Paternal age explains a major portion of De novo germline mutation rate variability in healthy individuals

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Girard, Simon L ^a,b   Bourassa, Cynthia V ^b   Perreault, Louis Philippe Lemieux ^c,d   Legault, Marc André ^c,d   Barhdadi, Amina ^c,d   Ambalavanan, Amirthagowri ^b   Brendgen, Mara ^e   Vitaro, Frank ^d   Noreau, Anne ^b   Dionne, Ginette ^f   Tremblay, Richard E ^d,g   Dion, Patrick A ^b   Boivin, Michel ^f   Dubé, Marie Pierre ^c,d   Rouleau, Guy A ^b  

^a UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MONTREAL HEART INSTITUTE   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^f UNIVERSITÉ LAVAL   (Canada)

^g UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DE NOVO MUTATION; FAMILY STUDY; GENETIC CORRELATION; GENETIC VARIABILITY; GERMLINE MUTATION; HUMAN; INDEL MUTATION; MALE; MUTATION RATE; PATERNAL AGE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMISTRY; DNA SEQUENCE; FEMALE; GENOTYPE; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; YOUNG ADULT;

DNA;

ADULT; DNA; DNA COPY NUMBER VARIATIONS; FEMALE; GENOTYPE; GERM-LINE MUTATION; HUMANS; MALE; MIDDLE AGED; PATERNAL AGE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

EID: 84991494495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0164212     Document Type: Article

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