Mogrol derived from Siraitia grosvenorii mogrosides suppresses 3T3-L1 adipocyte differentiation by reducing cAMP-response element-binding protein phosphorylation and increasing AMP-activated protein kinase phosphorylation

PLoS ONE

Volumn 11, Issue 9, 2016, Pages

  Harada, Naoki ^a   Ishihara, Mikako ^a   Horiuchi, Hiroko ^a   Ito, Yuta ^a,b   Tabata, Hiromitsu ^b   Suzuki, Yasushi A ^b   Nakano, Yoshihisa ^a   Yamaji, Ryoichi ^a   Inui, Hiroshi ^a  

^a Osaka Prefecture University   (Japan)

^b SARAYA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; AGLYCONE; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MOGROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; TRITERPENE;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; LIPID STORAGE; MEDICINAL PLANT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIRAITIA GROSVENORII; 3T3-L1 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CUCURBITACEAE; CYTOLOGY; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; MOUSE; PHOSPHORYLATION;

3T3-L1 CELLS; ADIPOCYTES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL DIFFERENTIATION; CUCURBITACEAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; LIPID METABOLISM; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84990903080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0162252     Document Type: Article

References (44)

1. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-887. doi: 10.1038/nature05488 PMID: 17167477.
2. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643. doi: 10.1038/35007508 PMID: 10766250.
3. Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-Analysis. JAMA 2013; 309: 71-82. doi: 10.1001/jama.2012.113905 PMID: 23280227.
4. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Ann. Rev. Cell Dev. Biol. 2000; 16: 145-171. doi: 10.1146/annurev.cellbio.16.1.145 PMID: 11031233.
5. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol. Rev. 1998; 78: 783-809. PMID: 9674695.
6. Darlington GJ, Ross SE, MacDougald OA. The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem. 1998; 273: 30057-30060. doi: 10.1074/jbc.273.46.30057 PMID: 9804754.
7. Li SF, Guo L, Qian SW, Liu Y, Zhang YY, Zhang ZC, et al. G9a is transactivated by C/EBPbeta to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation. Am. J. Physiol. Endocrinol. Metab. 2013; 304: E990-998. doi: 10.1152/ajpendo.00608.2012 PMID: 23512806.
8. Reusch JE, Colton LA, Klemm DJ. CREB activation induces adipogenesis in 3T3-L1 cells. Mol. Cell. Biol. 2000; 20: 1008-10020. doi: 10.1128/MCB.20.3.1008-1020.2000 PMID: 10629058.
9. Kuri-Harcuch W, Wise LS, Green H. Interruption of the adipose conversion of 3T3 cells by biotin deficiency: Differentiation without triglyceride accumulation. Cell. 1978; 14: 53-59. doi: 10.1016/0092- 8674(78)90300-8 PMID: 667936.
10. Daval M, Foufelle F, Ferre P. Functions of AMP-Activated protein kinase in adipose tissue. J. Physiol. 2006; 574: 55-62. doi: 10.1113/jphysiol.2006.111484 PMID: 16709632.
11. Yin W, Mu J, Birnbaum MJ. Role of AMP-Activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. J. Biol. Chem. 2003; 278: 43074-43080. doi: 10.1074/jbc.M308484200 PMID: 12941946.
12. Habinowski SA, Witters LA. The effects of AICAR on adipocyte differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 2001; 286: 852-856. doi: 10.1006/bbrc.2001.5484 PMID: 11527376.
13. Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, et al. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr. Metab. 2006; 3: 31. DOI: 10.1186/1743-7075-3-31 PMID: 16901342.
14. Lee H, Kang R, Bae S, Yoon Y. AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/betacatenin pathway in 3T3-L1 adipocytes. Int. J. Mol. Med. 2011; 28: 65-71. doi: 10.3892/ijmm.2011.674 PMID: 21491080.
15. Daval M, Diot-Dupuy F, Bazin R, Hainault I, Viollet B, Vaulont S, et al. Anti-lipolytic action of AMP-Activated protein kinase in rodent adipocytes. J. Biol. Chem. 2005; 280: 25250-25257. doi: 10.1074/jbc. M414222200 PMID: 15878856.
16. Kasai R, Nie R-L, Nashi K, Ohtani K, Zhou J, Tao G-D, et al. Sweet cucurbitane glycosides from fruits of Siraitia siamensis (chi-zi luo-han-guo), a Chinese folk medicine. Agric. Biol. Chem. 1989; 53: 3347-3349. doi: 10.1080/00021369.1989.10869815
17. Murata Y, Ogawa T, Suzuki YA, Yoshikawa S, Inui H, Sugiura M, et al. Digestion and absorption of Siraitia grosvenori triterpenoids in the rat. Biosci. Biotechnol. Biochem. 2010; 74: 673-676. doi: 10.1271/bbb.90832 PMID: 20208371.
18. Matsumoto K, Kasai R, Ohtani K, Tanaka O. Minor Cucurbitane-Glycosides from Fruits of Siraitia grosvenori (Cucurbitaceae). Chem. Pharm. Bull. 1990; 38: 2030-2032. doi: 10.1248/cpb.38.2030
