메뉴 건너뛰기




Volumn 51, Issue 11, 2016, Pages 1812-1817

Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients

Author keywords

BRAF; Early onset colorectal cancer; MSI

Indexed keywords

B RAF KINASE; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; TUMOR MARKER; DNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84991383859     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2016.07.015     Document Type: Article
Times cited : (75)

References (50)
  • 1
    • 84860120363 scopus 로고    scopus 로고
    • Surveillance, epidemiology, and end results program database
    • [Accessed June 30, 2015]
    • [1] Surveillance, epidemiology, and end results program database. http://seer.cancer.gov/ [Accessed June 30, 2015].
  • 2
    • 0026667355 scopus 로고
    • Prognostic factors and outcome in patients 21 years and under with colorectal carcinoma
    • [discussion 1089-90]
    • [2] LaQuaglia, MP, Heller, G, Filippa, DA, et al. Prognostic factors and outcome in patients 21 years and under with colorectal carcinoma. J Pediatr Surg 27:8 (1992), 1085–1089 [discussion 1089-90].
    • (1992) J Pediatr Surg , vol.27 , Issue.8 , pp. 1085-1089
    • LaQuaglia, M.P.1    Heller, G.2    Filippa, D.A.3
  • 3
    • 0035157748 scopus 로고    scopus 로고
    • Colorectal carcinoma in children and adolescents—a report of seven cases
    • [3] Vastyan, AM, Walker, J, Pinter, AB, et al. Colorectal carcinoma in children and adolescents—a report of seven cases. Eur J Pediatr Surg 11:5 (2001), 338–341.
    • (2001) Eur J Pediatr Surg , vol.11 , Issue.5 , pp. 338-341
    • Vastyan, A.M.1    Walker, J.2    Pinter, A.B.3
  • 4
    • 0036480856 scopus 로고    scopus 로고
    • Colorectal carcinoma in nepalese young adults: presentation and outcome
    • [4] Singh, Y, Vaidya, P, Hemandas, AK, et al. Colorectal carcinoma in nepalese young adults: presentation and outcome. Gan To Kagaku Ryoho 29:Suppl. 1 (2002), 223–229.
    • (2002) Gan To Kagaku Ryoho , vol.29 , pp. 223-229
    • Singh, Y.1    Vaidya, P.2    Hemandas, A.K.3
  • 5
    • 37649021203 scopus 로고    scopus 로고
    • Colorectal carcinoma in childhood and adolescence: a clinicopathologic review
    • [5] Hill, DA, Furman, WL, Billups, CA, et al. Colorectal carcinoma in childhood and adolescence: a clinicopathologic review. J Clin Oncol 25:36 (2007), 5808–5814.
    • (2007) J Clin Oncol , vol.25 , Issue.36 , pp. 5808-5814
    • Hill, D.A.1    Furman, W.L.2    Billups, C.A.3
  • 6
    • 2442687802 scopus 로고    scopus 로고
    • Colorectal cancer in the young: a 12-year review of patients 30 years or less
    • [6] Kam, MH, Eu, KW, Barben, CP, et al. Colorectal cancer in the young: a 12-year review of patients 30 years or less. Colorectal Dis 6:3 (2004), 191–194.
    • (2004) Colorectal Dis , vol.6 , Issue.3 , pp. 191-194
    • Kam, M.H.1    Eu, K.W.2    Barben, C.P.3
  • 8
    • 0141480984 scopus 로고    scopus 로고
    • Colorectal cancer in young patients under 40 years of age. Comparison with old patients in a well defined jordanian population
    • [8] Al-Jaberi, TM, Yaghan, RJ, El-Heis, HA, Colorectal cancer in young patients under 40 years of age. Comparison with old patients in a well defined jordanian population. Saudi Med J 24:8 (2003), 871–874.
    • (2003) Saudi Med J , vol.24 , Issue.8 , pp. 871-874
    • Al-Jaberi, T.M.1    Yaghan, R.J.2    El-Heis, H.A.3
  • 9
    • 76249128517 scopus 로고    scopus 로고
    • Distinct features of colorectal cancer in children and adolescents
    • [9] Sultan, I, Rodriguez-Galindo, C, El-Taani, H, et al. Distinct features of colorectal cancer in children and adolescents. Cancer 116:3 (2010), 758–765.
