메뉴 건너뛰기




Volumn 51, Issue 12, 2016, Pages 1407-1415

The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis

Author keywords

clinical trials; Crohn s disease; dysbiosis; faecal microbiota; Ulcerative colitis

Indexed keywords

BIFIDOBACTERIUM; CLOSTRIDIUM; CLOSTRIDIUM COCCOIDES; CLOSTRIDIUM LEPTUM; CROHN DISEASE; DENATURING GRADIENT GEL ELECTROPHORESIS; DISEASE ACTIVITY; ESCHERICHIA COLI; FAECALIBACTERIUM PRAUSNITZII; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; INTESTINE FLORA; LACTOBACILLUS; META ANALYSIS; NEWCASTLE OTTAWA SCALE; NONHUMAN; NUCLEIC ACID ANALYSIS; POPULATION ABUNDANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RATING SCALE; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SYSTEMATIC REVIEW; TERMINAL RESTRICTION FRACTION LENGTH POLYMORPHISM; ULCERATIVE COLITIS; DYSBIOSIS; FAECALIBACTERIUM; FECES; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOPHYSIOLOGY;

EID: 84991712942     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365521.2016.1216587     Document Type: Review
Times cited : (167)

References (56)
  • 1
    • 84944905654 scopus 로고    scopus 로고
    • Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease
    • J.Babickova, R.Gardlik Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease. World J Gastroenterol. 2015;21:11321–11330.
    • (2015) World J Gastroenterol , vol.21 , pp. 11321-11330
    • Babickova, J.1    Gardlik, R.2
  • 2
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: current status and the future ahead
    • A.D.Kostic, R.J.Xavier, D.Gevers The microbiome in inflammatory bowel disease:current status and the future ahead. Gastroenterology. 2014;146:1489–1499.
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 3
    • 84899907895 scopus 로고    scopus 로고
    • Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy
    • M.K.Vester-Andersen, M.V.Prosberg, T.Jess,. Disease course and surgery rates in inflammatory bowel disease:a population-based, 7-year follow-up study in the era of immunomodulating therapy. Am J Gastroenterol. 2014;109:705–714.
    • (2014) Am J Gastroenterol , vol.109 , pp. 705-714
    • Vester-Andersen, M.K.1    Prosberg, M.V.2    Jess, T.3
  • 4
    • 33744783677 scopus 로고    scopus 로고
    • Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003–2005: a population-based study from the Danish Crohn colitis database
    • I.Vind, L.Riis, T.Jess,. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003–2005:a population-based study from the Danish Crohn colitis database. Am J Gastroenterol. 2006;101:1274–1282.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1274-1282
    • Vind, I.1    Riis, L.2    Jess, T.3
  • 6
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • W.Strober, I.Fuss, P.Mannon The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117:514–521.
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 7
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • B.Khor, A.Gardet, R.J.Xavier Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307–317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 8
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • S.R.Gill, M.Pop, R.T.Deboy,. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312:1355–1359.
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1    Pop, M.2    Deboy, R.T.3
  • 9
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • L.Jostins, S.Ripke, R.K.Weersma,. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119–124.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 10
    • 0028003794 scopus 로고
    • The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
    • J.D.Taurog, J.A.Richardson, J.T.Croft,. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med. 1994;180:2359–2364.
    • (1994) J Exp Med , vol.180 , pp. 2359-2364
    • Taurog, J.D.1    Richardson, J.A.2    Croft, J.T.3
  • 11
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • R.K.Sellon, S.Tonkonogy, M.Schultz,. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998;66:5224–5231.
    • (1998) Infect Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3
  • 12
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • D.N.Frank, A.L.St Amand, R.A.Feldman,. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA. 2007;104:13780–13785.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3
  • 13
    • 33645019411 scopus 로고    scopus 로고
    • Specificities of the fecal microbiota in inflammatory bowel disease
    • H.Sokol, P.Seksik, L.Rigottier-Gois,. Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12:106–111.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 106-111
    • Sokol, H.1    Seksik, P.2    Rigottier-Gois, L.3
  • 14
    • 44649118583 scopus 로고    scopus 로고
    • Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases
    • D.A.Peterson, D.N.Frank, N.R.Pace,. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe. 2008;3:417–427.
