Ozone inhalation provokes glucocorticoid-dependent and -independent effects on inflammatory and metabolic pathways

Toxicological Sciences

Volumn 152, Issue 1, 2016, Pages 17-28

  Thomson, Errol M ^a   Pal, Shinjini ^a   Guénette, Josée ^a   Wade, Michael G ^a   Atlas, Ella ^a   Holloway, Alison C ^b   Williams, Andrew ^a   Vincent, Renaud ^a  

^a HEALTH CANADA   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Air pollution; Glucocorticoid; Hypothalamic pituitary adrenal (HPA) axis; Inflammation; Metabolic effects; Ozone; Stress response; Systemic effects

Indexed keywords

CHEMOKINE; CORTICOSTERONE; CYTOKINE; EPINEPHRINE; GHRELIN; GLUCAGON; GLUCOCORTICOID; INSULIN; METYRAPONE; OZONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; AUTACOID; BIOLOGICAL MARKER; ENZYME INHIBITOR; PYRIDINE DERIVATIVE; STEROID 11BETA MONOOXYGENASE;

AIR POLLUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE EXPRESSION; HEART; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE DEFICIENCY; INFLAMMATION; INHALATION; KIDNEY; LIVER; LUNG; MALE; METABOLISM; MOLECULAR BIOLOGY; NONHUMAN; PLASMA; RAT; SIGNAL TRANSDUCTION; SPLEEN; ADRENAL GLAND; AIR POLLUTANT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; ENERGY METABOLISM; EXPOSURE; FISCHER 344 RAT; PNEUMONIA; TOXICITY; UPREGULATION;

ADRENAL GLANDS; AIR POLLUTANTS; ANIMALS; BIOMARKERS; CORTICOSTERONE; CYTOKINES; ENERGY METABOLISM; ENZYME INHIBITORS; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; MALE; OZONE; PNEUMONIA; PYRIDINES; RATS, INBRED F344; STEROID 11-BETA-HYDROXYLASE; UP-REGULATION;

EID: 84991290288     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw061     Document Type: Article

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