Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins

Diabetologia

Volumn 60, Issue 1, 2017, Pages 169-181

  Heinonen, Sini ^a   Muniandy, Maheswary ^a   Buzkova, Jana ^a   Mardinoglu, Adil ^b,c   Rodríguez, Amaia ^d,e   Frühbeck, Gema ^d,e   Hakkarainen, Antti ^f   Lundbom, Jesper ^f,g   Lundbom, Nina ^f   Kaprio, Jaakko ^a,h   Rissanen, Aila ^a,f   Pietiläinen, Kirsi H ^a,f  

^a UNIVERSITY OF HELSINKI   (Finland)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^d UNIVERSITY CLINIC OF NAVARRA   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^g HEINRICH HEINE UNIVERSITY   (Germany)

^h NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Adipocytes; Gene expression; Mitochondria; Obesity; Twins

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; 1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE 9; ADIPONECTIN; C REACTIVE PROTEIN; CALSEQUESTRIN; CALSEQUESTRIN 2; CARBONATE DEHYDRATASE III; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD163 ANTIGEN; CHOLESTEROL; CREATINE KINASE BB; CYCLOOXYGENASE 1; EPIREGULIN; FC RECEPTOR IIB; G PROTEIN COUPLED RECEPTOR 183; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MITOCHONDRIAL DNA; MONOCYTE CHEMOTACTIC PROTEIN 4; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA 12S; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ADIPOSE TISSUE; ADULT; AMINO ACID METABOLISM; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CELL ISOLATION; CHOLESTEROL BLOOD LEVEL; CITRIC ACID CYCLE; COHORT ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; FAT CONTENT; FATTY ACID OXIDATION; FEMALE; FINN (CITIZEN); GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; MONOZYGOTIC TWINS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; TRIACYLGLYCEROL BLOOD LEVEL; TWIN DISCORDANCE; WESTERN BLOTTING; ABDOMINAL FAT; GENETICS; METABOLISM; YOUNG ADULT;

ABDOMINAL FAT; ADIPOCYTES; ADIPOSE TISSUE; ADULT; C-REACTIVE PROTEIN; FEMALE; HUMANS; MALE; MITOCHONDRIA; OBESITY; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 84991109499     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4121-2     Document Type: Article

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