Familial risk and childhood adversity interplay in the onset of psychosis

BJPsych Open

Volumn 1, Issue 1, 2015, Pages 6-13

  Trotta, Antonella ^a   Di Forti, Marta ^a   Iyegbe, Conrad ^a   Green, Priscilla ^a   Dazzan, Paola ^a   Mondelli, Valeria ^a   Morgan, Craig ^a   Murray, Robin M ^a   Fisher, Helen L ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84990933670     PISSN: None     EISSN: 20564724     Source Type: Journal    
DOI: 10.1192/bjpo.bp.115.000158     Document Type: Article

References (53)

1. Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A. Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. Am J Psychiatry 2011; 168: 65-72.
2. Kelleher I, Harley M, Lynch F, Arseneault L, Fitzpatrick C, Cannon M. Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. Br J Psychiatry 2008; 193: 378-82.
3. Wolke D, Lereya ST, Fisher HL, Lewis G, Zammit S. Bullying in elementary school and psychotic experiences at 18 years: a longitudinal, population-based cohort study. Psychol Med 2014; 44: 2199-211.
4. Bechdolf A, Thompson A, Nelson B, Cotton S, Simmons MB, Amminger GP, et al. Experience of trauma and conversion to psychosis in an ultra-high-risk (prodro-mal) group. Acta Psychiatr Scand 2010; 121: 377-84.
5. Fisher H, Jones P, Fearon P, Craig TK, Dazzan P, Morgan K, et al. The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychol Med 2010; 40: 1976-8.
6. Bebbington P, Jonas S, Kuipers E, King M, Cooper C, Brugha T, et al. Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey in England. Br J Psychiatry 2011; 199: 29-37.
7. Trotta A, Di Forti M, Mondelli V, Dazzan P, Pariante C, David A, et al. Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls. Schizophr Res 2013; 150: 169-75.
8. van Winkel R, Stefanis NC, Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull 2008; 34: 1095-105.
9. Sullivan PF. The genetics of schizophrenia. PLoS Med 2005; 2: e212.
10. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009; 373: 234-9.
11. Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 2000; 97: 12-7.
12. Walsh C, MacMillan H, Jamieson E. The relationship between parental psychiatric disorder and child physical and sexual abuse: findings from the Ontario Health Supplement. Child Abuse Negl 2002; 26: 11-22.
13. Walder DJ, Faraone SV, Glatt SJ, Tsuang MT, Seidman LJ. Genetic liability, prenatal health, stress and family environment: risk factors in the Harvard Adolescent Family High Risk for Schizophrenia Study. Schizophr Res 2014; 157: 142-8.
14. Asarnow RF, Nuechterlein KH, Fogelson D, Subotnik KL, Payne DA, Russell AT, et al. Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia: the UCLA family study. Arch Gen Psychiatry 2001; 58: 581-8.
15. Polanczyk G, Moffitt TE, Arseneault L, Cannon M, Ambler A, Keefe RS, et al. Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry 2010; 67: 328-38.
16. Plomin R, DeFries JC, Loehlin JC. Genotype-environment interaction and correlation in the analysis of human behaviour. Psychol Bull 1977; 84: 309-22.
17. van Os J, Rutten BPF, Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 2008; 34: 1066-82.
18. Carter JW, Schulsinger F, Parnas J, Cannon T, Mednick SA. A multivariate prediction model of schizophrenia. Schizophr Bull 2002; 28: 649-82.
19. van Os J, Sham P. Gene-environment interactions. In The Epidemiology of Schizophrenia (eds RM Murray, PB Jones, E Susser, J Van Os, M Cannon): 235-54. Cambridge University Press, 2003.
20. Tienari P, Wynne LC, Läksy K, Moring J, Nieminen P, Sorri A, et al. Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish Adoptive Family Study of Schizophrenia. Am J Psychiatry 2003; 160: 1587-94.
21. McGrath JJ, Mortensen PB, Visscher PM, Wray NR. Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. Schizophr Bull 2013; 39: 955-9.
22. Jaffee SR, Price TS. The implications of genotype-environment correlation for establishing causal processes in psychopathology. Dev Psychopathol 2012; 24: 1253-64.
23. Alemany S, Goldberg X, van Winkel R, Gastó C, Peralta V, Fañanás L. Childhood adversity and psychosis: examining whether the association is due to genetic confounding using a monozygotic twin differences approach. Eur Psychiatry 2013; 28: 207-12.
24. Heins M, Simons C, Lataster T, Pfeifer S, Versmissen D, Lardinois M, et al. Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma. Am J Psychiatry 2011; 168: 1286-94.
25. Pfeifer S, Krabbendam L, Myin-Germeys I, Derom C, Wichers M, Jacobs N, et al. A cognitive intermediate phenotype study confirming possible gene-early adversity interaction in psychosis outcome: a general population twin study. Psychosis 2010; 2: 1-11.
