Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Diabetologia

Volumn 60, Issue 1, 2017, Pages 98-106

  Brahimaj, Adela ^a   Muka, Taulant ^a   Kavousi, Maryam ^a   Laven, Joop S E ^a   Dehghan, Abbas ^a   Franco, Oscar H ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Androstenedione; DHEA; DHEAS; Food supplement; Independent marker; Type 2 diabetes

Indexed keywords

ANDROSTENEDIONE; ANTILIPEMIC AGENT; C REACTIVE PROTEIN; CHOLESTEROL; ESTRADIOL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROTROPIN; TRIACYLGLYCEROL;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; DIET RESTRICTION; DISEASE ASSOCIATION; DRUG USE; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; DIABETES MELLITUS, TYPE 2; METABOLISM; RISK FACTOR;

AGED; ANDROSTENEDIONE; COHORT STUDIES; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 84992070742     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4136-8     Document Type: Article

References (50)

1. Orentreich N, Brind JL, Rizer RL, Vogelman JH (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59:551–555
2. DeFronzo RA (1981) Glucose intolerance and aging. Diabetes Care 4:493–501
3. Morales AJ, Nolan JJ, Nelson JC, Yen SS (1994) Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 78:1360–1367
4. Yen SS, Morales AJ, Khorram O (1995) Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 774:128–142
5. Lasco A, Frisina N, Morabito N et al (2001) Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol 145:457–461
6. Jakubowicz D, Beer N, Rengifo R (1995) Effect of dehydroepiandrosterone on cyclic-guanosine monophosphate in men of advancing age. Ann N Y Acad Sci 774:312–315
7. Coleman DL, Leiter EH, Schwizer RW (1982) Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes 31:830–833
8. Byrne JJ, Bradlow HL (2001) DHEA-PC slows the progression of type 2 diabetes (non-insulin-dependent diabetes mellitus) in the ZDF/Gmi-fa/fa rat. Diabetes Technol Ther 3:211–219
9. Villareal DT, Holloszy JO (2004) Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA 292:2243–2248
10. Nestler JE, Clore JN, Strauss JF 3rd, Blackard WG (1987) The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. J Clin Endocrinol Metab 64:180–184
11. Dhatariya K, Bigelow ML, Nair KS (2005) Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes 54:765–769
12. Nestler JE, Barlascini CO, Clore JN, Blackard WG (1988) Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66:57–61
13. Basu R, Dalla Man C, Campioni M et al (2007) Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes 56:753–766
14. Kawano H, Yasue H, Kitagawa A et al (2003) Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 88:3190–3195
15. Moran C, Arriaga M, Arechavaleta-Velasco F, Moran S (2015) Adrenal androgen excess and body mass index in polycystic ovary syndrome. J Clin Endocrinol Metab 100:942–950
16. Haffner SM, Valdez RA, Mykkanen L, Stern MP, Katz MS (1994) Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 43:599–603
17. Kalyani RR, Franco M, Dobs AS et al (2009) The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab 94:4127–4135
18. Ding EL, Song Y, Manson JE, Rifai N, Buring JE, Liu S (2007) Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study. Diabetologia 50:2076–2084
19. Veronese N, Trevisan C, De Rui M et al (2016) Serum dehydroepiandrosterone sulfate and risk for type 2 diabetes in older men and women: the Pro.V.A Study. Can J Diabetes 40:158–163
20. Nair KS, Rizza RA, O'Brien P et al (2006) DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 355:1647–1659
21. Hofman A, Brusselle GG, Darwish Murad S et al (2015) The Rotterdam Study: 2016 objectives and design update. Eur J Epidemiol 30:661–708
22. Leening MJ, Kavousi M, Heeringa J et al (2012) Methods of data collection and definitions of cardiac outcomes in the Rotterdam Study. Eur J Epidemiol 27:173–185
23. WH Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. World Health Organization, Geneva
24. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502
25. Caspersen CJ, Bloemberg BP, Saris WH, Merritt RK, Kromhout D (1991) The prevalence of selected physical activities and their relation with coronary heart disease risk factors in elderly men: the Zutphen Study, 1985. Am J Epidemiol 133:1078–1092
26. Ainsworth BE, Haskell WL, Herrmann SD et al (2011) 2011 Compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 43:1575–1581
27. Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65:1220S–1228S, discussion 1229S-1231S
28. Haibe-Kains B, Desmedt C, Sotiriou C, Bontempi G (2008) A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all? Bioinformatics 24:2200–2208
29. Wilson PW, Meigs JB, Sullivan L, Fox CS, Nathan DM, D'Agostino RB Sr (2007) Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med 167:1068–1074
30. Ding EL, Song Y, Malik VS, Liu S (2006) Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 295:1288–1299
31. Mather KJ, Kim C, Christophi CA et al (2015) Steroid sex hormones, sex hormone-binding globulin, and diabetes incidence in the Diabetes Prevention Program. J Clin Endocrinol Metab 100:3778–3786
32. Baulieu EE (1996) Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metab 81:3147–3151
33. Schwartz AG, Pashko LL (1995) Cancer prevention with dehydroepiandrosterone and non-androgenic structural analogs. J Cell Biochem Suppl 22:210–217
34. Khorram O, Vu L, Yen SS (1997) Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A Biol Sci Med Sci 52:M1–M7
35. Watson RR, Huls A, Araghinikuam M, Chung S (1996) Dehydroepiandrosterone and diseases of aging. Drugs Aging 9:274–291
36. Sapolsky RM, Vogelman JH, Orentreich N, Altmann J (1993) Senescent decline in serum dehydroepiandrosterone sulfate concentrations in a population of wild baboons. J Gerontol 48:B196–B200
37. Mortola JF, Yen SS (1990) The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 71:696–704
38. Tenenbaum A, Motro M, Fisman EZ et al (2004) Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation 109:2197–2202
39. Casson PR, Hornsby PJ, Buster JE (1996) Adrenal androgens, insulin resistance, and cardiovascular disease. Semin Reprod Endocrinol 14:29–34
40. Nestler JE (1995) Regulation of human dehydroepiandrosterone metabolism by insulin. Ann N Y Acad Sci 774:73–81
41. Perrini S, Natalicchio A, Laviola L et al (2004) Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes 53:41–52
42. Brignardello E, Runzo C, Aragno M et al (2007) Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients. Diabetes Care 30:2922–2927
43. Ishizuka T, Kajita K, Miura A et al (1999) DHEA improves glucose uptake via activations of protein kinase C and phosphatidylinositol 3-kinase. Am J Physiol 276:E196–E204
44. Pinkney JH, Stehouwer CD, Coppack SW, Yudkin JS (1997) Endothelial dysfunction: cause of the insulin resistance syndrome. Diabetes 46(Suppl 2):S9–S13
45. Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO (2011) Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY) 3:533–542
46. Zumoff BV, Bradlow HL (1980) Sex difference in the metabolism of dehydroisoandrosterone sulfate. J Clin Endocrinol Metab 51:334–336
47. O'Reilly MW, Taylor AE, Crabtree NJ et al (2014) Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione. J Clin Endocrinol Metab 99:1027–1036
48. Rosenfeld RS, Rosenberg BJ, Fukushima DK, Hellman L (1975) 24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate. J Clin Endocrinol Metab 40:850–855
49. Longcope C (1996) Dehydroepiandrosterone metabolism. J Endocrinol 150(Suppl):S125–S127
50. Hucklebridge F, Hussain T, Evans P, Clow A (2005) The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening. Psychoneuroendocrinology 30:51–57