A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

Virology

Volumn 499, Issue , 2016, Pages 375-382

  Tai, Wanbo ^a,b   Zhao, Guangyu ^a   Sun, Shihun ^a   Guo, Yan ^a   Wang, Yufei ^a,b   Tao, Xinrong ^c   Tseng, Chien Te K ^c   Li, Fang ^d   Jiang, Shibo ^b,e   Du, Lanying, ^b   Zhou, Yusen ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b NEW YORK BLOOD CENTER   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e FUDAN UNIVERSITY   (China)

Author keywords

Foldon trimerization motif; hDPP4 transgenic mice; MERS; MERS CoV; Neutralization; Protection; Receptor binding domain; Spike protein

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; NEUTRALIZING ANTIBODY; VIRUS SPIKE PROTEIN; VIRUS VACCINE; CORONAVIRUS SPIKE GLYCOPROTEIN; DPP4 PROTEIN, HUMAN; DPP4 PROTEIN, MOUSE; PROTEIN BINDING; VIRUS ANTIBODY; VIRUS RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; FEMALE; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; RECEPTOR BINDING; TRANSGENIC MOUSE; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CORONAVIRUS INFECTIONS; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PROTEIN BINDING; PROTEIN DOMAINS; RECEPTORS, VIRUS; SPIKE GLYCOPROTEIN, CORONAVIRUS;

EID: 84991782470     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2016.10.005     Document Type: Article

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