Structural characterization of fibrils from recombinant human islet amyloid polypeptide by solid-state NMR: The central FGAILS segment is part of the β-sheet core

PLoS ONE

Volumn 11, Issue 9, 2016, Pages

  Weirich, Franziska ^a,b   Gremer, Lothar ^a,b   Mirecka, Ewa A ^b   Schiefer, Stephanie ^b   Hoyer, Wolfgang ^a,b   Heise, Henrike ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CARBON 13; NITROGEN 15; RECOMBINANT PROTEIN; AMYLOID;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; DISULFIDE BOND; FIBER; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; ATOMIC FORCE MICROSCOPY; CHEMISTRY; COLD; DIFFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY; REVERSED PHASE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

AMYLOID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; COLD TEMPERATURE; DIFFUSION; HUMANS; ISLET AMYLOID POLYPEPTIDE; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ATOMIC FORCE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84992125283     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0161243     Document Type: Article

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