Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator

Journal of Endocrinological Investigation

Volumn 39, Issue 11, 2016, Pages 1347-1355

  Menzel, J ^a,b,c   Di Giuseppe, R ^d   Biemann, R ^e   Aleksandrova, K ^a   Kuxhaus, O ^a   Wittenbecher, C ^a,c   Fritsche, A ^c,f   Schulze, M B ^a,c   Isermann, B ^e   Boeing, H ^a   Weikert, C ^b,g  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Bone mineral density; Broadband ultrasound attenuation; Intelectin 1; Osteoclastogenesis inhibitory factor

Indexed keywords

ADIPONECTIN; CYTOKINE; OMENTIN 1; OSTEOPROTEGERIN; UNCLASSIFIED DRUG; ADIPOQ PROTEIN, HUMAN; BIOLOGICAL MARKER; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; ITLN1 PROTEIN, HUMAN; LECTIN;

ADULT; ARTICLE; BODY MASS; BONE DENSITY; BONE REMODELING; DIETARY INTAKE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SMOKING; WAIST CIRCUMFERENCE; BLOOD; CONTROLLED STUDY; ECHOGRAPHY; MIDDLE AGED; PREMENOPAUSE; PROCEDURES; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL;

ADIPONECTIN; ADULT; BIOMARKERS; BONE DENSITY; CYTOKINES; FEMALE; GPI-LINKED PROTEINS; HUMANS; LECTINS; MIDDLE AGED; OSTEOPOROSIS; OSTEOPROTEGERIN; POSTMENOPAUSE; PREMENOPAUSE; PROSPECTIVE STUDIES; SURVEYS AND QUESTIONNAIRES; ULTRASONOGRAPHY;

EID: 84991594396     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-016-0544-3     Document Type: Article

References (45)