    • (2010) Cancer , vol.116 , Issue.3 , pp. 758-765
    • Sultan, I.1    Rodriguez-Galindo, C.2    El-Taani, H.3
  • 10
    • 0023750476 scopus 로고
    • Carcinoma of the colon in children: report of a case and review of the literature
    • [10] Takai, S, Yamamura, M, Sakaguchi, M, et al. Carcinoma of the colon in children: report of a case and review of the literature. Jpn J Surg 18:3 (1988), 341–345.
    • (1988) Jpn J Surg , vol.18 , Issue.3 , pp. 341-345
    • Takai, S.1    Yamamura, M.2    Sakaguchi, M.3
  • 11
    • 10744233436 scopus 로고    scopus 로고
    • Clinical and pathological prognostic indicators with colorectal mucinous carcinomas
    • [11] Kubota, K, Akasu, T, Fujita, S, et al. Clinical and pathological prognostic indicators with colorectal mucinous carcinomas. Hepatogastroenterology 51:55 (2004), 142–146.
    • (2004) Hepatogastroenterology , vol.51 , Issue.55 , pp. 142-146
    • Kubota, K.1    Akasu, T.2    Fujita, S.3
  • 12
    • 0026101327 scopus 로고
    • Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis
    • [12] Dunlop, MG, Wyllie, AH, Steel, CM, et al. Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis. Lancet 337:8737 (1991), 313–316.
    • (1991) Lancet , vol.337 , Issue.8737 , pp. 313-316
    • Dunlop, M.G.1    Wyllie, A.H.2    Steel, C.M.3
  • 13
    • 0032231445 scopus 로고    scopus 로고
    • Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls
    • [13] Farrington, SM, Lin-Goerke, J, Ling, J, et al. Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls. Am J Hum Genet 63:3 (1998), 749–759.
    • (1998) Am J Hum Genet , vol.63 , Issue.3 , pp. 749-759
    • Farrington, S.M.1    Lin-Goerke, J.2    Ling, J.3
  • 14
    • 0034642606 scopus 로고    scopus 로고
    • Genetic and phenotypic correlates of colorectal cancer in young patients
    • [14] Datta, RV, LaQuaglia, MP, Paty, PB, Genetic and phenotypic correlates of colorectal cancer in young patients. N Engl J Med 342:2 (2000), 137–138.
    • (2000) N Engl J Med , vol.342 , Issue.2 , pp. 137-138
    • Datta, R.V.1    LaQuaglia, M.P.2    Paty, P.B.3
  • 15
    • 0142232032 scopus 로고    scopus 로고
    • Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    • [15] Shia, J, Ellis, NA, Paty, PB, et al. Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer. Am J Surg Pathol 27:11 (2003), 1407–1417.
    • (2003) Am J Surg Pathol , vol.27 , Issue.11 , pp. 1407-1417
    • Shia, J.1    Ellis, N.A.2    Paty, P.B.3
  • 16
    • 21644484236 scopus 로고    scopus 로고
    • DNA extraction and quantitation of forensic samples using the phenol–chloroform method and real-time PCR
    • [16] Kochl, S, Niederstatter, H, Parson, W, DNA extraction and quantitation of forensic samples using the phenol–chloroform method and real-time PCR. Methods Mol Biol 297 (2005), 13–30.
    • (2005) Methods Mol Biol , vol.297 , pp. 13-30
    • Kochl, S.1    Niederstatter, H.2    Parson, W.3
  • 17
    • 0041411494 scopus 로고    scopus 로고
    • Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer
    • [17] Nash, GM, Gimbel, M, Shia, J, et al. Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer. J Clin Oncol 21:16 (2003), 3105–3112.
    • (2003) J Clin Oncol , vol.21 , Issue.16 , pp. 3105-3112
    • Nash, G.M.1    Gimbel, M.2    Shia, J.3
  • 18
    • 0033531235 scopus 로고    scopus 로고
    • Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors
    • [18] Khanna, M, Park, P, Zirvi, M, et al. Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors. Oncogene 18:1 (1999), 27–38.
    • (1999) Oncogene , vol.18 , Issue.1 , pp. 27-38
    • Khanna, M.1    Park, P.2    Zirvi, M.3
  • 19
    • 17444424227 scopus 로고    scopus 로고
    • Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction
    • [19] Turner, DJ, Zirvi, MA, Barany, F, et al. Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction. J Cutan Pathol 32:5 (2005), 334–339.
