Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 40021-40030

  Zandberg, Wesley F ^a   Kumarasamy, Jayakanthan ^a   Pinto, B Mario ^a   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION MOLECULES; ADHESIVE PROPERTIES; CANCER CELLS; CELL SURFACES; CELL-ADHESION PROTEINS; DONOR SUBSTRATES; GENERAL APPROACH; GLYCOSYL TRANSFERASE; GLYCOSYLTRANSFERASES; HEPG2 CELLS; HUMAN ENDOTHELIAL CELLS; MICROMOLAR RANGE; SELECTINS; SUGAR NUCLEOTIDES; TETRASACCHARIDES;

BIOSYNTHESIS; CELL ADHESION; CELL MEMBRANES; ENDOTHELIAL CELLS; SUGARS; TISSUE;

BIOCHEMISTRY;

5 THIOFUCOSE; ALPHA 1,3 FUCOSYLTRANSFERASE; FUCOSE; GUANOSINE DIPHOSPHATE 5 THIOFUCOSE; SELECTIN; SIALYL LEWIS X ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CANCER CELL; CELL ADHESION; CELL STRAIN HEPG2; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; FUCOSYLATION; HUMAN; HUMAN CELL; METABOLIC ENGINEERING; METABOLIC INHIBITION; PRIORITY JOURNAL;

ANIMALS; CELL ADHESION; CHO CELLS; CRICETINAE; CRICETULUS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FUCOSE; FUCOSYLTRANSFERASES; GLYCOSYLATION; HEP G2 CELLS; HUMANS; METABOLIC ENGINEERING; OLIGOSACCHARIDES; SELECTINS;

EID: 84869234450     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.403568     Document Type: Article

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