The structure of the antibiotic deactivating, N-hydroxylating rifampicin monooxygenase

Journal of Biological Chemistry

Volumn 291, Issue 41, 2016, Pages 21553-21562

  Liu, Li Kai ^a   Abdelwahab, Heba ^c,d   Martin Del Campo, Julia S ^c   Mehra Chaudhary, Ritcha ^b   Sobrado, Pablo ^c   Tanner, John J ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^d Damietta University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BINS; DISSOCIATION; KETONES;

ANTI-MICROBIAL ACTIVITY; BIOSYNTHETIC PATHWAY; CONFORMATIONAL CHANGE; DISSOCIATION CONSTANT; OXYTETRACYCLINES (OTC); QUATERNARY STRUCTURE; RESOLUTION STRUCTURE; SPECTROPHOTOMETRIC CHARACTERIZATION;

X RAY SCATTERING;

FLAVINE ADENINE NUCLEOTIDE; HOMODIMER; NAPHTHOQUINONE; OLIGOMER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIFAMPICIN; RIFAMPICIN MONOOXYGENASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; BACTERIAL PROTEIN; FLAVOPROTEIN; MIXED FUNCTION OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; DISSOCIATION CONSTANT; ENZYME SUBSTRATE COMPLEX; NOCARDIA FARCINICA; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYMOLOGY; GENETICS; HYDROXYLATION; METABOLISM; NOCARDIA; PROTEIN MULTIMERIZATION;

BACTERIAL PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; FLAVOPROTEINS; HYDROXYLATION; MIXED FUNCTION OXYGENASES; NADP; NOCARDIA; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RIFAMPIN;

EID: 84990973239     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.745315     Document Type: Article

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