Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction

Circulation

Volumn 134, Issue 20, 2016, Pages 1532-1541

  Pickering, John W ^a,c   Greenslade, Jaimi H ^a   Cullen, Louise ^a   Flaws, Dylan ^a   Parsonage, William ^d   Aldous, Sally ^a,b   George, Peter ^e   Worster, Andrew ^f   Kavsak, Peter A ^f   Than, Martin P ^a  

^a CANTERBURY DISTRICT HEALTH BOARD   (New Zealand)

^b CHRISTCHURCH HOSPITAL   (New Zealand)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^e CANTERBURY HEALTH LABORATORIES   (New Zealand)

^f MCMASTER UNIVERSITY   (Canada)

Author keywords

diagnosis; emergency department; emergency medicine; myocardial infarction; troponin

Indexed keywords

TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; ALGORITHM; ARTICLE; AUSTRALIA; CANADA; CARDIAC PATIENT; CARDIOVASCULAR RISK; CLINICAL OUTCOME; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAM; EMERGENCY WARD; ENZYME ASSAY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HIGH SENSITIVITY TROPONIN I ASSAY; HIGH SENSITIVITY TROPONIN T ASSAY; HUMAN; IMMUNOASSAY ANALYZER; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR DIAGNOSIS; MULTICENTER STUDY; NEW ZEALAND; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; PREDICTIVE VALUE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SECONDARY ANALYSIS; SENSITIVITY AND SPECIFICITY; THORAX PAIN; VALIDATION STUDY; CHEMISTRY; CLINICAL TRIAL; EUROPE; MYOCARDIAL INFARCTION;

EUROPE; FEMALE; HUMANS; MALE; MYOCARDIAL INFARCTION; TROPONIN I; TROPONIN T;

EID: 84992130251     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.022677     Document Type: Article

References (36)

1. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S, Baumgartner H, Gaemperli O, Achenbach S, Agewall S, Badimon L, Baigent C, Bueno H, Bugiardini R, Carerj S, Casselman F, Cuisset T, Erol Ç, Fitzsimons D, Halle M, Hamm C, Hildick-Smith D, Huber K, Iliodromitis E, James S, Lewis BS, Lip GY, Piepoli MF, Richter D, Rosemann T, Sechtem U, Steg PG, Vrints C, Luis Zamorano J; Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:267-315. doi: 10. 1093/eurheartj/ehv320.
2. Reichlin T, Schindler C, Drexler B, Twerenbold R, Reiter M, Zellweger C, Moehring B, Ziller R, Hoeller R, Rubini Gimenez M, Haaf P, Potocki M, Wildi K, Balmelli C, Freese M, Stelzig C, Freidank H, Osswald S, Mueller C. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med. 2012;172:1211-1218. doi: 10. 1001/archinternmed. 2012. 3698.
3. Reichlin T, Twerenbold R, Wildi K, Rubini Gimenez M, Bergsma N, Haaf P, Druey S, Puelacher C, Moehring B, Freese M, Stelzig C, Krivoshei L, Hillinger P, Jäger C, Herrmann T, Kreutzinger P, Radosavac M, Weidmann ZM, Pershyna K, Honegger U, Wagener M, Vuillomenet T, Campodarve I, Bingisser R, Miró Ò, Rentsch K, Bassetti S, Osswald S, Mueller C. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ. 2015;187:E243-E252. doi: 10. 1503/cmaj. 141349.
4. Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, deFilippi C, Mc-Cord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French J, Christenson R, Weiser S, Bendig G, Dilba P, Lindahl B; TRAPID-AMI Investigators. Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T. Ann Emerg Med. 2016;68:76. e4-87. e4. doi: 10. 1016/j. Annemergmed. 2015. 11. 013.
5. Rubini Gimenez M, Twerenbold R, Jaeger C, Schindler C, Puelacher C, Wildi K, Reichlin T, Haaf P, Merk S, Honegger U, Wagener M, Druey S, Schumacher C, Krivoshei L, Hillinger P, Herrmann T, Campodarve I, Rentsch K, Bassetti S, Osswald S, Mueller C. Onehour rule-in and rule-out of acute myocardial infarction using highsensitivity cardiac troponin I. Am J Med. 2015;128:861. e4-870. e4. doi: 10. 1016/j. Amjmed. 2015. 01. 046.
6. Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, Flaws D, Hammett CJ, Beam DM, Ardagh MW, Troughton R, Brown AF, George P, Florkowski CM, Kline JA, Peacock WF, Maisel AS, Lim SH, Lamanna A, Richards AM. 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. J Am Coll Cardiol. 2012;59:2091-2098. doi: 10. 1016/j. jacc. 2012. 02. 035.
7. Than M, Aldous S, Lord SJ, Goodacre S, Frampton CM, Troughton R, George P, Florkowski CM, Ardagh M, Smyth D, Jardine DL, Peacock WF, Young J, Hamilton G, Deely JM, Cullen L, Richards AM. A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Intern Med. 2014;174:51-58. doi: 10. 1001/jamainternmed. 2013. 11362.
8. Than MP, Pickering JW, Aldous SJ, Cullen L, Frampton CM, Peacock WF, Jaffe AS, Goodacre SW, Richards AM, Ardagh MW, Deely JM, Florkowski CM, George P, Hamilton GJ, Jardine DL, Troughton RW, van Wyk P, Young JM, Bannister L, Lord SJ. Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Ann Emerg Med. 2016;68:93. e1-102. e1. doi: 10. 1016/j. Annemergmed. 2016. 01. 001.
9. Kavsak PA, Worster A, You JJ, Oremus M, Shortt C, Phan K, Sohn KY, Veljkovic K, Devereaux PJ, Hill S, Bhanich-Supapol W, Jaffe AS. Ninety-minute vs 3-h performance of high-sensitivity cardiac troponin assays for predicting hospitalization for acute coronary syndrome. Clin Chem. 2013;59:1407-1410. doi: 10. 1373/ clinchem. 2013. 208595.
10. Luepker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D, Goldberg RJ, Hand MM, Jaffe AS, Julian DG, Levy D, Manolio T, Mendis S, Mensah G, Pajak A, Prineas RJ, Reddy KS, Roger VL, Rosamond WD, Shahar E, Sharrett AR, Sorlie P, Tunstall-Pedoe H; AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; National Heart, Lung, and Blood Institute. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: A statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation. 2003;108:2543-2549. doi: 10. 1161/01. CIR. 0000100560. 46946. EA.
11. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, Katus HA, Newby LK, Ravkilde J, Chaitman B, Clemmensen PM, Dellborg M, Hod H, Porela P, Underwood R, Bax JJ, Beller GA, Bonow R, Van der Wall EE, Bassand JP, Wijns W, Ferguson TB, Steg PG, Uretsky BF, Williams DO, Armstrong PW, Antman EM, Fox KA, Hamm CW, Ohman EM, Simoons ML, Poole-Wilson PA, Gurfinkel EP, Lopez-Sendon JL, Pais P, Mendis S, Zhu JR, Wallentin LC, Fernández-Avilés F, Fox KM, Parkhomenko AN, Priori SG, Tendera M, Voipio-Pulkki LM, Vahanian A, Camm AJ, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Morais J, Brener S, Harrington R, Morrow D, Lim M, Martinez-Rios MA, Steinhubl S, Levine GN, Gibler WB, Goff D, Tubaro M, Dudek D, Al-Attar N; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation. 2007;116:2634-2653. doi: 10. 1161/CIRCULATIONAHA.107. 187397.
12. Cullen L, Than M, Brown AF, Richards M, Parsonage W, Flaws D, Hollander JE, Christenson RH, Kline JA, Goodacre S, Jaffe AS. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas. 2010;22:35-55. doi: 10. 1111/j. 1742-6723. 2010. 01256. x.
13. Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem. 2010;56:254-261. doi: 10. 1373/ clinchem. 2009. 132654.
14. Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clin Chem. 2012;58:1574-1581. doi: 10. 1373/clinchem. 2012. 192716.
15. Shah AS, Griffiths M, Lee KK, McAllister DA, Hunter AL, Ferry AV, Cruikshank A, Reid A, Stoddart M, Strachan F, Walker S, Collinson PO, Apple FS, Gray AJ, Fox KA, Newby DE, Mills NL. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study. BMJ. 2015;350:g7873.
16. Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc. 1927;22:209-212.
17. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med. 1998;17: 857-872.
18. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics. 1988;44:837-845.
19. Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27:157-172. doi: 10. 1002/sim. 2929.
20. Pickering JW, Endre ZH. New metrics for assessing diagnostic potential of candidate biomarkers. Clin J Am Soc Nephrol. 2012;7:1355-1364. doi: 10. 2215/CJN. 09590911.
21. R Core Team. R: A language and environment for statistical computing [Internet]. 2014; http://www. R-project. org. Accessed October 1, 2014.
22. Than M, Herbert M, Flaws D, Cullen L, Hess E, Hollander JE, Diercks D, Ardagh MW, Kline JA, Munro Z, Jaffe A. What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the emergency department?: A clinical survey. Int J Cardiol. 2013;166:752-754. doi: 10. 1016/j. ijcard. 2012. 09. 171.
23. Cullen L, Mueller C, Parsonage WA, Wildi K, Greenslade JH, Twerenbold R, Aldous S, Meller B, Tate JR, Reichlin T, Hammett CJ, Zellweger C, Ungerer JP, Rubini Gimenez M, Troughton R, Murray K, Brown AF, Mueller M, George P, Mosimann T, Flaws DF, Reiter M, Lamanna A, Haaf P, Pemberton CJ, Richards AM, Chu K, Reid CM, Peacock WF, Jaffe AS, Florkowski C, Deely JM, Than M. Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. J Am Coll Cardiol. 2013;62:1242-1249. doi: 10. 1016/j. jacc. 2013. 02. 078.
24. Kline JA, Johnson CL, Pollack CV Jr, Diercks DB, Hollander JE, Newgard CD, Garvey JL. Pretest probability assessment derived from attribute matching. BMC Med Inform Decis Mak. 2005;5:26. doi: 10. 1186/1472-6947-5-26.
25. Kavsak PA. High-five for high-sensitivity cardiac troponin T: depends on the precision and analytical platform. JAMA Intern Med. 2013;173:477. doi: 10. 1001/jamainternmed. 2013. 2270.
26. Kavsak PA, Don-Wauchope AC, Hill SA, Worster A. Acceptable analytical variation may exceed high-sensitivity cardiac troponin I cutoffs in early rule-out and rule-in acute myocardial infarction algorithms. Clin Chem. 2016;62:887-889. doi: 10. 1373/ clinchem. 2016. 255448.
27. Jaffe AS. TRAPID or trapped? Ann Emerg Med. 2016;68:88-91. doi: 10. 1016/j. Annemergmed. 2016. 01. 009.
28. Pickering JW, Greenslade JH, Cullen L, Flaws D, Parsonage W, George P, Worster A, Kavsak PA, Than MP. Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction. Heart. 2016;102:1270-1278. doi: 10. 1136/heartjnl-2015-308505.
29. Boeddinghaus J, Reichlin T, Cullen L, Greenslade JH, Parsonage WA, Hammett C, Pickering JW, Hawkins T, Aldous S, Twerenbold R, Wildi K, Nestelberger T, Grimm K, Rubini-Gimenez M, Puelacher C, Kern V, Rentsch K, Than M, Mueller C. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clin Chem. 2016;62:494-504. doi: 10. 1373/clinchem. 2015. 249508.
30. Aldous S, Pemberton C, Richards AM, Troughton R, Than M. Highsensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emerg Med J. 2012;29:805-810. doi: 10. 1136/emermed-2011-200222.
31. Kavsak PA, Ko DT, Wang X, Macrae AR, Jaffe AS. 2007 Universal myocardial infarction definition change criteria for risk stratification by use of a high-sensitivity cardiac troponin I assay. Clin Chem. 2010;56:487-489. doi: 10. 1373/clinchem. 2009. 136689.
32. Santaló M, Martin A, Velilla J, Povar J, Temboury F, Balaguer J, Muñoz M, Calmarza P, Ortiz C, Carratalá A, Gich I, Mercé J, Jaffe AS, Ordoñez-Llanos J. Using high-sensitivity troponin T: The importance of the proper gold standard. Am J Med. 2013;126:709-717. doi: 10. 1016/j. Amjmed. 2013. 03. 003.
33. Cullen L, Aldous S, Than M, Greenslade JH, Tate JR, George PM, Hammett CJ, Richards AM, Ungerer JP, Troughton RW, Brown AF, Flaws DF, Lamanna A, Pemberton CJ, Florkowski C, Pretorius CJ, Chu K, Parsonage WA. Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clin Biochem. 2014;47:321-326. doi: 10. 1016/j. clinbiochem. 2013. 11. 019.
34. Rubini Gimenez M, Twerenbold R, Reichlin T, Wildi K, Haaf P, Schaefer M, Zellweger C, Moehring B, Stallone F, Sou SM, Mueller M, Denhaerynck K, Mosimann T, Reiter M, Meller B, Freese M, Stelzig C, Klimmeck I, Voegele J, Hartmann B, Rentsch K, Osswald S, Mueller C. Direct comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur Heart J. 2014;35:2303-2311. doi: 10. 1093/ eurheartj/ehu188.
35. Ungerer JP, Marquart L, O'Rourke PK, Wilgen U, Pretorius CJ. Concordance, variance, and outliers in 4 contemporary cardiac troponin assays: implications for harmonization. Clin Chem. 2012;58:274-283. doi: 10. 1373/clinchem. 2011. 175059.
36. Nordenskjöld AM, Ahlström H, Eggers KM, Fröbert O, Jaffe AS, Venge P, Lindahl B. Short-and long-term individual variation in cardiac troponin in patients with stable coronary artery disease. Clin Chem. 2013;59:401-409. doi: 10. 1373/clinchem. 2012. 191700.