Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance

Biochemical and Biophysical Research Communications

Volumn 301, Issue 2, 2003, Pages 578-582

  Hammarstedt, A ^a   Jansson, P A ^a   Wesslau, C ^a   Yang, X ^a   Smith, U ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Diabetes; Gene expression; GLUT 4; Insulin resistance; IRS 1; PGC 1

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA CO ACTIVATOR 1; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ADIPOSE TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

EID: 0037423717     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00014-7     Document Type: Article

References (29)

1. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92:1998;829-839.
2. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98:1999;115-124.
3. Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., Newgard C.B., Spiegelman B.M. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413:2001;131-138.
4. Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., Lowell B.B., Bassel-Duby R., Spiegelman B.M. Transcriptional co-activator PGC-1. α drives the formation of slow-twitch muscle fibres Nature. 418:2002;797-801.
5. Michael L.F., Wu Z., Cheatham R.B., Puigserver P., Adelmant G., Lehman J.J., Kelly D.P., Spiegelman B.M. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc. Natl. Acad. Sci. USA. 98:2001;3820-3825.
6. Esterbauer H., Oberkofler H., Krempler F., Patsch W. Human peroxisome proliferator activated receptor. γ coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression Genomics. 62:1999;98-102.
7. Larrouy D., Vidal H., Andreelli F., Laville M., Langin D. Cloning and mRNA tissue distribution of human PPAR. γ coactivator-1 Int. J. Obes. Relat. Metab. Disord. 23:1999;1327-1332.
8. Goto M., Terada S., Kato M., Katoh M., Yokozeki T., Tabata I., Shimokawa T. cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem. Biophys. Res. Commun. 274:2000;350-354.
9. Puigserver P., Rhee J., Lin J., Wu Z., Yoon J.C., Zhang C.Y., Krauss S., Mootha V.K., Lowell B.B., Spiegelman B.M. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPAR. γ coactivator-1 Mol. Cell. 8:2001;971-982.
10. Pratley R.E., Thompson D.B., Prochazka M., Baier L., Mott D., Ravussin E., Sakul H., Ehm M.G., Burns D.K., Foroud T., Garvey W.T., Hanson R.L., Knowler W.C., Bennett P.H., Bogardus C. An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J. Clin. Invest. 101:1998;1757-1764.
11. Hara K., Tobe K., Okada T., Kadowaki H., Akanuma Y., Ito C., Kimura S., Kadowaki T. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia. 45:2002;740-743.
12. Ek J., Andersen G., Urhammer S.A., Hansen L., Carstensen B., Borch-Johnsen K., Drivsholm T., Berglund L., Hansen T., Lithell H., Pedersen O. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-. γ 2 (PPAR- γ 2) gene in relation to insulin sensitivity among glucose tolerant caucasians Diabetologia. 44:2001;1170-1176.
13. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 46:1997;3-10.
14. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:2001;941-946.
15. Abel E.D., Peroni O., Kim J.K., Kim Y.B., Boss O., Hadro E., Minnemann T., Shulman G.I., Kahn B.B. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 409:2001;729-733.
16. Zierath J.R., Krook A., Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia. 43:2000;821-835.
17. Carvalho E., Jansson P.A., Nagaev I., Wenthzel A.M., Smith U. Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J. 15:2001;1101-1103.
18. Rondinone C.M., Wang L.M., Lonnroth P., Wesslau C., Pierce J.H., Smith U. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 94:1997;4171-4175.
19. Carvalho E., Jansson P.A., Axelsen M., Eriksson J.W., Huang X., Groop L., Rondinone C., Sjostrom L., Smith U. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J. 13:1999;2173-2178.
20. Krotkiewski M., Bjorntorp P., Sjostrom L., Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J. Clin. Invest. 72:1983;1150-1162.
21. Attvall S., Eriksson B.M., Fowelin J., von Schenck H., Lager I., Smith U. Early posthypoglycemic insulin resistance in man is mainly an effect of. β -adrenergic stimulation J. Clin. Invest. 80:1987;437-442.
22. Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
23. Yang X., Pratley R.E., Tokraks S., Bogardus C., Permana P.A. Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians. Diabetologia. 45:2002;1584-1593.
24. DeFronzo R.A. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 37:1988;667-687.
25. Shulman G.I., Rothman D.L., Jue T., Stein P., DeFronzo R.A., Shulman R.G. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322:1990;223-228.
26. Rothman D.L., Magnusson I., Cline G., Gerard D., Kahn C.R., Shulman R.G., Shulman G.I. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 92:1995;983-987.
27. Smith U. Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance - is insulin resistance initiated in the adipose tissue? Int. J. Obes. Relat. Metab. Disord. 26:2002;897-904.
28. Krief S., Lonnqvist F., Raimbault S., Baude B., Van Spronsen A., Arner P., Strosberg A.D., Ricquier D., Emorine L.J. Tissue distribution of. β 3-adrenergic receptor mRNA in man J. Clin. Invest. 91:1993;344-349.
29. Cederberg A., Gronning L.M., Ahren B., Tasken K., Carlsson P., Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell. 106:2001;563-573.