    • (2008) Cell Host Microbe , vol.3 , pp. 417-427
    • Peterson, D.A.1    Frank, D.N.2    Pace, N.R.3
  • 15
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • S.J.Ott, M.Musfeldt, D.F.Wenderoth,. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut. 2004;53:685–693.
    • (2004) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1    Musfeldt, M.2    Wenderoth, D.F.3
  • 16
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
    • C.Manichanh, L.Rigottier-Gois, E.Bonnaud,. Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut. 2006;55:205–211.
    • (2006) Gut , vol.55 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3
  • 17
    • 34548483459 scopus 로고    scopus 로고
    • Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn’s disease involving the ileum
    • M.Baumgart, B.Dogan, M.Rishniw,. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn’s disease involving the ileum. ISME J. 2007;1:403–418.
    • (2007) ISME J , vol.1 , pp. 403-418
    • Baumgart, M.1    Dogan, B.2    Rishniw, M.3
  • 18
    • 33750956239 scopus 로고    scopus 로고
    • Differences between tissue-associated intestinal microfloras of patients with Crohn’s disease and ulcerative colitis
    • U.Gophna, K.Sommerfeld, S.Gophna,. Differences between tissue-associated intestinal microfloras of patients with Crohn’s disease and ulcerative colitis. J Clin Microbiol. 2006;44:4136–4141.
    • (2006) J Clin Microbiol , vol.44 , pp. 4136-4141
    • Gophna, U.1    Sommerfeld, K.2    Gophna, S.3
  • 19
    • 0037302961 scopus 로고    scopus 로고
    • Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon
    • P.Seksik, L.Rigottier-Gois, G.Gramet,. Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon. Gut. 2003;52:237–242.
    • (2003) Gut , vol.52 , pp. 237-242
    • Seksik, P.1    Rigottier-Gois, L.2    Gramet, G.3
  • 20
    • 34547684651 scopus 로고    scopus 로고
    • Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    • C.Lupp, M.L.Robertson, M.E.Wickham,. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe. 2007;2:119–129.
    • (2007) Cell Host Microbe , vol.2 , pp. 119-129
    • Lupp, C.1    Robertson, M.L.2    Wickham, M.E.3
  • 21
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
    • A.Liberati, D.G.Altman, J.Tetzlaff,. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions:explanation and elaboration. BMJ. 2009;339:b2700.
    • (2009) BMJ , vol.339 , pp. b2700
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 22
    • 84991705486 scopus 로고    scopus 로고
    • G.A.Wells, B.Shea, D.O’Connell,. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. [cited 2016 Feb 1]. Available from:http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. 2015.
    • (2015)
    • Wells, G.A.1    Shea, B.2    O’Connell, D.3
  • 24
    • 84931469899 scopus 로고    scopus 로고
    • Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial
    • P.Moayyedi, M.G.Surette, P.T.Kim,. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015;149:102–109. e106.
    • (2015) Gastroenterology , vol.149 , pp. 102-109
    • Moayyedi, P.1    Surette, M.G.2    Kim, P.T.3
  • 25
    • 84931423571 scopus 로고    scopus 로고
    • Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • N.G.Rossen, S.Fuentes, M.J.van der Spek,. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology. 2015;149:110–118. e114.
    • (2015) Gastroenterology , vol.149 , pp. 110-118
    • Rossen, N.G.1    Fuentes, S.2    van der Spek, M.J.3
  • 26
    • 84920714102 scopus 로고    scopus 로고
    • Fecal microbial transplant via nasogastric tube for active pediatric ulcerative colitis
    • D.L.Suskind, N.Singh, H.Nielson,. Fecal microbial transplant via nasogastric tube for active pediatric ulcerative colitis. J Pediatr Gastroenterol Nutr. 2015;60:27–29.
    • (2015) J Pediatr Gastroenterol Nutr , vol.60 , pp. 27-29
    • Suskind, D.L.1    Singh, N.2    Nielson, H.3
  • 27
    • 84924351338 scopus 로고    scopus 로고
    • Abnormal fibre usage in UC in remission
    • S.L.James, C.T.Christophersen, A.R.Bird,. Abnormal fibre usage in UC in remission. Gut. 2015;64:562–570.
    • (2015) Gut , vol.64 , pp. 562-570
    • James, S.L.1    Christophersen, C.T.2    Bird, A.R.3
  • 28
    • 84903480840 scopus 로고    scopus 로고
    • Is rifaximin effective in maintaining remission in Crohn’s disease?
    • A.O.Jigaranu, O.Nedelciuc, A.Blaj,. Is rifaximin effective in maintaining remission in Crohn’s disease? Dig Dis. 2014;32:378–383.
    • (2014) Dig Dis , vol.32 , pp. 378-383
    • Jigaranu, A.O.1    Nedelciuc, O.2    Blaj, A.3
  • 29
    • 84879238231 scopus 로고    scopus 로고
    • Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis
    • E.Varela, C.Manichanh, M.Gallart,. Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis. Aliment Pharmacol Ther. 2013;38:151–161.
