Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy

Journal of the Royal Society Interface

Volumn 11, Issue 99, 2014, Pages

  Sun, Wei ^a   Lim, Chwee Teck ^b,c,d   Kurniawan, Nicholas Agung ^e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Department of Biomedical Engineering ^*  (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e FOM INSTITUTE AMOLF   (Netherlands)

Author keywords

Cancer metastasis; Drug assay; Extracellular matrix mechanics; Threedimensional cell migration

Indexed keywords

ASSAYS; COMPUTER ARCHITECTURE; CYTOLOGY; DIAGNOSIS; DISEASES; ENZYME INHIBITION; GELS; HYDROGELS; PATHOLOGY; TUMORS;

BIOPHYSICAL PROPERTIES; BREAST CANCER CELLS; CANCER METASTASIS; CELL MIGRATION; EXTRACELLULAR MATRICES; FUNCTIONAL ASSAYS; MICRO ARCHITECTURES; MOLECULAR MECHANISM;

CELLS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANTIMETASTATIC AGENT; COLLAGEN GEL; CYTOCHALASIN D; ILOMASTAT; NOCODAZOLE; AMIDE; ANTINEOPLASTIC AGENT; DIPEPTIDE; HYDROGEL; N-(2(R)-2-(HYDROXAMIDOCARBONYLMETHYL)-4-METHYLPENTANOYL)-L-TRYPTOPHAN METHYLAMIDE; PYRIDINE DERIVATIVE;

ARTICLE; BREAST CANCER CELL LINE; CANCER CELL; CELL INVASION; CELL PH; CELL SPREADING; CONTROLLED STUDY; CYTOARCHITECTURE; DRUG EFFICACY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROGEL; METASTASIS; POLYMERIZATION; PROTEIN CONTENT; PROTEIN DEGRADATION; TUMOR INVASION; YOUNG MODULUS; BREAST NEOPLASMS; CELL MOTION; CONFOCAL MICROSCOPY; DRUG EFFECTS; FEMALE; METABOLISM; NEOPLASM METASTASIS; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; TIME LAPSE IMAGING; TUMOR EMBOLISM;

AMIDES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL MOVEMENT; CYTOCHALASIN D; DIPEPTIDES; EXTRACELLULAR MATRIX; FEMALE; HUMANS; HYDROGEL; MICROSCOPY, CONFOCAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; NOCODAZOLE; PYRIDINES; STATISTICS, NONPARAMETRIC; TIME-LAPSE IMAGING;

EID: 84992008674     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2014.0638     Document Type: Article

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