1. Testa G, Pavone V, Mangano S, Riccioli M, Arancio A, Evola FR, Avonda S, Sessa G (2015) Normal nutritional components and effects on bone metabolism in prevention of osteoporosis. J Biol Regul Homeost Agents 29(3):729–736
2. Lloyd JT, Alley DE, Hawkes WG, Hochberg MC, Waldstein SR, Orwig DL (2014) Body mass index is positively associated with bone mineral density in US older adults. Arch Osteoporos 9:175. doi:10.1007/s11657-014-0175-2
3. Menzel J, di Giuseppe R, Wientzek A, Kroke A, Boeing H, Weikert C (2015) Physical Activity, Bone Health, and Obesity in Peri-/Pre- and Postmenopausal Women: results from the EPIC-Potsdam Study. Calcif Tissue Int 97(4):376–384. doi:10.1007/s00223-015-0027-0
4. Sneve M, Emaus N, Joakimsen RM, Jorde R (2008) The association between serum parathyroid hormone and bone mineral density, and the impact of smoking: the Tromso Study. Eur J Endocrinol/Eur Fed Endocr Soc 158(3):401–409. doi:10.1530/EJE-07-0610
5. Zaidi M, Buettner C, Sun L, Iqbal J (2012) Minireview: the link between fat and bone: does mass beget mass? Endocrinology 153(5):2070–2075. doi:10.1210/en.2012-1022
6. Magni P, Dozio E, Galliera E, Ruscica M, Corsi MM (2010) Molecular aspects of adipokine-bone interactions. Curr Mol Med 10(6):522–532
7. Lubkowska A, Dobek A, Mieszkowski J, Garczynski W, Chlubek D (2014) Adiponectin as a biomarker of osteoporosis in postmenopausal women: controversies. Dis Markers 2014:975178. doi:10.1155/2014/975178
8. Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE (2004) Adiponectin and its receptors are expressed in bone-forming cells. Bone 35(4):842–849. doi:10.1016/j.bone.2004.06.008
9. Biver E, Salliot C, Combescure C, Gossec L, Hardouin P, Legroux-Gerot I, Cortet B (2011) Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab 96(9):2703–2713. doi:10.1210/jc.2011-0047
10. Hadjidakis DJ, Androulakis II (2006) Bone remodeling. Ann N Y Acad Sci 1092:385–396. doi:10.1196/annals.1365.035
11. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I (2005) Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 331(2):520–526. doi:10.1016/j.bbrc.2005.03.210
12. Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP, Liao EY (2005) Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res 309(1):99–109. doi:10.1016/j.yexcr.2005.05.021
13. Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, Liao EY (2006) Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Mineral Res: Off J Am Soc Bone Mineral Res 21(10):1648–1656. doi:10.1359/jbmr.060707
14. Wang QP, Li XP, Wang M, Zhao LL, Li H, Xie H, Lu ZY (2014) Adiponectin exerts its negative effect on bone metabolism via OPG/RANKL pathway: an in vivo study. Endocrine 47(3):845–853. doi:10.1007/s12020-014-0216-z
15. Kohli SS, Kohli VS (2011) Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications. Indian J Endocrinol Metab 15(3):175–181. doi:10.4103/2230-8210.83401
16. Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290(6):E1253–E1261. doi:10.1152/ajpendo.00572.2004
17. de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56(6):1655–1661. doi:10.2337/db06-1506
18. Wang D, Jiang TJ, Liao L, Huang J (2013) Relationships between serum omentin-1 concentration and bone mineral density, and bone biochemical markers in Chinese women. Clin Chim Acta Int J Clin Chem 426:64–67. doi:10.1016/j.cca.2013.09.002
19. Tohidi M, Akbarzadeh S, Larijani B, Kalantarhormozi M, Ostovar A, Assadi M, Vahdat K, Farrokhnia M, Sanjdideh Z, Amirinejad R, Nabipour I (2012) Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women. Bone 51(5):876–881. doi:10.1016/j.bone.2012.08.117
20. Li XP, Zeng S, Wang M, Wu XP, Liao EY (2014) Relationships between serum omentin-1, body fat mass and bone mineral density in healthy Chinese male adults in Changsha area. J Endocrinol Invest 37(10):991–1000. doi:10.1007/s40618-014-0140-3
21. Zhang Y, Jiang Y, Tang S (2014) [Serum omentin-1 concentration and bone mineral density in postmenopausal women]. Zhong nan da xue xue bao Yi xue ban = Journal of Central South University Medical Sciences 39(4):389–394. doi:10.3969/j.issn.1672-7347.2014.04.012
22. Xie H, Xie PL, Luo XH, Wu XP, Zhou HD, Tang SY, Liao EY (2012) Omentin-1 exerts bone-sparing effect in ovariectomized mice. Osteoporos Int: J Establ Result Coop Between Eur Found Osteoporos Nat Osteoporos Found USA 23(4):1425–1436. doi:10.1007/s00198-011-1697-8
23. Boeing H, Wahrendorf J, Becker N (1999) EPIC-Germany-A source for studies into diet and risk of chronic diseases. European investigation into cancer and nutrition. Ann Nutr Metab 43(4):195–204
