Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome

Journal of the American College of Cardiology

Volumn 62, Issue 14, 2013, Pages 1242-1249

  Cullen, Louise ^a,b   Mueller, Christian ^c   Parsonage, William A ^a,d   Wildi, Karin ^c   Greenslade, Jaimi H ^a,b,d   Twerenbold, Raphael ^c   Aldous, Sally ^c   Meller, Bernadette ^c   Tate, Jillian R ^a   Reichlin, Tobias ^c,e   Hammett, Christopher J ^a   Zellweger, Christa ^c   Ungerer, Jacobus P J ^a   Rubini Gimenez, Maria ^c   Troughton, Richard ^f   Murray, Karsten ^c   Brown, Anthony F T ^a,c   Mueller, Mira ^b   George, Peter ^e   Mosimann, Tamina ^c   Flaws, Dylan F ^d   Reiter, Miriam ^c   Lamanna, Arvin ^a   Haaf, Philip ^c   Pemberton, Christopher J ^f   Richards, A Mark ^f   Chu, Kevin ^a,c   Reid, Christopher M ^g   Peacock, William Frank ^h   Jaffe, Allan S ⁱ   Florkowski, Christopher ^e   Deely, Joanne M ^j,k   Than, Martin ^e   more..

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e CHRISTCHURCH HOSPITAL   (New Zealand)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g UNIVERSITY OF OTAGO   (New Zealand)

^h MONASH UNIVERSITY   (Australia)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j MAYO CLINIC   (United States)

^k CANTERBURY DISTRICT HEALTH BOARD   (New Zealand)

more..

Author keywords

acute myocardial infarction; ADAPT; APACE; chest pain; high sensitivity troponin I; TIMI

Indexed keywords

TROPONIN I;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; AGED; ANGIOCARDIOGRAPHY; ANGIOGRAPHY; ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAPHY; EMERGENCY PATIENT; EXERCISE TEST; FEMALE; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DETERMINATION; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; THORAX PAIN; THROMBOLYSIS IN MYOCARDIAL INFARCTION RISK SCORE; VALIDITY;

ACCELERATED DIAGNOSTIC PROTOCOL; ACS; ACUTE CORONARY SYNDROME(S); ACUTE MYOCARDIAL INFARCTION; ADAPT; ADP; AMI; APACE; CHEST PAIN; CI; CONFIDENCE INTERVAL; ECG; ELECTROCARDIOGRAPHY; HIGH-SENSITIVITY TROPONIN I; HS-TNI; MACE; MAJOR ADVERSE CARDIAC EVENT(S); THROMBOLYSIS IN MYOCARDIAL INFARCTION; TIMI;

ACUTE CORONARY SYNDROME; CHEST PAIN; CORONARY CARE UNITS; EARLY DIAGNOSIS; FOLLOW-UP STUDIES; HUMANS; PRACTICE GUIDELINES AS TOPIC; PROGNOSIS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 84881480711     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.02.078     Document Type: Article

References (28)

1. R. Body, S. Carley, and G. McDowell Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay J Am Coll Cardiol 58 2011 1332 1339
2. T. Keller, T. Zeller, and F. Ojeda Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction JAMA 306 2011 2684 2693
3. T. Reichlin, W. Hochholzer, and S. Bassetti Early diagnosis of myocardial infarction with sensitive cardiac troponin assays N Engl J Med 361 2009 858 867
4. S. Jairam, P. Jones, L. Samaraie, A. Chataline, J. Davidson, and R. Stewart Clinical diagnosis and outcomes for Troponin T 'positive' patients assessed by a high sensitivity compared with a 4th generation assay Emerg Med Australas 23 2011 490 501
5. J.A. De Lemos, D.A. Morrow, and C.R. de Filippi Highly sensitive troponin assays and the cardiology community: A love/hate relationship? Clin Chem 57 2011 826 829
6. M. Chase, J. Robey, K. Zogby, K. Sease, F. Shofer, and J. Hollander Prospective validation of the Thrombolysis in Myocardial Infarction risk score in the emergency department chest pain population Ann Emerg Med 48 2006 252 259
7. M. Than, L. Cullen, and C.M. Reid A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study Lancet 377 2011 1077 1084
8. M. Than, L. Cullen, and S. Aldous 2-hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT Trial J Am Coll Cardiol 59 2012 2091 2098
9. R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller High-sensitive troponin T measurements: what do we gain and what are the challenges? Eur Heart J 33 2012 579 586
10. K. Thygesen, J. Mair, and E. Giannitsis How to use high-sensitivity cardiac troponins in acute cardiac care Eur Heart J 33 2012 2252 2257
11. E.M. Antman The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making JAMA 284 2000 835 842
12. S.W. Goodacre, M. Bradburn, and E. Cross The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: A randomised controlled trial of point-of-care cardiac markers in the emergency department Heart 97 2011 190 196
13. T. Reichlin, A. Irfan, and R. Twerenbold Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction Circulation 124 2011 136 145
14. R.V. Luepker, F.S. Apple, and R.H. Christenson Case definitions for acute coronary heart disease in epidemiology and clinical research studies: A statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute Circulation 108 2003 2543 2549
15. L. Cullen, M. Than, and A.F. Brown Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia Emerg Med Australas 22 2010 35 55
16. E.A. Amsterdam, J.D. Kirk, and D.A. Bluemke Testing of low-risk patients presenting to the emergency department with chest pain: A scientific statement from the American Heart Association Circulation 122 2010 1756 1776
17. K. Thygesen, J.S. Alpert, and H.D. White Universal definition of myocardial infarction Circulation 116 2007 2634 2653
18. F.S. Apple, and P.O. Collinson Analytical characteristics of high-sensitivity cardiac troponin assays Clin Chem 58 2012 54 61
19. P.A. Kavsak, A.R. MacRae, M.J. Yerna, and A.S. Jaffe Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury Clin Chem 55 2009 573 577
20. G. Koerbin, J. Tate, J.M. Potter, J. Cavanaugh, N. Glasgow, and P.E. Hickman Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population Clin Chem Lab Med 50 2012 871 878
21. S.J. Aldous, M.A. Richards, L. Cullen, R. Troughton, and M. Than A new improved accelerated diagnostic protocol safely identifies low-risk patients with chest pain in the emergency department Acad Emerg Med 19 2012 510 516
22. F.X. Scheuermeyer, J. Christenson, G. Innes, B. Boychuk, E. Yu, and E. Grafstein Safety of assessment of patients with potential ischemic chest pain in an emergency department waiting room: A prospective comparative cohort study Ann Emerg Med 56 2010 455 462
23. K. Thygesen, J.S. Alpert, and H.D. White Universal definition of myocardial infarction Circulation 116 2007 2634 2653
24. K. Thygesen, J. Mair, and E. Giannitsis How to use high-sensitivity cardiac troponins in acute cardiac care Eur Heart J 33 2012 2252 2257
25. S. Eriksson, H. Halenius, K. Pulkki, J. Hellman, and K. Pettersson Negative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies Clin Chem 51 2005 839 847
26. M. Panteghini A critical appraisal of experimental factors influencing the definition of the 99th percentile limit for cardiac troponins Clin Chem Lab Med 47 2009 1179 1182
27. C. Meune, T. Reichlin, and A. Irfan How safe is the outpatient management of patients with acute chest pain and mildly increased cardiac troponin concentrations? Clin Chem 58 2012 916 924
28. M.C. Meyer, R.P. Mooney, and A.K. Sekera A critical pathway for patients with acute chest pain and low risk for short-term adverse cardiac events: Role of outpatient stress testing Ann Emerg Med 47 2006 435.e1 435.e3