19. Rayalam S, Della-Fera MA, Baile CA. Phytochemicals and regulation of the adipocyte life cycle. J. Nutr. Biochem. 2008; 19: 717-726. doi: 10.1016/j.jnutbio.2007.12.007 PMID: 18495457.
20. Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, Hashimoto T, Kanazawa K, et al. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci. Biotechnol. Biochem. 2004; 68: 2353-2359. doi: 10.1271/bbb.68.2353 PMID: 15564676.
21. Hsu CL, Yen GC. Induction of cell apoptosis in 3T3-L1 pre-Adipocytes by flavonoids is associated with their antioxidant activity. Mol. Nutr. Food Res. 2006; 50: 1072-1079. doi: 10.1002/mnfr.200600040 PMID: 17039455.
22. Kawada T, Kamei Y, Fujita A, Hida Y, Takahashi N, Sugimoto E, et al. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. BioFactors 2000; 13: 103-1099. DOI: 10. 1002/biof.5520130117 PMID: 11237167.
23. Suzuki YA, Tomoda M, Murata Y, Inui H, Sugiura M, Nakano Y. Antidiabetic effect of long-term supplementation with Siraitia grosvenori on the spontaneously diabetic Goto-Kakizaki rat. Br. J. Nutr. 2007; 97: 770-775. doi: 10.1017/s0007114507381300 PMID: 17349091.
24. Suzuki YA, Murata Y, Inui H, Sugiura M, Nakano Y. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. J. Agric. Food Chem. 2005; 53: 2941-2946. doi: 10.1021/jf0478105 PMID: 15826043.
25. Chen XB, Zhuang JJ, Liu JH, Lei M, Ma L, Chen J, et al. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle. Bioorg. Med. Chem. 2011; 19: 5776-5781. doi: 10.1016/j. bmc.2011.08.030 PMID: 21893415.
26. Xu F, Li DP, Huang ZC, Lu FL, Wang L, Huang YL, et al. Exploring in vitro, in vivo metabolism of mogroside V and distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MS(n). J. Pharm. Biomed. Anal. 2015; 115: 418-430. doi: 10.1016/j.jpba.2015.07.024 PMID: 26280925.
27. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991; 5: 1538-1552. PMID: 1840554.
28. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957; 226: 497-509. PMID: 13428781.
29. Wise LS, Green H. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J. Biol. Chem. 1979; 254: 273-275. PMID: 762059.
30. Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R. S-Equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic betacells. J. Nutr. Sci. Vitaminol. 2014; 60: 291-296. doi: 10.3177/jnsv.60.291 PMID: 25297619.
31. Harada N, Yasunaga R, Higashimura Y, Yamaji R, Fujimoto K, Moss J, et al. Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells. J. Biol. Chem. 2007; 282: 22651-22661. doi: 10.1074/jbc.M610724200 PMID: 17553795.
32. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 1995; 9: 168-181. DOI: 10. 1101/gad.9.2.168 PMID: 7531665.
33. Tong L. Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery. Cell. Mol. Life Sci. 2005; 62: 1784-803. doi: 10.1007/s00018-005-5121-5124 PMID: 15968460.
34. Leff T. AMP-Activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins. Biochem. Soc. Trans. 2003; 31: 224-227. doi: 10.1042/PMID: 12546690.
35. Yang W, Hong YH, Shen XQ, Frankowski C, Camp HS, Leff T. Regulation of transcription by AMP-Activated protein kinase: Phosphorylation of p300 blocks its interaction with nuclear receptors. J. Biol. Chem. 2001; 276: 38341-38344. doi: 10.1074/jbc.C100316200 PMID: 11518699.
36. Zhang JW, Tang QQ, Vinson C, Lane MD. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. U.S.A. 2004; 101: 43-47. DOI: 10. 1073/pnas.0307229101 PMID: 14688407.
37. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-Activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006; 55: 2256-2264. doi: 10.2337/db06-0006 PMID: 16873688.
38. Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-Activated protein kinase. Biochem. Biophys. Res. Commun. 2005; 338: 694-699. doi: 10.1016/j.bbrc.2005.09.195 PMID: 16236247.
39. Ono M, Fujimori K. Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells. J. Agric. Food Chem. 2011; 59: 13346-13352. doi: 10.1021/jf203490a PMID: 22098587.
40. Choi Y, Kim Y, Ham H, Park Y, Jeong HS, Lee J. Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-Activated protein kinase (AMPK). J. Aagric. Food Chem. 2011; 59: 12843-12849. doi: 10.1021/jf2033208 PMID: 22088202.
41. Chen S, Li Z, Li W, Shan Z, Zhu W. Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Can. J. Physiol. Pharmacol. 2011; 89: 793-799. doi: 10.1139/y11-077 PMID: 22017765.
42. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 2008; 373: 545-549. doi: 10.1016/j. bbrc.2008.06.077 PMID: 18586010.
43. Zhang J, Tang H, Deng R, Wang N, Zhang Y, Wang Y, et al. Berberine Suppresses Adipocyte Differentiation via Decreasing CREB Transcriptional Activity. PLoS One 2015; 10: E0125667. doi: 10.1371/journal.pone.0125667 PMID: 25928058.
44. Harmon AW, Patel YM, Harp JB. Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression. Biochem. J. 2002; 367: 203-208. doi: 10.1042/bj20020300 PMID: 12095417.