Spinal cord injury induces astroglial conversion towards neuronal lineage

Molecular Neurodegeneration

Volumn 11, Issue 1, 2016, Pages 1-15

  Noristani, Harun Najib ^a,b,c,d   Sabourin, Jean Charles ^e   Boukhaddaoui, Hassan ^d   Chan Seng, Emilie ^e,f   Gerber, Yannick Nicolas ^a,b,c,e   Perrin, Florence Evelyne ^a,b,c,d,e  

^a UNIV MONTPELLIER   (France)

^b University of Montpellier   (France)

^c PSL RESEARCH UNIVERSITY   (France)

^d Montpellier University Medical Center   (France)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^f GUI DE CHAULIAC HOSPITAL   (France)

Author keywords

Astrocytes; Astrogliosis; Cell specific transcriptomic; Spinal cord injury; Transdifferentiation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID RECEPTOR; BETA TUBULIN; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; DOUBLECORTIN; FIBROBLAST GROWTH FACTOR RECEPTOR 4; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEUTROPHIL COLLAGENASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SOX10; GLIAL FIBRILLARY ACIDIC PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; C4A GENE; C4B GENE; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CHI3L3 GENE; CONTROLLED STUDY; CX47 GENE; DISEASE SEVERITY; DOWN REGULATION; GABRA1 GENE; GENE; GFAP GENE; MBP GENE; MMP8 GENE; MOG GENE; MOUSE; NEFL GENE; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PROTEIN EXPRESSION; RSNB GENE; SERPINA3N GENE; SNAP25 GENE; SOX10 GENE; SPINAL CORD INJURY; SYT1 GENE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DISEASE MODEL; METABOLISM; MICROGLIA; NEURAL STEM CELL; PHYSIOLOGY;

ANIMALS; ASTROCYTES; CELL LINEAGE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; MICROGLIA; NEURAL STEM CELLS; SPINAL CORD INJURIES;

EID: 84992065284     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-016-0133-0     Document Type: Article

References (28)

1. Fawcett JW, Asher RA. The glial scar and central nervous system repair. Brain Res Bull. 1999;49:377-91.
2. Karimi-Abdolrezaee S, Billakanti R. Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects. Mol Neurobiol. 2012;46:251-64.
3. Brambilla R, Hurtado A, Persaud T, Esham K, Pearse DD, Oudega M, Bethea JR. Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury. J Neurochem. 2009;110:765-78.
4. Kim JH, Min KJ, Seol W, Jou I, Joe EH. Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses. J Neurochem. 2010;115:1161-71.
5. Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, Ao Y, Sofroniew MV. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci. 2013;33:12870-86.
6. Beutner C, Linnartz-Gerlach B, Schmidt SV, Beyer M, Mallmann MR, Staratschek-Jox A, Schultze JL, Neumann H. Unique transcriptome signature of mouse microglia. Glia. 2013;61:1429-42.
7. Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, et al. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013;4:385-401.
8. Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang LC, Means TK, El Khoury J. The microglial sensome revealed by direct RNA sequencing. Nat Neurosci. 2013;16:1896-905.
9. Huang C, Huang B, Bi F, Yan LH, Tong J, Huang J, Xia XG, Zhou H. Profiling the genes affected by pathogenic TDP-43 in astrocytes. J Neurochem. 2014;129:932-9.
10. Noristani HN, Sabourin JC, Gerber YN, Teigell M, Sommacal A, Vivanco M, Weber M, Perrin FE. Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS. Mol Neurodegener. 2015;10:34.
11. Olah M, Amor S, Brouwer N, Vinet J, Eggen B, Biber K, Boddeke HW. Identification of a microglia phenotype supportive of remyelination. Glia. 2012;60:306-21.
12. Parakalan R, Jiang B, Nimmi B, Janani M, Jayapal M, Lu J, Tay SS, Ling EA, Dheen ST. Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain. BMC Neurosci. 2012;13:64.
13. Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, et al. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging. 2011;32:1795-807.
14. Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA. Genomic analysis of reactive astrogliosis. J Neurosci. 2012;32:6391-410.
15. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, et al. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci. 2008;28:264-78.
16. Noristani HN, Lonjon N, Cardoso M, Le Corre M, Chan-Seng E, Captier G, Privat A, Coillot C, Goze-Bac C, Perrin FE. Correlation of in vivo and ex vivo (1)H-MRI with histology in two severities of mouse spinal cord injury. Front Neuroanat. 2015;9:24.
17. Limke TL, Cai J, Miura T, Rao MS, Mattson MP. Distinguishing features of progenitor cells in the late embryonic and adult hippocampus. Dev Neurosci. 2003;25:257-72.
18. Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009;32:638-47.
19. Wanner IB, Mahoney J, Jessen KR, Wood PM, Bates M, Bunge MB. Invariant mantling of growth cones by Schwann cell precursors characterize growing peripheral nerve fronts. Glia. 2006;54:424-38.
20. White RE, McTigue DM, Jakeman LB. Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice. J Comp Neurol. 2010;518:1370-90.
21. Magnusson JP, Goritz C, Tatarishvili J, Dias DO, Smith EM, Lindvall O, Kokaia Z, Frisen J. A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science. 2014;346:237-41.
22. Su Z, Niu W, Liu ML, Zou Y, Zhang CL. In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun. 2014;5:3338.
23. Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G. In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell. 2014;14:188-202.
24. Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, et al. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. Cell Stem Cell. 2013;12:426-39.
25. Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Bjorklund A, Grealish S, Parmar M. Generation of induced neurons via direct conversion in vivo. Proc Natl Acad Sci U S A. 2013;110:7038-43.
26. Guillemot F, Zimmer C. From cradle to grave: the multiple roles of fibroblast growth factors in neural development. Neuron. 2011;71:574-88.
27. Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development. 2007;134:2895-902.
28. Feng GD, He BR, Lu F, Liu LH, Zhang L, Chen B, He ZP, Hao DJ, Yang H. Fibroblast growth factor 4 is required but not sufficient for the astrocyte dedifferentiation. Mol Neurobiol. 2014;50:997-1012.