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 151-161
    • Varela, E.1    Manichanh, C.2    Gallart, M.3
  • 30
    • 84875717908 scopus 로고    scopus 로고
    • Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease
    • A.Andoh, H.Kuzuoka, T.Tsujikawa,. Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease. J Gastroenterol. 2012;47:1298–1307.
    • (2012) J Gastroenterol , vol.47 , pp. 1298-1307
    • Andoh, A.1    Kuzuoka, H.2    Tsujikawa, T.3
  • 31
    • 84893029775 scopus 로고    scopus 로고
    • Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease
    • W.Wang, L.Chen, R.Zhou,. Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. J Clin Microbiol. 2014;52:398–406.
    • (2014) J Clin Microbiol , vol.52 , pp. 398-406
    • Wang, W.1    Chen, L.2    Zhou, R.3
  • 32
    • 84873717548 scopus 로고    scopus 로고
    • The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease
    • S.Sha, B.Xu, X.Wang,. The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease. Diagn Microbiol Infect Dis. 2013;75:245–251.
    • (2013) Diagn Microbiol Infect Dis , vol.75 , pp. 245-251
    • Sha, S.1    Xu, B.2    Wang, X.3
  • 33
    • 84873176222 scopus 로고    scopus 로고
    • Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls
    • L.K.Vigsnaes, J.Brynskov, C.Steenholdt,. Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls. Benef Microbes. 2012;3:287–297.
    • (2012) Benef Microbes , vol.3 , pp. 287-297
    • Vigsnaes, L.K.1    Brynskov, J.2    Steenholdt, C.3
  • 34
    • 39649100206 scopus 로고    scopus 로고
    • Active Crohn’s disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora
    • A.Swidsinski, V.Loening-Baucke, M.Vaneechoutte,. Active Crohn’s disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora. Inflamm Bowel Dis. 2008;14:147–161.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 147-161
    • Swidsinski, A.1    Loening-Baucke, V.2    Vaneechoutte, M.3
  • 35
    • 70349488325 scopus 로고    scopus 로고
    • Low counts of Faecalibacterium prausnitzii in colitis microbiota
    • H.Sokol, P.Seksik, J.P.Furet,. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis. 2009;15:1183–1189.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1183-1189
    • Sokol, H.1    Seksik, P.2    Furet, J.P.3
  • 36
    • 44349164525 scopus 로고    scopus 로고
    • Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease
    • H.Takaishi, T.Matsuki, A.Nakazawa,. Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease. Int J Med Microbiol. 2008;298:463–472.
    • (2008) Int J Med Microbiol , vol.298 , pp. 463-472
    • Takaishi, H.1    Matsuki, T.2    Nakazawa, A.3
  • 37
    • 84879053204 scopus 로고    scopus 로고
    • Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India
    • R.Kumari, V.Ahuja, J.Paul Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India. World J Gastroenterol. 2013;19:3404–3414.
    • (2013) World J Gastroenterol , vol.19 , pp. 3404-3414
    • Kumari, R.1    Ahuja, V.2    Paul, J.3
  • 38
    • 84902150181 scopus 로고    scopus 로고
    • Alterations in the intestinal microbiome (dysbiosis) as a predictor of relapse after infliximab withdrawal in Crohn’s disease
    • S.Rajca, V.Grondin, E.Louis,. Alterations in the intestinal microbiome (dysbiosis) as a predictor of relapse after infliximab withdrawal in Crohn’s disease. Inflamm Bowel Dis. 2014;20:978–986.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 978-986
    • Rajca, S.1    Grondin, V.2    Louis, E.3
  • 39
    • 84882297193 scopus 로고    scopus 로고
    • Association of gut microbiota with post-operative clinical course in Crohn’s disease
    • N.Dey, D.A.Soergel, S.Repo,. Association of gut microbiota with post-operative clinical course in Crohn’s disease. BMC Gastroenterol. 2013;13:131.
    • (2013) BMC Gastroenterol , vol.13 , pp. 131
    • Dey, N.1    Soergel, D.A.2    Repo, S.3
  • 40
    • 84921481734 scopus 로고    scopus 로고
    • Association between specific mucosa-associated microbiota in Crohn’s disease at the time of resection and subsequent disease recurrence: a pilot study
    • P.De Cruz, S.Kang, J.Wagner,. Association between specific mucosa-associated microbiota in Crohn’s disease at the time of resection and subsequent disease recurrence:a pilot study. J Gastroenterol Hepatol. 2015;30:268–278.
    • (2015) J Gastroenterol Hepatol , vol.30 , pp. 268-278
    • De Cruz, P.1    Kang, S.2    Wagner, J.3
  • 41
    • 84874057008 scopus 로고    scopus 로고
    • Longitudinal analyses of gut mucosal microbiotas in ulcerative colitis in relation to patient age and disease severity and duration
    • A.Fite, S.Macfarlane, E.Furrie,. Longitudinal analyses of gut mucosal microbiotas in ulcerative colitis in relation to patient age and disease severity and duration. J Clin Microbiol. 2013;51:849–856.
    • (2013) J Clin Microbiol , vol.51 , pp. 849-856
    • Fite, A.1    Macfarlane, S.2    Furrie, E.3
