; GENOTYPE; HEPATITIS C VIRUS; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; REPLICON; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY;

ANTIVIRAL AGENTS; BENZOFURANS; IMIDAZOLES; INDOLES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84985961536     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.002     Document Type: Article

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20. 1H NMR spectra.
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