Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis?

Spine

Volumn 37, Issue 9, 2012, Pages

  Dhawale, Arjun A ^a   Shah, Suken A ^a   Sponseller, Paul D ^b   Bastrom, Tracey ^c   Neiss, Geraldine ^a   Yorgova, Petya ^a   Newton, Peter O ^c   Yaszay, Burt ^c   Abel, Mark F ^d   Shufflebarger, Harry ^e   Gabos, Peter G ^a   Dabney, Kirk W ^a   Miller, Freeman ^a  

^a NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e MIAMI CHILDREN'S HOSPITAL   (United States)

Author keywords

antifi brinolytics; blood loss; cerebral palsy; EACA; Scoliosis; TXA

Indexed keywords

AMINOCAPROIC ACID; TRANEXAMIC ACID;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; BLOOD TRANSFUSION; CEREBRAL PALSY; CHILD; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HOSPITALIZATION; HUMAN; LENGTH OF STAY; MALE; PEDIATRIC SURGERY; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; SCOLIOSIS; SPINE FUSION; TREATMENT OUTCOME;

6-AMINOCAPROIC ACID; ADOLESCENT; ANALYSIS OF VARIANCE; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; BLOOD TRANSFUSION, AUTOLOGOUS; CEREBRAL PALSY; CHILD; DATABASES, FACTUAL; HUMANS; LENGTH OF STAY; OPERATIVE BLOOD SALVAGE; RETROSPECTIVE STUDIES; SCOLIOSIS; SPINAL FUSION; TIME FACTORS; TRANEXAMIC ACID; TREATMENT OUTCOME; UNITED STATES;

EID: 84860342335     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31823d009b     Document Type: Review

References (19)

1. Meert KL, Kannan S, Mooney JF. Predictors of red cell transfusion in children and adolescents undergoing spinal fusion surgery. Spine (Phila Pa 1976) 2002;27:2137-42.
2. Kannan S, Meert KL, Mooney JF, et al. Bleeding and coagulation changes during spinal fusion surgery: a comparison of neuromus-cular and idiopathic scoliosis patients. Pediatr Crit Care Med 2002;3:364-9.
3. Brenn BR, Theroux MC, Dabney KW, et al. Clotting parameters and thromboelastography in children with neuromuscular and idio-pathic scoliosis undergoing posterior spinal fusion. Spine (Phila Pa 1976) 2004;29:E310-4.
4. Elgafy H, Bransford RJ, McGuire RA, et al. Blood loss in major spine surgery: are there effective measures to decrease massive hemorrhage in major spine fusion surgery? Spine (Phila Pa 1976) 2010;35:S47-56.
5. Murray DJ, Pennell BJ, Weinstein SL, et al. Packed red cells in acute blood loss: dilutional coagulopathy as a cause of surgical bleeding. Anesth Analg 1995;80:336-42.
6. Winter SL, Kriel RL, Novacheck TF, et al. Perioperative blood loss: the effect of valproate. Pediatr Neurol 1996;15:19-22. (Pubitemid 26268808)
7. Gill JB, Chin Y, Levin A, et al. The use of antifibrinolytic agents in spine surgery. A meta-analysis. J Bone Joint Surg Am 2008;90:2399-407.
8. Thompson GH, Florentino-Pineda I, Poe-Kochert C. The role of amicar in decreasing perioperative blood loss in idiopathic scoliosis. Spine (Phila Pa 1976) 2005;30:S94-9. (Pubitemid 41292210)
9. Sethna NF, Zurakowski D, Brustowicz RM, et al. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology 2005;102:727-32. (Pubitemid 40462851)
10. Tzortzopoulou A, Cepeda MS, Schumann R, et al. Antifibrinol-ytic agents for reducing blood loss in scoliosis surgery in children. Cochrane Database Syst Rev 2008;(3): CD006883.
11. Thompson GH, Florentino-Pineda I, Poe-Kochert C, et al. Role of amicar in surgery for neuromuscular scoliosis. Spine (Phila Pa 1976) 2008;33:2623-9.
12. Kasimian S, Skaggs DL, Sankar WN, et al. Aprotinin in pedi-atric neuromuscular scoliosis surgery. Eur Spine J 2008;17:1671-5.
13. Shapiro F, Zurakowski D, Sethna NF. Tranexamic acid dimin-ishes intraoperative blood loss and transfusion in spinal fusions for Duchenne muscular dystrophy scoliosis. Spine (Phila Pa 1976) 2007;32:2278-83. (Pubitemid 47415113)
14. Carless PA, Henry DA, Moxey AJ, et al. Cell salvage for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2010;(4): CD001888.
15. Carless PA, Henry DA, Moxey AJ, et al. Desmopressin for minimis-ing perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2004;(1): CD001884.
16. Florentino-Pineda I, Thompson GH, Poe-Kochert C, et al. The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine (Phila Pa 1976) 2004;29:233-8. (Pubitemid 38155721)
17. Neilipovitz DT, Murto K, Hall L, et al. A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg 2001;93:82-7. (Pubitemid 32601158)
18. Keverline JP, Sanders JO. Hematuria associated with low-volume cell saver in pediatric orthopaedics. J Pediatr Orthop 1998;18:594-7. (Pubitemid 28446807)
19. Vorweg M, Muckel G, Knüttgen D, et al. [Heparin-induced coagu-lation disturbance from mechanical autotransfusion]. Anaesthesist 1998;47:979-81. (Pubitemid 29021501)