Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 16, 2016, Pages 4106-4111

  Dwyer, Michael P ^a   Keertikar, Kerry M ^a   Chen, Lei ^a   Tong, Ling ^a   Selyutin, Oleg ^a   Nair, Anilkumar G ^a   Yu, Wensheng ^a   Zhou, Guowei ^a   Lavey, Brian J ^a   Yang, De Yi ^a   Wong, Michael ^a   Kim, Seong Heon ^a   Coburn, Craig A ^a   Rosenblum, Stuart B ^a   Zeng, Qingbei ^a   Jiang, Yueheng ^a   Shankar, Bandarpalle B ^a   Rizvi, Razia ^a   Nomeir, Amin A ^a   Liu, Rong ^a   Agrawal, Sony ^a   Xia, Ellen ^a   Kong, Rong ^a   Zhai, Ying ^a   Ingravallo, Paul ^a   Asante Appiah, Ernest ^a   Kozlowski, Joseph A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Capping; Hepatitis C; Indole; Infectious diseases; NS5A

Indexed keywords

INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5A INHIBITOR; TETRACYCLIC INDOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRAL PROTEIN;

AREA UNDER THE CURVE; ARTICLE; DRUG SYNTHESIS; EC90; HIGH TEMPERATURE; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; GENOTYPE; HALF LIFE TIME; HEPACIVIRUS; METABOLISM; RAT; RECEIVER OPERATING CHARACTERISTIC;

ANIMALS; ANTIVIRAL AGENTS; AREA UNDER CURVE; GENOTYPE; HALF-LIFE; HEPACIVIRUS; INDOLES; RATS; ROC CURVE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84979520768     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.06.063     Document Type: Article

References (20)

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16. 2. Each enantiomer from the SFC separation (15 and the epimer) was progressed thru the synthetic sequence in Scheme 4 to prepare both Moc L-Val diastereomers to compare against MK-8742 to confirm the stereochemistry at the aminal position.
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19. 2. Each enantiomer from the SFC separation (39 and the epimer) was progressed thru the synthetic sequence in Scheme 4 to prepare both Moc L-Val diastereomers to compare against MK-8742 to confirm the stereochemistry at the aminal position.
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