    • (2005) J Cutan Pathol , vol.32 , Issue.5 , pp. 334-339
    • Turner, D.J.1    Zirvi, M.A.2    Barany, F.3
  • 20
    • 11144279281 scopus 로고    scopus 로고
    • Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms
    • [20] Shia, J, Klimstra, DS, Nafa, K, et al. Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. Am J Surg Pathol 29:1 (2005), 96–104.
    • (2005) Am J Surg Pathol , vol.29 , Issue.1 , pp. 96-104
    • Shia, J.1    Klimstra, D.S.2    Nafa, K.3
  • 21
    • 0037364659 scopus 로고    scopus 로고
    • Genetic tumor markers with prognostic impact in Dukes’ stages B and C colorectal cancer patients
    • [21] Diep, CB, Thorstensen, L, Meling, GI, et al. Genetic tumor markers with prognostic impact in Dukes’ stages B and C colorectal cancer patients. J Clin Oncol 21:5 (2003), 820–829.
    • (2003) J Clin Oncol , vol.21 , Issue.5 , pp. 820-829
    • Diep, C.B.1    Thorstensen, L.2    Meling, G.I.3
  • 22
    • 0031891134 scopus 로고    scopus 로고
    • Prognostic significance of DNA replication errors in young patients with colorectal cancer
    • [22] Lukish, JR, Muro, K, DeNobile, J, et al. Prognostic significance of DNA replication errors in young patients with colorectal cancer. Ann Surg 227:1 (1998), 51–56.
    • (1998) Ann Surg , vol.227 , Issue.1 , pp. 51-56
    • Lukish, J.R.1    Muro, K.2    DeNobile, J.3
  • 23
    • 0029089259 scopus 로고
    • Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives
    • [23] Marra, G, Boland, CR, Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst 87:15 (1995), 1114–1125.
    • (1995) J Natl Cancer Inst , vol.87 , Issue.15 , pp. 1114-1125
    • Marra, G.1    Boland, C.R.2
  • 24
    • 46449087103 scopus 로고    scopus 로고
    • Pathology of the hereditary colorectal carcinoma
    • [24] Gatalica, Z, Torlakovic, E, Pathology of the hereditary colorectal carcinoma. Fam Cancer 7:1 (2008), 15–26.
    • (2008) Fam Cancer , vol.7 , Issue.1 , pp. 15-26
    • Gatalica, Z.1    Torlakovic, E.2
  • 25
    • 47949122502 scopus 로고    scopus 로고
    • Hereditary colorectal cancer syndromes: familial adenomatous polyposis and Lynch syndrome
    • [25] Al-Sukhni, W, Aronson, M, Gallinger, S, Hereditary colorectal cancer syndromes: familial adenomatous polyposis and Lynch syndrome. Surg Clin North Am 88:4 (2008), 819–844.
    • (2008) Surg Clin North Am , vol.88 , Issue.4 , pp. 819-844
    • Al-Sukhni, W.1    Aronson, M.2    Gallinger, S.3
  • 26
    • 46449092873 scopus 로고    scopus 로고
    • Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management
    • [26] Lynch, HT, Lynch, JF, Lynch, PM, et al. Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management. Fam Cancer 7:1 (2008), 27–39.
    • (2008) Fam Cancer , vol.7 , Issue.1 , pp. 27-39
    • Lynch, H.T.1    Lynch, J.F.2    Lynch, P.M.3
  • 27
    • 0034585282 scopus 로고    scopus 로고
    • Familial colorectal cancer: pathology and molecular characteristics
    • [27] Jass, JR, Familial colorectal cancer: pathology and molecular characteristics. Lancet Oncol 1 (2000), 220–226.
    • (2000) Lancet Oncol , vol.1 , pp. 220-226
    • Jass, J.R.1
  • 28
    • 58749110893 scopus 로고    scopus 로고
    • Molecular screening of all colorectal tumors diagnosed before age 50 years followed by genetic testing efficiently identifies Lynch syndrome cases
    • [28] Jenkins, MA, Dowty, JG, Hopper, JL, et al. Molecular screening of all colorectal tumors diagnosed before age 50 years followed by genetic testing efficiently identifies Lynch syndrome cases. Int J Cancer, 124(5), 2009.
    • (2009) Int J Cancer , vol.124 , Issue.5
    • Jenkins, M.A.1    Dowty, J.G.2    Hopper, J.L.3
  • 29
    • 58749091265 scopus 로고    scopus 로고
    • Role for genetic anticipation in Lynch syndrome
    • [29] Nilbert, M, Timshel, S, Bernstein, I, et al. Role for genetic anticipation in Lynch syndrome. J Clin Oncol 27:3 (2009), 360–364.
