A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

Molecular Cell

Volumn 63, Issue 2, 2016, Pages 229-239

  Jiang, Xian ^a   Li, Li ^b   Ying, Zhengxin ^a   Pan, Chenjie ^a   Huang, Shaoqiang ^a   Li, Lin ^a   Dai, Miaomiao ^a   Yan, Bo ^a   Li, Ming ^a   Jiang, Hui ^a   Chen, She ^a   Zhang, Zhiyuan ^a   Wang, Xiaodong ^a  

^a NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DIMETHOXYBENZYL) 5 [2 (METHYLSULFONYL) 6 (TRIFLUOROMETHYL)PYRIMIDIN 4 YL]PYRIDIN 2(1H); BIM PROTEIN; CASPASE 3; CASPASE 9; CYSTEINE; CYTOCHROME C; OXIDOREDUCTASE INHIBITOR; PROTEIN BAX; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE SUBUNIT B; UNCLASSIFIED DRUG; 1-(3,4-DIMETHOXYBENZYL)-5-(2-(METHYLSULFONYL)-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-YL)PYRIDIN-2(1H)-ONE; ANTIPARKINSON AGENT; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; BCL2L11 PROTEIN, HUMAN; NEUROPROTECTIVE AGENT; OXIDOPAMINE; PROTEIN BAK; PROTEIN BINDING; PYRIDONE DERIVATIVE; SDHB PROTEIN, HUMAN; SULFONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; ELECTRON TRANSFER CHAIN; ELECTRON TRANSPORT; ENZYME INACTIVATION; FEMALE; HUMAN; HUMAN CELL; IC50; MITOCHONDRION; MOLECULAR SIZE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STRUCTURE; RAT; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HELA CELL LINE; METABOLISM; MOTOR ACTIVITY; PARKINSONIAN DISORDERS; PATHOLOGY; PSYCHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; ANTIPARKINSON AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-2-LIKE PROTEIN 11; BEHAVIOR, ANIMAL; CELL PROLIFERATION; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; HELA CELLS; HUMANS; MITOCHONDRIA; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSONIAN DISORDERS; PROTEIN BINDING; PYRIDONES; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SUCCINATE DEHYDROGENASE; SULFONES; TIME FACTORS; TRANSFECTION;

EID: 84991058572     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.06.016     Document Type: Article

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