Acceptable analytical variation may exceed high-sensitivity cardiac troponin i cutoffs in early rule-out and rule-in acute myocardial infarction algorithms

Clinical Chemistry

Volumn 62, Issue 6, 2016, Pages 887-889

  Kavsak, Peter A ^a   Don Wauchope, Andrew C ^a   Hill, Stephen A ^a   Worster, Andrew ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN I;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ALGORITHM; EMERGENCY WARD; HIGH RISK POPULATION; HUMAN; LETTER; AGED; BLOOD; FEMALE; HEART INFARCTION; MALE; PATHOPHYSIOLOGY; THORAX PAIN;

AGED; ALGORITHMS; CHEST PAIN; FEMALE; HUMANS; MALE; MYOCARDIAL INFARCTION; TROPONIN I;

EID: 84971321387     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2016.255448     Document Type: Letter

References (5)

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2. Kavsak PA. High-five for high-sensitivity cardiac troponin T: depends on the precision and analytical platform. JAMA Intern Med 2013;173:477.
3. Simpson AJ, Porter JM, Koerbin G, Oakman C, Cullen L, Wilkes GJ, et al. Use ofobserved within-person variation of cardiac troponin in emergency department patients for determination of biological variation and percentage and absolute reference change values. Clin Chem 2014;60:848-54.
4. Kavsak PA, Beattie J, Pickersgill R, Ford L, Caruso N, Clark L. A practical approach for the validation and clinical implementation of a high-sensitivity cardiac troponin I assay across a North American city. Pract Lab Med 2015;1:28-34.
5. Simons J, Beach L, Clark L, Kavsak PA. Matrix and bilirubin interference for high-sensitivity cardiac troponin I. Clin Chim Acta 2015;442:49-51.