    • (2009) J Clin Oncol , vol.27 , Issue.3 , pp. 360-364
    • Nilbert, M.1    Timshel, S.2    Bernstein, I.3
  • 30
    • 33846986366 scopus 로고    scopus 로고
    • Colorectal cancer in the young patient
    • [30] Leff, DR, Chen, A, Roberts, D, et al. Colorectal cancer in the young patient. Am Surg 73:1 (2007), 42–47.
    • (2007) Am Surg , vol.73 , Issue.1 , pp. 42-47
    • Leff, D.R.1    Chen, A.2    Roberts, D.3
  • 31
    • 0036103113 scopus 로고    scopus 로고
    • Genetic and clinical characterisation of familial adenomatous polyposis: a population based study
    • [31] Moisio, AL, Jarvinen, H, Peltomaki, P, Genetic and clinical characterisation of familial adenomatous polyposis: a population based study. Gut 50:6 (2002), 845–850.
    • (2002) Gut , vol.50 , Issue.6 , pp. 845-850
    • Moisio, A.L.1    Jarvinen, H.2    Peltomaki, P.3
  • 32
    • 55849140517 scopus 로고    scopus 로고
    • Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    • [32] Poynter, JN, Siegmund, KD, Weisenberger, DJ, et al. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev 17:11 (2008), 3208–3215.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.11 , pp. 3208-3215
    • Poynter, J.N.1    Siegmund, K.D.2    Weisenberger, D.J.3
  • 33
    • 34250639863 scopus 로고    scopus 로고
    • Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR
    • [33] Bettstetter, M, Dechant, S, Ruemmele, P, et al. Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin Cancer Res 13:11 (2007), 3221–3228.
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3221-3228
    • Bettstetter, M.1    Dechant, S.2    Ruemmele, P.3
  • 34
    • 35148875104 scopus 로고    scopus 로고
    • Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer
    • [34] Hitchins, MP, Lin, VA, Buckle, A, et al. Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res 67:19 (2007), 9107–9116.
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9107-9116
    • Hitchins, M.P.1    Lin, V.A.2    Buckle, A.3
  • 35
    • 23844487761 scopus 로고    scopus 로고
    • BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors
    • [35] Lubomierski, N, Plotz, G, Wormek, M, et al. BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors. Cancer 104:5 (2005), 952–961.
    • (2005) Cancer , vol.104 , Issue.5 , pp. 952-961
    • Lubomierski, N.1    Plotz, G.2    Wormek, M.3
  • 36
    • 1642535480 scopus 로고    scopus 로고
    • BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
    • [36] Deng, G, Bell, I, Crawley, S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res 10:1 Pt 1 (2004), 191–195.
    • (2004) Clin Cancer Res , vol.10 , Issue.1 , pp. 191-195
    • Deng, G.1    Bell, I.2    Crawley, S.3
  • 37
    • 34547405167 scopus 로고    scopus 로고
    • Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer
    • [37] Loughrey, MB, Waring, PM, Tan, A, et al. Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer. Fam Cancer 6:3 (2007), 301–310.
    • (2007) Fam Cancer , vol.6 , Issue.3 , pp. 301-310
    • Loughrey, M.B.1    Waring, P.M.2    Tan, A.3
  • 38
    • 0025047375 scopus 로고
    • Survival in patients with large-bowel cancer. A population-based investigation from the Melbourne colorectal cancer study
    • [38] Kune, GA, Kune, S, Field, B, et al. Survival in patients with large-bowel cancer. A population-based investigation from the Melbourne colorectal cancer study. Dis Colon Rectum 33:11 (1990), 938–946.
    • (1990) Dis Colon Rectum , vol.33 , Issue.11 , pp. 938-946
    • Kune, G.A.1    Kune, S.2    Field, B.3
  • 39
    • 0026209479 scopus 로고
    • Young patients with colorectal cancer: the University of Mississippi medical center experience 1970–1990
    • [39] Raymond, PL, Skelton, DS, Hsu, HS, Young patients with colorectal cancer: the University of Mississippi medical center experience 1970–1990. J Miss State Med Assoc 32:8 (1991), 298–304.
    • (1991) J Miss State Med Assoc , vol.32 , Issue.8 , pp. 298-304
    • Raymond, P.L.1    Skelton, D.S.2    Hsu, H.S.3
  • 40
    • 34250201891 scopus 로고    scopus 로고
    • Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer
    • [40] Maestro, ML, Vidaurreta, M, Sanz-Casla, MT, et al. Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. Ann Surg Oncol 14:3 (2007), 1229–1236.
