Dietary methyl donor depletion suppresses intestinal adenoma development

Cancer Prevention Research

Volumn 9, Issue 10, 2016, Pages 812-820

  Hanley, Matthew P ^a   Kadaveru, Krishna ^b   Perret, Christine ^c   Giardina, Charles ^d   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUT COCHIN   (France)

^d UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CYANOCOBALAMIN; FOLIC ACID; METHIONINE;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RISK; CANCER STEM CELL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR VOLUME; ANIMAL; C57BL MOUSE; DEFICIENCY; DIET; INTESTINE TUMOR; METABOLISM; RANDOMIZATION; TRANSGENIC MOUSE;

ADENOMA; ANIMALS; CHOLINE; DIET; FOLIC ACID; INTESTINAL NEOPLASMS; METHIONINE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RANDOM ALLOCATION; VITAMIN B 12;

EID: 84991583841     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-16-0042     Document Type: Article

References (53)

1. Mason JB. Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons. Nutr Rev 2009;67:206-12.
2. Ulrich CM, Potter JD. Folate and cancer-timing is everything. JAMA 2007;297:2408-9.
3. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 2002;132:2350S-2355S.
4. Harnack L, Jacobs DR, Nicodemus K, Lazovich D, Anderson K, Folsom AR. Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer 2002;43:152-8.
5. Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: a meta-Analytical approach. Int J Cancer 2005;113: 825-8.
6. Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, et al. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-Analyses of data on 50,000 individuals. Lancet 2013;381:1029-36.
7. Ebbing M, Bønaa KH, Nygard O, Arnesen E, Ueland PM, Nordrehaug JE, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009;302:2119-26.
8. Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009;101:432-5.
9. Centers for Disease Control and Prevention (CDC). Spina bifida and anencephaly before and after folic acid mandate-United States, 1995-1996 and 1999-2000. MMWR Morb Mortal Wkly Rep 2004;53:362-5.
10. McDowell MA, Lacher DA, Pfeiffer CM, Mulinare J, Picciano MF, Rader JI, et al. Blood folate levels: the latest NHANES results. NCHS Data Brief 2008;1-8.
11. Cole BF, Baron JA, Sandler RS,Haile RW, AhnenDJ, Bresalier RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007;297:2351-9.
12. Kim G, Baik SH, Lee KY, Hur H, Min BS, Lyu CJ, et al. Colon carcinoma in childhood: review of the literature with four case reports. Int J Colorectal Dis 2013;28:157-64.
13. Boroff ES, Gurudu SR, Hentz JG, Leighton JA, Ramirez FC. Polyp and adenoma detection rates in the proximal and distal colon. Am J Gastroenterol 2013;108:993-9.
14. Drew DA, Goh G, Mo A, Grady JJ, Forouhar F, Egan G, et al. Colorectal polyp prevention by daily aspirin use is abrogated among active smokers. Cancer Causes Control 2015.
15. Hemmasi G, Sohrabi M, Zamani F, Ajdarkosh H, Rakhshani N, Khoonsari M, et al. Prevalence of colorectal adenoma in an average-risk population aged 40-50 versus 50-60 years. Eur J Cancer Prev 2015;24:386-90.
16. Choumenkovitch SF, Selhub J, Wilson PWF, Rader JI, Rosenberg IH, Jacques PF. Folic acid intake from fortification in United States exceeds predictions. J Nutr 2002;132:2792-8.
17. Wagner C. Biochemical role of folate in cellular metabolism. Folate Health Dis. Second Edition. New York: Marcel Dekker;1995. p.23-42.
18. Kräutler B. Vitamin B12: chemistry and biochemistry. Biochem Soc Trans 2005;33:806-10.
19. Kelemen LE. The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? Int J Cancer 2006;119:243-50.
20. Bulgar AD, Weeks LD, Miao Y, Yang S, Xu Y, Guo C, et al. Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell Death Dis 2012;3:e252.
21. Moser AR, Luongo C, Gould KA, McNeley MK, Shoemaker AR, Dove WF. ApcMin: a mouse model for intestinal andmammary tumorigenesis. Eur J Cancer 1995;31A:1061-4.
22. Kadaveru K, Protiva P, Greenspan EJ, Kim Y-I, Rosenberg DW. Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc (Min/+) mice. Cancer Prev Res 2012;5:911-20.
23. Colnot S, Niwa-Kawakita M, Hamard G, Godard C, Le Plenier S, Houbron C, et al. Colorectal cancers in a newmouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest 2004;84:1619-30.
