Rabs and GAPs in starvation-induced autophagy

Small GTPases

Volumn 7, Issue 4, 2016, Pages 265-269

  Lamb, Christopher A ^a   Longatti, Andrea ^a   Tooze, Sharon A ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

ATG9; autophagosome; autophagy; Rab proteins; TBC domains; TRAPPIII

Indexed keywords

AUTOPHAGY RELATED PROTEIN 9; COAT PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LIPID; MAMMALIAN TARGET OF RAPAMYCIN C1; MEMBRANE PROTEIN; PROTEIN; RAB PROTEIN; RAB11 PROTEIN; SNARE PROTEIN; TBC1D14 PROTEIN; TRANSPORT PROTEIN PARTICLE III; UNCLASSIFIED DRUG; AUTOPHAGY RELATED PROTEIN;

AUTOPHAGOSOME; AUTOPHAGY; CELL MEMBRANE; CYTOPLASM VESICLE; ENZYME ACTIVITY; HUMAN; MAMMAL CELL; NONHUMAN; NOTE; OMEGASOME; PHAGOPHORE; PROTEIN INTERACTION; RECEPTOR UPREGULATION; ANIMAL; ENDOSOME; METABOLISM;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEINS; ENDOSOMES; GTPASE-ACTIVATING PROTEINS; HUMANS; RAB GTP-BINDING PROTEINS;

EID: 84991039873     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.1080/21541248.2016.1220779     Document Type: Note

References (28)

1. Mizushima N, Yoshimori T, Ohsumi Y. The Role of Atg Proteins in Autophagosome Formation. Ann Rev Cell Dev Biol 2011; 27:107-32; PMID:21801009; http://dx.doi.org/10.1146/annurev-cellbio-092910-154005
2. Zaffagnini G, Martens S. Mechanisms of selective autophagy. J Mol Biol 2016; 428:1714-24; PMID:26876603; http://dx.doi.org/10.1016/j.jmb.2016.02.004
3. Lamb CA, Yoshimori T, Tooze SA. The autophagosome:origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 2013; 14:759-74; PMID:24201109; http://dx.doi.org/10.1038/nrm3696
4. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685-701; PMID:18725538; http://dx.doi.org/10.1083/jcb.200803137
5. Hosokawa N, Sasaki T, Iemura SI, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 2009; 5:973-9; PMID:19597335; http://dx.doi.org/10.4161/auto.5.7.9296
6. Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649-62; PMID:19287211; http://dx.doi.org/10.4161/auto.5.5.8249
7. Karanasios E, Stapleton E, Manifava M, Kaizuka T, Mizushima N, Walker SA, Ktistakis NT. Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci 2013; 126:5224-38; PMID:24013547; http://dx.doi.org/10.1242/jcs.132415
8. Koyama-Honda I, Itakura E, Fujiwara TK, Mizushima N. Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site. Autophagy 2013; 9:1491-9; PMID:23884233; http://dx.doi.org/10.4161/auto.25529
9. Orsi A, Razi M, Dooley H, Robinson D, Weston A, Collinson L, Tooze S. Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, is required for autophagy. Mol Biol Cell 2012; 23:1860-73; PMID:22456507; http://dx.doi.org/10.1091/mbc.E11-09-0746
10. Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19:5360-72; PMID:18843052; http://dx.doi.org/10.1091/mbc.E08-01-0080
11. Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 2008; 105(49):19211-6
12. Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell 2014; 55:238-52; PMID:24954904; http://dx.doi.org/10.1016/j.molcel.2014.05.021
13. Shpilka T, Weidberg H, Pietrokovski S, Elazar Z. Atg8:an autophagy-related ubiquitin-like protein family. Genome Biol 2011; 12:226; PMID:21867568; http://dx.doi.org/10.1186/gb-2011-12-7-226
14. Ge L, Melville D, Zhang M, Schekman R. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife 2013; 2:e00947; PMID:23930225; http://dx.doi.org/10.7554/eLife.00947
15. Ao X, Zou L, Wu Y. Regulation of autophagy by the Rab GTPase network. Cell Death Differ 2014; 21:348-58; PMID:24440914; http://dx.doi.org/10.1038/cdd.2013.187
16. Kern A, Dikic I, Behl C. The integration of autophagy and cellular trafficking pathways via RAB GAPs. Autophagy 2015; 11:2393-7; PMID:26565612; http://dx.doi.org/10.1080/15548627.2015.1110668
17. Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M. Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation. Mol Biol Cell 2008; 19:2916-25; PMID:18448665; http://dx.doi.org/10.1091/mbc.E07-12-1231
18. Itoh T, Kanno E, Uemura T, Waguri S, Fukuda M. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol 2011; 192:839-53; PMID:21383079; http://dx.doi.org/10.1083/jcb.201008107
19. Seaman MN, Harbour ME, Tattersall D, Read E, Bright N. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci 2009; 122:2371-82; PMID:19531583; http://dx.doi.org/10.1242/jcs.048686
20. Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy:regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol 2012; 32:1733-44; PMID:22354992; http://dx.doi.org/10.1128/MCB.06717-11
21. Longatti A, Lamb CA, Razi M, Yoshimura S-I, Barr FA, Tooze SA. TBC1D14 regulates autophagosome formation via Rab11 and recycling endosomes. J Cell Biol 2012; 197:659-75; PMID:22613832; http://dx.doi.org/10.1083/jcb.201111079
22. Popovic D, Dikic I. TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep 2014; 15:392-401; PMID:24603492; http://dx.doi.org/10.1002/embr.201337995
23. Lamb CA, Nuhlen S, Judith D, Frith D, Snijders AP, Behrends C, Tooze SA. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J 2016; 35:281-301; PMID:26711178; http://dx.doi.org/10.15252/embj.201592695
24. Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y. Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site. J Biol Chem 2012; 287(53):44261-9
25. Lynch-Day MA, Bhandari D, Menon S, Huang J, Cai H, Bartholomew CR, Brumell JH, Ferro-Novick S, Klionsky DJ. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A 2010; 107:7811-6; PMID:20375281; http://dx.doi.org/10.1073/pnas.1000063107
26. Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y. Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol 2012; 198:219-33; PMID:22826123; http://dx.doi.org/10.1083/jcb.201202061
27. Rink J, Ghigo E, Kalaidzidis Y, Zerial M. Rab conversion as a mechanism of progression from early to late endosomes. Cell 2005; 122:735-49; PMID:16143105; http://dx.doi.org/10.1016/j.cell.2005.06.043
28. Hutagalung AH, Novick PJ. Role of Rab GTPases in Membrane Traffic and Cell Physiology. Physiological reviews 2011; 91:119-49; PMID:21248164; http://dx.doi.org/10.1152/physrev.00059.2009