Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

ACS Chemical Biology

Volumn 11, Issue 10, 2016, Pages 2734-2743

  Allen, John G ^a   Mujacic, Mirna ^b   Frohn, Michael J ^a   Pickrell, Alex J ^a   Kodama, Paul ^b   Bagal, Dhanashri ^a   San Miguel, Tisha ^a   Sickmier, E Allen ^a   Osgood, Steve ^a   Swietlow, Aleksander ^a   Li, Vivian ^a   Jordan, John B ^a   Kim, Ki Won ^a   Rousseau, Anne Marie C ^b   Kim, Yong Jae ^a   Caille, Seb ^a   Achmatowicz, Mike ^a   Thiel, Oliver ^a   Fotsch, Christopher H ^a   Reddy, Pranhitha ^b   McCarter, John D ^a   more..

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUCOSE; GUANOSINE DIPHOSPHATE MANNOSE; HYDROLYASE; MOLECULAR LIBRARY;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY TITER; ARTICLE; BINDING SITE; CELL CULTURE; CELL SURFACE; CHO CELL LINE; CONTROLLED STUDY; CRYSTALLIZATION; FUCOSYLATION; MAMMAL CELL; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CRICETULUS; HAMSTER; MASS SPECTROMETRY; METABOLISM; MOLECULAR LIBRARY; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; FUCOSE; GUANOSINE DIPHOSPHATE MANNOSE; HYDRO-LYASES; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; SURFACE PLASMON RESONANCE;

EID: 84992176859     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.6b00460     Document Type: Article

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