24. Langton CM, Palmer SB, Porter RW (1984) The measurement of broadband ultrasonic attenuation in cancellous bone. Eng Med 13(2):89–91
25. Kroke A, Klipstein-Grobusch K, Bergmann MM, Weber K, Boeing H (2000) Influence of body composition on quantitative ultrasound parameters of the os calcis in a population-based sample of pre- and postmenopausal women. Calcif Tissue Int 66(1):5–10
26. Jacobs S, Kroger J, Floegel A, Boeing H, Drogan D, Pischon T, Fritsche A, Prehn C, Adamski J, Isermann B, Weikert C, Schulze MB (2014) Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study. Am J Clin Nutr 100(3):891–900. doi:10.3945/ajcn.113.080317
27. Wittenbecher C, di Giuseppe R, Biemann R, Menzel J, Arregui M, Hoffmann J, Aleksandrova K, Boeing H, Isermann B, Schulze MB, Weikert C (2015) Reproducibility of retinol binding protein 4 and omentin-1 measurements over a four months period: a reliability study in a cohort of 207 apparently healthy participants. PLoS One 10(9):e0138480. doi:10.1371/journal.pone.0138480
28. Boeing H, Korfmann A, Bergmann MM (1999) Recruitment procedures of EPIC-Germany. European investigation into cancer and nutrition. Ann Nutr Metab 43(4):205–215
29. Wientzek A, Vigl M, Steindorf K, Bruhmann B, Bergmann MM, Harttig U, Katzke V, Kaaks R, Boeing H (2014) The improved physical activity index for measuring physical activity in EPIC Germany. PLoS One 9(3):e92005. doi:10.1371/journal.pone.0092005
30. Baron R, Kenny D (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173–1182
31. Fairchild AJ, MacKinnon DP (2009) A general model for testing mediation and moderation effects. Preven Sci: Off J Soc Prev Res 10(2):87–99. doi:10.1007/s11121-008-0109-6
32. Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 40(3):879–891
33. Hair JF, Hult GTM, Ringle CM, Sarstedt M (2014) Mediation analysis. In: A primer on partial least squares structural equation modeling (PLS-SEM). SAGE Publications, Inc., California, pp 219–225
34. Tenta R, Kontogianni MD, Yiannakouris N (2012) Association between circulating levels of adiponectin and indices of bone mass and bone metabolism in middle-aged post-menopausal women. J Endocrinol Invest 35(3):306–311. doi:10.3275/7744
35. Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN (2004) Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Mineral Res: Off J Am Soc Bone Mineral Res 19(4):546–551. doi:10.1359/JBMR.040107
36. Ozkurt B, Ozkurt ZN, Altay M, Aktekin CN, Caglayan O, Tabak Y (2009) The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery 20(2):78–84
37. Gonnelli S, Caffarelli C, Del Santo K, Cadirni A, Guerriero C, Lucani B, Franci B, Nuti R (2008) The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men. Calcif Tissue Int 83(1):55–60. doi:10.1007/s00223-008-9149-y
38. Kanaya N, Chen S (2010) Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice. Nutr Res 30(10):714–721. doi:10.1016/j.nutres.2010.09.001
39. Browner WS, Lui LY, Cummings SR (2001) Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J Clin Endocrinol Metab 86(2):631–637. doi:10.1210/jcem.86.2.7192
40. Kudlacek S, Schneider B, Woloszczuk W, Pietschmann P, Willvonseder R (2003) Serum levels of osteoprotegerin increase with age in a healthy adult population. Bone 32(6):681–686
41. Khosla S, Arrighi HM, Melton LJ 3rd, Atkinson EJ, O’Fallon WM, Dunstan C, Riggs BL (2002) Correlates of osteoprotegerin levels in women and men. Osteoporos Int: J Establ Result Coop Between Eur Found Osteoporos Nat Osteoporos Found USA 13(5):394–399
42. Rogers A, Saleh G, Hannon RA, Greenfield D, Eastell R (2002) Circulating estradiol and osteoprotegerin as determinants of bone turnover and bone density in postmenopausal women. J Clin Endocrinol Metab 87(10):4470–4475. doi:10.1210/jc.2002-020396
43. Hofbauer LC, Schoppet M (2004) Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292(4):490–495. doi:10.1001/jama.292.4.490
44. Lappa V, Dontas IA, Trovas G, Constantelou E, Galanos A, Lyritis GP (2007) Quantitative ultrasound is better correlated with bone mineral density and biochemical bone markers in elderly women. Clin Rheumatol 26(7):1067–1073. doi:10.1007/s10067-006-0448-2
45. Kaplan RC, Ho GY, Xue X, Rajpathak S, Cushman M, Rohan TE, Strickler HD, Scherer PE, Anastos K (2007) Within-individual stability of obesity-related biomarkers among women. Cancer Epidemiol Biomark Prev: Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 16(6):1291–1293. doi:10.1158/1055-9965.EPI-06-1089