  • 42
    • 53649108521 scopus 로고    scopus 로고
    • Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse
    • S.J.Ott, S.Plamondon, A.Hart,. Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse. J Clin Microbiol. 2008;46:3510–3513.
    • (2008) J Clin Microbiol , vol.46 , pp. 3510-3513
    • Ott, S.J.1    Plamondon, S.2    Hart, A.3
  • 43
    • 84899627277 scopus 로고    scopus 로고
    • Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes
    • M.Lopez-Siles, M.Martinez-Medina, D.Busquets,. Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes. Int J Med Microbiol. 2014;304:464–475.
    • (2014) Int J Med Microbiol , vol.304 , pp. 464-475
    • Lopez-Siles, M.1    Martinez-Medina, M.2    Busquets, D.3
  • 44
    • 84872791148 scopus 로고    scopus 로고
    • Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India
    • J.Kabeerdoss, V.Sankaran, S.Pugazhendhi,. Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease:a case-control study in India. BMC Gastroenterol. 2013;13:20.
    • (2013) BMC Gastroenterol , vol.13 , pp. 20
    • Kabeerdoss, J.1    Sankaran, V.2    Pugazhendhi, S.3
  • 45
    • 84904048875 scopus 로고    scopus 로고
    • A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
    • K.Machiels, M.Joossens, J.Sabino,. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014;63:1275–1283.
    • (2014) Gut , vol.63 , pp. 1275-1283
    • Machiels, K.1    Joossens, M.2    Sabino, J.3
  • 46
    • 0017227303 scopus 로고
    • Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study
    • W.R.Best, J.M.Becktel, J.W.SingletonJr.,. Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study. Gastroenterology. 1976;70:439–444.
    • (1976) Gastroenterology , vol.70 , pp. 439-444
    • Best, W.R.1    Becktel, J.M.2    Singleton, J.W.3
  • 47
    • 59849104111 scopus 로고    scopus 로고
    • Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis
    • J.D.Lewis, S.Chuai, L.Nessel,. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660–1666.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1660-1666
    • Lewis, J.D.1    Chuai, S.2    Nessel, L.3
  • 48
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • G.Bouma, W.Strober The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521–533.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 49
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease
    • J.P.Hugot, M.Chamaillard, H.Zouali,. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411:599–603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 50
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci
    • A.Franke, D.P.McGovern, J.C.Barrett,. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. Nat Genet. 2010;42:1118–1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 51
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • P.J.Turnbaugh, M.Hamady, T.Yatsunenko,. A core gut microbiome in obese and lean twins. Nature. 2009;457:480–484.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1    Hamady, M.2    Yatsunenko, T.3
  • 52
    • 84884273778 scopus 로고    scopus 로고
    • Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome
    • D.Knights, K.G.Lassen, R.J.Xavier Advances in inflammatory bowel disease pathogenesis:linking host genetics and the microbiome. Gut. 2013;62:1505–1510.
    • (2013) Gut , vol.62 , pp. 1505-1510
    • Knights, D.1    Lassen, K.G.2    Xavier, R.J.3
  • 53
    • 84871569798 scopus 로고    scopus 로고
    • Crohn’s as an immune deficiency: from apparent paradox to evolving paradigm
    • D.C.Vinh, M.A.Behr Crohn’s as an immune deficiency:from apparent paradox to evolving paradigm. Expert Rev Clin Immunol. 2013;9:17–30.
    • (2013) Expert Rev Clin Immunol , vol.9 , pp. 17-30
    • Vinh, D.C.1    Behr, M.A.2
  • 54
    • 84893110419 scopus 로고    scopus 로고
    • Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
    • G.L.Hold, M.Smith, C.Grange,. Role of the gut microbiota in inflammatory bowel disease pathogenesis:what have we learnt in the past 10 years? World J Gastroenterol. 2014;20:1192–1210.
    • (2014) World J Gastroenterol , vol.20 , pp. 1192-1210
    • Hold, G.L.1    Smith, M.2    Grange, C.3
  • 55
    • 84884650652 scopus 로고    scopus 로고
    • Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases
    • V.Leone, E.B.Chang, S.Devkota Diet, microbes, and host genetics:the perfect storm in inflammatory bowel diseases. J Gastroenterol. 2013;48:315–321.
    • (2013) J Gastroenterol , vol.48 , pp. 315-321
    • Leone, V.1    Chang, E.B.2    Devkota, S.3
  • 56
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • D.N.Frank, C.E.Robertson, C.M.Hamm,. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis. 2011;17:179–184.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 179-184
    • Frank, D.N.1    Robertson, C.E.2    Hamm, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.