26. Wigman JT, van Winkel R, Ormel J, Verhulst FC, van Os J, Vollebergh WA. Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta Psychiatr Scand 2012; 126: 266-73.
27. Fisher HL, McGuffin P, Boydell J, Fearon P, Craig TK, Dazzan P, et al. Interplay between childhood physical abuse and familial risk in the onset of psychotic disorders. Schizophr Bull 2014; 40: 1443-51.
28. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Description and Diagnostic Guidelines. World Health Organization, 1992.
29. World Health Organization. Schedules for Clinical Assessment in Neuropsychiatry (SCAN). World Health Organization, 1994.
30. Bebbington P, Nayani T. The psychosis screening questionnaire. J Methods Psychiatr Res 1995; 5: 11-20.
31. Mallett R. Sociodemographic Schedule. Section of Social Psychiatry, Institute of Psychiatry, 1997.
32. Bifulco A, Bernazzani O, Moran PM, Jacobs C. The Childhood Experiences of Care and Abuse Questionnaire (CECA.Q) - validation in a community series. Br J Clin Psychol 2005; 44: 563-81.
33. Smith N, Lam D, Bifulco A, Checkley S. Childhood Experience of Care and Abuse Questionnaire (CECA.Q): validation of a screening instrument for childhood adversity in clinical populations. Soc Psychiatry Psychiatr Epidemiol 2002; 37: 572-9.
34. Fisher HL, Craig TK, Fearon P, Morgan K, Dazzan P, Lappin J, et al. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull 2011; 37: 546-53.
35. Knol MJ, van der Tweel I, Grobbee DE, Numans ME, Geerlings MI. Estimating interaction on an additive scale between continuous determinants in a logistic regression model. Int J Epidemiol 2007; 36: 1111-8.
36. Schwartz S, Susser E. Relationships among causes. In Psychiatric Epidemiology: Searching for the Causes of Mental Disorders (eds E Susser, S Schwartz, A Morabia, EJ Bromet): 62-74. Oxford University Press, 2006.
37. Morgan C, Reininghaus U, Fearon P, Hutchinson G, Morgan K, Dazzan P, et al. Modelling the interplay between childhood and adult adversity in pathways to psychosis: initial evidence from the AESOP study. Psychol Med 2014; 44: 407-19.
38. Morgan C, Reininghaus U, Reichenberg A, Frissa S; SELCoH study team, Hotopf M, et al. Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects. Br J Psychiatry 2014; 204: 346-53.
39. Wechsler D. Wechsler Adult Intelligence Scale-Third Edition. The Psychological Corporation, 1997.
40. Morgan C, Kirkbride J, Leff J, Craig T, Hutchinson G, McKenzie K, et al. Parental separation, loss and psychosis in different ethnic groups: a case-control study. Psychol Med 2007; 37: 495-503.
41. Radford L, Corral S, Bradley C, Collishaw S, Fisher HL. The prevalence and impact of child maltreatment and victimisation in the UK: findings from a population survey of children and young people aged 0 to 17 years. Child Abuse Negl 2013; 37: 801-13.
42. Della Femina D, Yeager CA, Lewis DC. Child abuse: adolescent records versus adult recall. Child Abuse Negl 1990; 14: 227-31.
43. Hardt J, Rutter M. Validity of adult retrospective reports of adverse childhood experiences: review of the evidence. J Child Psychol Psychiatry 2004; 45: 260-73.
44. Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 2012; 38: 661-71.
45. Bifulco A, Brown GW, Harris TO. Childhood Experience of Care and Abuse (CECA): a retrospective interview measure. J Child Psychol Psychiatry 1994; 35: 1419-35.
46. Di Forti M, Morgan C, Dazzan P, Pariante C, Mondelli V, Reis Marques T, et al. High-potency cannabis and the risk of psychosis. Br J Psychiatry 2009; 195: 488-91.
47. Beards S, Gayer-Anderson C, Borges S, Dewey ME, Fisher HL, Morgan C. Life events and psychosis: a review and meta-analysis. Schizophr Bull 2013; 39: 740-7.
48. Farmer A, McGuffin P, Gottesman II. Problems and pitfalls of the family history positive and negative dichotomy: response to Dalén. Schizophr Bull 1990; 16: 367-70.
49. Iyegbe C, Campbell D, Butler A, Ajnakina O, Sham P. The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research. Soc Psychiatry Psychiatr Epidemiol 2014; 49: 169-82.
50. Agerbo E, Mortensen PB, Wiuf C, Pedersen MS, McGrath J, Hollegaard MV. Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia: a Danish national birth cohort-based study. Schizophr Res 2012; 134: 246-52.
51. Kelleher I, Keeley H, Corcoran P, Ramsay H, Wasserman C, Carli V, et al. Childhood trauma and psychosis in a prospective cohort study: cause, effect and directionality. Am J Psychiatry 2013; 170: 734-41.
52. Mathews S, Onwumere J, Bissoli S, Ruggeri M, Kuipers E, Valmaggia L. Measuring attachment and parental bonding in psychosis and its clinical implications. Epidemiol Psychiatr Sci 2014; 19: 1-8.
53. Gayer-Anderson C, Morgan C. Social networks, support and early psychosis: a systematic review. Epidemiol Psychiatr Sci 2013; 22: 131-46.