Serotonin-1A receptor alterations in depression: A meta-analysis of molecular imaging studies

BMC Psychiatry

Volumn 16, Issue 1, 2016, Pages

  Wang, Ling ^a   Zhou, Chanjuan ^a,b   Zhu, Dan ^a,b   Wang, Xinfa ^a   Fang, Liang ^a   Zhong, Jiaju ^a   Mao, Qiang ^a   Sun, Lu ^a   Gong, Xue ^a   Xia, Jinjun ^a   Lian, Bing ^a   Xie, Peng ^a,b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

5 HT1A; Depression; Meta analysis; Molecular imaging

Indexed keywords

SEROTONIN 1A RECEPTOR; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN;

AMYGDALA; ANTERIOR CINGULATE; ARTICLE; BRAIN CORTEX; DEPRESSION; HIPPOCAMPUS; HUMAN; INSULA; MESIOTEMPORAL CORTEX; MOLECULAR IMAGING; NEUROTRANSMISSION; OBSERVATIONAL STUDY; OCCIPITAL CORTEX; PATHOGENESIS; POSITRON EMISSION TOMOGRAPHY; PROTEIN BINDING; RAPHE NUCLEUS; SEROTONINERGIC SYSTEM; SYSTEMATIC REVIEW; ADULT; CINGULATE GYRUS; FEMALE; MALE; META ANALYSIS; METABOLISM; NEUROIMAGING; PROCEDURES;

ADULT; AMYGDALA; CEREBRAL CORTEX; DEPRESSION; DEPRESSIVE DISORDER; FEMALE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; MALE; MOLECULAR IMAGING; NEUROIMAGING; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RAPHE NUCLEI; SEROTONIN;

EID: 84992027498     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/s12888-016-1025-0     Document Type: Article

References (49)