    • (2007) Ann Surg Oncol , vol.14 , Issue.3 , pp. 1229-1236
    • Maestro, M.L.1    Vidaurreta, M.2    Sanz-Casla, M.T.3
  • 41
    • 22244472992 scopus 로고    scopus 로고
    • Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    • [41] Samowitz, WS, Sweeney, C, Herrick, J, et al. Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 65:14 (2005), 6063–6069.
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6063-6069
    • Samowitz, W.S.1    Sweeney, C.2    Herrick, J.3
  • 42
    • 54249165951 scopus 로고    scopus 로고
    • Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases
    • [42] Barault, L, Charon-Barra, C, Jooste, V, et al. Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. Cancer Res 68:20 (2008), 8541–8546.
    • (2008) Cancer Res , vol.68 , Issue.20 , pp. 8541-8546
    • Barault, L.1    Charon-Barra, C.2    Jooste, V.3
  • 43
    • 71449128212 scopus 로고    scopus 로고
    • Colon carcinoma in children and adolescents: prognostic factors and outcome—review of 11 cases
    • [43] Salas-Valverde, S, Lizano, A, Gamboa, Y, et al. Colon carcinoma in children and adolescents: prognostic factors and outcome—review of 11 cases. Pediatr Surg Int 25 (2009), 1073–1076.
    • (2009) Pediatr Surg Int , vol.25 , pp. 1073-1076
    • Salas-Valverde, S.1    Lizano, A.2    Gamboa, Y.3
  • 44
    • 38549132356 scopus 로고    scopus 로고
    • Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy
    • [44] Ferrari, A, Rognone, A, Casanova, M, et al. Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy. Pediatr Blood Cancer 50 (2008), 588–593.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 588-593
    • Ferrari, A.1    Rognone, A.2    Casanova, M.3
  • 45
    • 84893653548 scopus 로고    scopus 로고
    • ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis)
    • [45] Hegde, M, Ferber, M, Mao, R, et al. ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genet Med 16:1 (2014), 101–116.
    • (2014) Genet Med , vol.16 , Issue.1 , pp. 101-116
    • Hegde, M.1    Ferber, M.2    Mao, R.3
  • 46
    • 84880918800 scopus 로고    scopus 로고
    • The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome
    • [46] Martin-Lopez, JV, Fischel, R, The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome. Fam Cancer 12:2 (2013), 159–168.
    • (2013) Fam Cancer , vol.12 , Issue.2 , pp. 159-168
    • Martin-Lopez, J.V.1    Fischel, R.2
  • 47
    • 84883856165 scopus 로고    scopus 로고
    • Colorectal cancer in patients under 50 years of age: a retrospective analysis of two institutions’ experience
    • [47] Myers, EA, Feingold, DL, Forde, KA, et al. Colorectal cancer in patients under 50 years of age: a retrospective analysis of two institutions’ experience. World J Gastroenterol 19:34 (2013), 5651–5657.
    • (2013) World J Gastroenterol , vol.19 , Issue.34 , pp. 5651-5657
    • Myers, E.A.1    Feingold, D.L.2    Forde, K.A.3
  • 48
    • 84902330508 scopus 로고    scopus 로고
    • New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis
    • [48] Valle, L, Hernandez-Illan, E, Bellido, F, et al. New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. Hum Mol Genet 23:13 (2014), 3506–3512.
    • (2014) Hum Mol Genet , vol.23 , Issue.13 , pp. 3506-3512
    • Valle, L.1    Hernandez-Illan, E.2    Bellido, F.3
  • 49
    • 34249785078 scopus 로고    scopus 로고
    • Role of BRAF–V600E in the serrated pathway of colorectal tumourigenesis
    • [49] Minoo, P, Moyer, MP, Jass, JR, Role of BRAF–V600E in the serrated pathway of colorectal tumourigenesis. J Pathol 212 (2007), 124–133.
    • (2007) J Pathol , vol.212 , pp. 124-133
    • Minoo, P.1    Moyer, M.P.2    Jass, J.R.3
  • 50
    • 84881640407 scopus 로고    scopus 로고
    • Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication
    • [50] Lochhead, P, Kuchiba, A, Imamura, Y, et al. Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J Natl Cancer Inst 105 (2013), 1151–1156.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1151-1156
    • Lochhead, P.1    Kuchiba, A.2    Imamura, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.