24. Nakanishi M, Montrose DC, Clark P, Nambiar PR, Belinsky GS, Claffey KP, et al. Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. Cancer Res 2008;68:3251-9.
25. Janakiram NB, Rao CV. Molecular markers and targets for colorectal cancer prevention. Acta Pharmacol Sin 2008;29:1-20.
26. St Clair WH, Osborne JW. Crypt fission and crypt number in the small and large bowel of postnatal rats. Cell Tissue Kinet 1985;18:255-62.
27. Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis 2014;35:237-46.
28. Berlanga-Acosta J, Playford RJ,MandirN, Goodlad RA. Gastrointestinal cell proliferation and crypt fission are separate but complementary means of increasing tissue mass following infusion of epidermal growth factor in rats. Gut 2001;48:803-7.
29. Takahashi H, Hosono K, Endo H, Nakajima A. Colon epithelial proliferation and carcinogenesis in diet-induced obesity. J Gastroenterol Hepatol 2013;28 Suppl 4:41-7.
30. Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, et al. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 2013;45:98-103.
31. Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, et al. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest 2014;124:1283-95.
32. Buchman AL,DubinMD, Moukarzel AA, Jenden DJ, Roch M, Rice KM, et al. Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology 1995;22:1399-403.
33. Courtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol 2004;173:3186-92.
34. Keith MO, Tryphonas L. Choline deficiency and the reversibility of renal lesions in rats. J Nutr 1978;108:434-46.
35. Brunt EM.Pathology of fatty liver disease. Mod Pathol 2007;20:S40-8.
36. Kim Y-I. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 2007;51:267-92.
37. Ericson U, Sonestedt E, Gullberg B, Olsson H, Wirfält E. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort. Am J Clin Nutr 2007;86:434-43.
38. Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI. Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/-mice. Cancer Res 2000;60:3191-9.
39. Fischer JM, Miller AJ, Shibata D, Liskay RM. Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene 2012;31: 2028-38.
40. Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res 1988;48:235-45.
41. Lasko CM, Bird RP. Modulation of aberrant crypt foci by dietary fat and caloric restriction: the effects of delayed intervention. Cancer Epidemiol Biomark Prev 1995;4:49-55.
42. Mills SJ, Mathers JC, Chapman PD, Burn J, Gunn A. Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis. Gut 2001;48:41-6.
43. Tammariello AE, Milner JA. Mouse models for unraveling the importance of diet in colon cancer prevention. J Nutr Biochem 2010;21:77-88.
44. Lin CC, Lu YP, Lou YR, Ho CT, Newmark HH, MacDonald C, et al. Inhibition by dietary dibenzoylmethane of mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice. Cancer Lett 2001;168: 125-32.
45. Barone M, Notarnicola M, Caruso MG, Scavo MP, Viggiani MT, Tutino V, et al. Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in ApcMin/+ mice. Carcinogenesis 2014;35:1613-9.
46. Kim Y-I. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999;10:66-88.
47. Crott JW, Liu Z, Keyes MK, Choi S-W, Jang H, Moyer MP, et al. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. J Nutr Biochem 2008;19:328-35.
48. Yu D-H, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, et al. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol 2015;16:211.
49. Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, et al. Influence of threonine metabolism on S-Adenosylmethionine and histone methylation. Science 2013;339:222-6.
50. Giannakis M, Stappenbeck TS, Mills JC, Leip DG, Lovett M, Clifton SW, et al. Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem 2006;281:11292-300.
51. Kwatra D, Subramaniam D, Ramamoorthy P, Standing D, Moran E, Velayutham R, et al. Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy. Evid-Based Complement Altern Med 2013;2013:702869.
52. Kim Y-I. Role of folate in colon cancer development and progression. J Nutr 2003;133:3731S-9S.
53. Wu X, Lippman SM. An intermittent approach for cancer chemoprevention. Nat Rev Cancer 2011;11:879-85.