1. Agren H, Reibring L, Hartvig P, Tedroff J, Bjurling P, Hornfeldt K, Andersson Y, Lundqvist H, Langstrom B. Low brain uptake of L-[11C]5-hydroxytryptophan in major depression: a positron emission tomography study on patients and healthy volunteers. Acta Psychiatr Scand. 1991;83:449-55.
2. Albert PR, Lembo P, Storring JM, Charest A, Saucier C. The 5-HT1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology. 1996;14:19-25.
3. Baldessarini RJ. The basis for amine hypotheses in affective disorders. A critical evaluation. Arch Gen Psychiatry. 1975;32:1087-93.
4. 11C]WAY-100635. Mol Psychiatry. 2004;9:386-92.
5. Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A, Matthews PM, Cowen PJ. Reduction in occipital cortex γ-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry. 2007;61:806-12.
6. Billard T, Le Bars D, Zimmer L. PET radiotracers for molecular imaging of serotonin 5-HT1A receptors. Curr Med Chem. 2014;21:70-81.
7. Boldrini M, Underwood MD, Mann JJ, Arango V. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res. 2008;42:433-42.
8. Campbell S, MacQueen G. The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci. 2004;29:417.
9. Checkley S. The neuroendocrinology of depression and chronic stress. Br Med Bull. 1996;52:597-617.
10. Collin M, Håkansson-Ovesjö ML, Misane I, Ogren SO, Meister B. Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. Mol Brain Res. 2000;81:51-61.
11. Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, Huang Y, Gautier C, Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry. 1999;46:1375-87.
12. Farde L, Ginovart N, Ito H, Lundkvist C, Pike VW, McCarron JA, Halldin C. PET-characterization of [carbonyl-11C]WAY-100635 binding to 5-HT1A receptors in the primate brain. Psychopharmacology (Berl). 1997;133(2):196-202.
13. Graeff FG, Guimarães FS, De Andrade TG, Deakin JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav. 1996;54:129-41.
14. Gryglewski G. Meta-analysis of molecular imaging of serotonin transporters in major depression. J Cereb Blood Flow Metab. 2014;34(7):1096-103.
15. Haddjeri N, Blier P, de Montigny C. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J Neurosci. 1998;18:10150-6.
16. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistencyin meta-analyses. BMJ. 2003;327(7414):557-60.
17. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions, VolumeVersion 5.1.0. 2011. Available from http://handbook.cochrane.org/.
18. 11C]WAY-100635. Int J Neuropsychopharmacol. 2008;11:465-76.
19. Hong C, Chen T, Yu YW, Tsa S. Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J. 2005;6:27-33.
20. Karlsson H, Hirvonen J, Salminen JK, Hietala J. No association between serotonin 5-HT 1A receptors and spirituality among patients with major depressive disorders or healthy volunteers. Mol Psychiatry. 2011;16:282-5.
21. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008;455:894-902.
22. Lan MJ, Hesselgrave N, Ciarleglio A, Ogden RT, Sullivan GM, Mann JJ, Parsey RV. Higher pretreatment 5-HT1A receptor binding potential in bipolar disorder depression is associated with treatment remission: A naturalistic treatment pilot PET study. Synapse. 2013;67:773-8.
23. Lanzenberger R, Baldinger P, Hahn A, Ungersboeck J, Mitterhauser M, Winkler D, Micskei Z, Stein P, Karanikas G, Wadsak W, Kasper S, Frey R. Global decrease of serotonin-1A receptor binding after electroconvulsive therapy in major depression measured by PET. Mol Psychiatry. 2013;18:93-100.
24. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003;23:8788-99.
25. Lesch KP, Söhnle K, Poten B, Schoellnhammer G, Rupprecht R, Schulte HM. Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and β-adrenoceptor antagonists. J Clin Endocrinol Metab. 1990;70:670-4.
26. Lowther S, De Paermentier F, Cheetham SC, Crompton MR, Katona CL, Horton RW. 5-HT1A Receptor binding sites in post-mortem brain samples from depressed suicides and controls. J Affect Disord. 1997;42:199-207.
27. Matsubara S, Arora R, Meltzer HY. Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims. J Neural Transm Gen Sect. 1991;85:181-94.
28. Meltzer CC, Price JC, Mathis CA, Butters MA, Ziolko SK, Moses-Kolko E, Mazumdar S, Mulsan BH, Houck PR, Lopresti BJ, Weissfeld LA, Reynolds CF. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology. 2004;29:2258-65.
29. Mervaala E, Föhr J, Könönen M, Valkonen-Korhonen M, Vainio P, Partanen K, Partanen J, Tiihonen J, Viinamäki H, Karjalainen AK. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med. 2000;30:117-25.
30. Michelsen KA, Schmitz C, Steinbusch HW. The dorsal raphe nucleus-from silver stainings to a role in depression. Brain Res Rev. 2007;55:329-42.
31. Miller JM, Brennan KG, Ogden TR, Oquendo MA, Sullivan GM, Mann JJ, Parsey RV. Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality. Neuropsychopharmacology. 2009;34:2275-84.
32. Miller JM, Hesselgrave N, Ogden RT, Zanderigo F, Oquendo MA, Mann JJ, Parsey RV. Brain serotonin 1A receptor binding as a predictor of treatment outcome in major depressive disorder. Biol Psychiatry. 2013;74(10):760-7. doi: 10.1016/j.biopsych.2013.03.021. Epub 2013 May 9.
33. Moses-Kolko EL, Wisner KL, Price JC, Berga SL, Drevets WC, Hanusa BH, Loucks TL, Meltzer CC. Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. Fertil Steril. 2008;89:685-92.
34. Nugent AC, Bain EE, Carlson PJ, Neumeister A, Bonne O, Carson RE, Eckelman W, Herscovitch P, Zarate Jr CA, Charney DS. Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression. Eur Neuropsychopharmacol. 2013;23:822-9.
35. Nugent AC, Carlson PJ, Bain EE, Eckelman W, Herscovitch P, Manji H, Zarate CA, Drevets WC. Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression. J Psychopharmacol. 2013;27:894-902.
36. Ögren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O. The role of 5-HT1A receptors in learning and memory. Behav Brain Res. 2008;195:54-77.
37. Palchaudhuri M, Flügge G. 5-HT1A receptor expression in pyramidal neurons of cortical and limbic brain regions. Cell Tissue Res. 2005;321:159-72.
38. Parsey RV, Hastings RS, Oquendo MA, Huang YY, Simpson N, Arcement J, Huang Y, Ogden RT, Van Heertum RL, Arango V. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatr. 2006;163:52-8.
39. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, Van Heertum RL, Arango V, Mann JJ. Altered serotonin 1A binding in major depression: A [carbonyl-C-11] WAY100635 positron emission tomography study. Biol Psychiatry. 2006;59:106-13.
40. Polter AM, Li X. 5-HT1A receptor-regulated signal transduction pathways in brain. Cell Signal. 2010;22:1406-12.
41. Radley JJ, Jacobs BL. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Res. 2002;955:264-7.
42. Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety. 2000;12:2-19.
43. 11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry. 2000;57:174-80.
44. Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced cortical γ-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 1999;56:1043-7.
45. Shrestha S, Hirvonen J, Hines CS, Henter ID, Svenningsson P, Pike VW, Innis RB. Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations. NeuroImage. 2012;59:3243-51.
46. Strobel A, Gutknecht L, Rothe C, Reif A, Mössner R, Zeng Y, Brocke B, Lesch KP. Allelic variation in 5-HT1A receptor expression is associated with anxiety-and depression-related personality traits. J Neural Transm. 2003;110:1445-53.
47. Stroup D.F, Berlin J.A, Morton S.C, Olkin I, Williamson G.D, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. JAMA. 2000;283(15):2008-12. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008-12.
48. Sullivan GM, Ogden RT, Oquendo MA, Kumar JSD, Simpson N, Huang YY, Mann JJ, Parsey RV. Positron Emission Tomography Quantification of Serotonin-1A Receptor Binding in Medication-Free Bipolar Depression. Biol Psychiatry. 2009;66:223-30.
49. Wu Y, Xu Y, Sun Y, Wang YF, Li X, Lang XE, Wang WP, Zhang KR. Association between the serotonin 1A receptor C (-1019) G polymorphism and major depressive disorder in the northern Han ethnic group in China. Chin Med J. 2008;121:874.